The effects of vitamin B12 on the TLR-4/NF-κB signaling pathway in ovarian ischemia-reperfusion injury-related inflammation

[Display omitted] •Vitamin B12 reduced ovarian damage caused by ischemia/reperfusion.•Vitamin B12 decreased oxidative stress/inflammation damage by TLR-4/NF-κB pathway.•Vitamin B12 has potential for the prevention of ovary torsion/detorsion injury. Ovarian ischemia is a gynecological emergency case...

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Veröffentlicht in:	International immunopharmacology 2022-06, Vol.107, p.108676-108676, Article 108676
Hauptverfasser:	Deniz, Esra, Topcu, Atilla, Ozturk, Aykut, Ozturk, Seda Duman, Arpa, Medeni, Atak, Mehtap
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Congestion Cyanocobalamin Cytokines Edema Follicles Glutathione Hemorrhage IL-1β Inflammation Injury prevention Interleukin 6 Ischemia Ischemia-Reperfusion NF-κB protein Ovaries Ovary Oxidative stress Rat Reperfusion Signal transduction Signaling Tissues TLR4 protein Toll-like receptors Vitamin B12
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