Inhibitory Effects of Euscaphic Acid in the Atopic Dermatitis Model by Reducing Skin Inflammation and Intense Pruritus
Atopic dermatitis (AD) is a complex and multifactorial skin disease characterized by skin inflammation and intense pruritus. There are many commercially available treatments such as topical corticosteroids and immunosuppressants to treat of AD, but their effectiveness is limited, and frequent use of...
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Veröffentlicht in: | Inflammation 2022-08, Vol.45 (4), p.1680-1691 |
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description | Atopic dermatitis (AD) is a complex and multifactorial skin disease characterized by skin inflammation and intense pruritus. There are many commercially available treatments such as topical corticosteroids and immunosuppressants to treat of AD, but their effectiveness is limited, and frequent use of these treatments can cause serious side effects. Therefore, the development of new therapeutic agents is necessary for the treatment of AD. Hence, an alternative agent that was derived from natural products that are effective and safe for AD treatment was investigated using experimental models. The biological activity of euscaphic acid has anti-inflammatory, anticoagulant, and antioxidant effects. Despite the various biomedical properties of euscaphic acid, its therapeutic effects on AD have not been well studied. In this study, we investigated the effects of euscaphic acid on skin inflammation and pruritus in AD mouse model. The effects of euscaphic acid were investigated in activated human epidermal keratinocytes and leukemia T lymphoblast cell lines, and
Dermatophagoides farina
extract and 2,4-dinitrochlorobenzene-induced AD mouse model. Euscaphic acid ameliorated AD properties, such as the expression of inflammatory cytokines and activation of transcription factors. In addition, euscaphic acid reduced critical factors for pruritus such as immunoglobulin E hyperproduction, mast cell invasion, and interleukin-33 expression. Taken together, euscaphic acid could be a potent therapeutic agent for the treatment of AD. |
doi_str_mv | 10.1007/s10753-022-01652-x |
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Dermatophagoides farina
extract and 2,4-dinitrochlorobenzene-induced AD mouse model. Euscaphic acid ameliorated AD properties, such as the expression of inflammatory cytokines and activation of transcription factors. In addition, euscaphic acid reduced critical factors for pruritus such as immunoglobulin E hyperproduction, mast cell invasion, and interleukin-33 expression. Taken together, euscaphic acid could be a potent therapeutic agent for the treatment of AD.</description><identifier>ISSN: 0360-3997</identifier><identifier>EISSN: 1573-2576</identifier><identifier>DOI: 10.1007/s10753-022-01652-x</identifier><identifier>PMID: 35257273</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acids ; Animal models ; Animals ; Antioxidants ; Atopic dermatitis ; Biological activity ; Biomedical and Life Sciences ; Biomedicine ; Corticosteroids ; Cytokines - metabolism ; Dermatitis ; Dermatitis, Atopic - chemically induced ; Dinitrochlorobenzene - pharmacology ; Disease Models, Animal ; Eczema ; Immunoglobulin E ; Immunology ; Immunosuppressive agents ; Inflammation ; Inflammation - drug therapy ; Inflammation - metabolism ; Internal Medicine ; Keratinocytes ; Mice ; Mice, Inbred BALB C ; Natural products ; Original Article ; Pathology ; Pharmacology/Toxicology ; Pruritus ; Pruritus - drug therapy ; Pruritus - metabolism ; Rheumatology ; Skin ; Skin diseases ; Transcription activation ; Transcription factors ; Triterpenes ; Tumor cell lines</subject><ispartof>Inflammation, 2022-08, Vol.45 (4), p.1680-1691</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-3b00ffb28f03e7403fae56eef8bfd38d3b1f6b4ff219b6d8e518e7c52acbef8f3</citedby><cites>FETCH-LOGICAL-c375t-3b00ffb28f03e7403fae56eef8bfd38d3b1f6b4ff219b6d8e518e7c52acbef8f3</cites><orcidid>0000-0002-6160-7354</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10753-022-01652-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10753-022-01652-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35257273$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeong, Na-Hee</creatorcontrib><creatorcontrib>Lee, Soyoung</creatorcontrib><creatorcontrib>Choi, Young-Ae</creatorcontrib><creatorcontrib>Song, Kyung-Sik</creatorcontrib><creatorcontrib>Kim, Sang-Hyun</creatorcontrib><title>Inhibitory Effects of Euscaphic Acid in the Atopic Dermatitis Model by Reducing Skin Inflammation and Intense Pruritus</title><title>Inflammation</title><addtitle>Inflammation</addtitle><addtitle>Inflammation</addtitle><description>Atopic dermatitis (AD) is a complex and multifactorial skin disease characterized by skin inflammation and intense pruritus. There are many commercially available treatments such as topical corticosteroids and immunosuppressants to treat of AD, but their effectiveness is limited, and frequent use of these treatments can cause serious side effects. Therefore, the development of new therapeutic agents is necessary for the treatment of AD. Hence, an alternative agent that was derived from natural products that are effective and safe for AD treatment was investigated using experimental models. The biological activity of euscaphic acid has anti-inflammatory, anticoagulant, and antioxidant effects. Despite the various biomedical properties of euscaphic acid, its therapeutic effects on AD have not been well studied. In this study, we investigated the effects of euscaphic acid on skin inflammation and pruritus in AD mouse model. The effects of euscaphic acid were investigated in activated human epidermal keratinocytes and leukemia T lymphoblast cell lines, and
Dermatophagoides farina
extract and 2,4-dinitrochlorobenzene-induced AD mouse model. Euscaphic acid ameliorated AD properties, such as the expression of inflammatory cytokines and activation of transcription factors. In addition, euscaphic acid reduced critical factors for pruritus such as immunoglobulin E hyperproduction, mast cell invasion, and interleukin-33 expression. Taken together, euscaphic acid could be a potent therapeutic agent for the treatment of AD.</description><subject>Acids</subject><subject>Animal models</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Atopic dermatitis</subject><subject>Biological activity</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Corticosteroids</subject><subject>Cytokines - metabolism</subject><subject>Dermatitis</subject><subject>Dermatitis, Atopic - chemically induced</subject><subject>Dinitrochlorobenzene - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Eczema</subject><subject>Immunoglobulin E</subject><subject>Immunology</subject><subject>Immunosuppressive agents</subject><subject>Inflammation</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - metabolism</subject><subject>Internal Medicine</subject><subject>Keratinocytes</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Natural products</subject><subject>Original Article</subject><subject>Pathology</subject><subject>Pharmacology/Toxicology</subject><subject>Pruritus</subject><subject>Pruritus - drug therapy</subject><subject>Pruritus - metabolism</subject><subject>Rheumatology</subject><subject>Skin</subject><subject>Skin diseases</subject><subject>Transcription activation</subject><subject>Transcription factors</subject><subject>Triterpenes</subject><subject>Tumor cell lines</subject><issn>0360-3997</issn><issn>1573-2576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp90U2PFCEQBmBiNO64-gc8GBIvXlqBGpru42QddZI1Gj_OpKGLHdZuGIE2O_9e1lk18eCJpHiqqPAS8pSzl5wx9SpzpiQ0TIiG8VaK5uYeWXGpoBFStffJikHLGuh7dUYe5XzNGOv6Dh6SM5BVCAUr8mMX9t74EtORbp1DWzKNjm6XbIfD3lu6sX6kPtCyR7op8VBLrzHNQ_HFZ_o-jjhRc6SfcFysD1f087eKd8FNw3yLYqBDGGuhYMhIP6Yl-bLkx-SBG6aMT-7Oc_L1zfbLxbvm8sPb3cXmsrGgZGnAMOacEZ1jgGrNwA0oW0TXGTdCN4LhrjVr5wTvTTt2KHmHykoxWFORg3Py4jT3kOL3BXPRs88Wp2kIGJesRQsKuBQCKn3-D72OSwp1u6pUu65f3K-rEidlU8w5odOH5OchHTVn-jYVfUpF11T0r1T0TW16djd6MTOOf1p-x1ABnECuV-EK09-3_zP2J3pcmdk</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Jeong, Na-Hee</creator><creator>Lee, Soyoung</creator><creator>Choi, Young-Ae</creator><creator>Song, Kyung-Sik</creator><creator>Kim, Sang-Hyun</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6160-7354</orcidid></search><sort><creationdate>20220801</creationdate><title>Inhibitory Effects of Euscaphic Acid in the Atopic Dermatitis Model by Reducing Skin Inflammation and Intense Pruritus</title><author>Jeong, Na-Hee ; Lee, Soyoung ; Choi, Young-Ae ; Song, Kyung-Sik ; Kim, Sang-Hyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-3b00ffb28f03e7403fae56eef8bfd38d3b1f6b4ff219b6d8e518e7c52acbef8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acids</topic><topic>Animal models</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Atopic dermatitis</topic><topic>Biological activity</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Corticosteroids</topic><topic>Cytokines - metabolism</topic><topic>Dermatitis</topic><topic>Dermatitis, Atopic - chemically induced</topic><topic>Dinitrochlorobenzene - pharmacology</topic><topic>Disease Models, Animal</topic><topic>Eczema</topic><topic>Immunoglobulin E</topic><topic>Immunology</topic><topic>Immunosuppressive agents</topic><topic>Inflammation</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - metabolism</topic><topic>Internal Medicine</topic><topic>Keratinocytes</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Natural products</topic><topic>Original Article</topic><topic>Pathology</topic><topic>Pharmacology/Toxicology</topic><topic>Pruritus</topic><topic>Pruritus - drug therapy</topic><topic>Pruritus - metabolism</topic><topic>Rheumatology</topic><topic>Skin</topic><topic>Skin diseases</topic><topic>Transcription activation</topic><topic>Transcription factors</topic><topic>Triterpenes</topic><topic>Tumor cell lines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeong, Na-Hee</creatorcontrib><creatorcontrib>Lee, Soyoung</creatorcontrib><creatorcontrib>Choi, Young-Ae</creatorcontrib><creatorcontrib>Song, Kyung-Sik</creatorcontrib><creatorcontrib>Kim, Sang-Hyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeong, Na-Hee</au><au>Lee, Soyoung</au><au>Choi, Young-Ae</au><au>Song, Kyung-Sik</au><au>Kim, Sang-Hyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitory Effects of Euscaphic Acid in the Atopic Dermatitis Model by Reducing Skin Inflammation and Intense Pruritus</atitle><jtitle>Inflammation</jtitle><stitle>Inflammation</stitle><addtitle>Inflammation</addtitle><date>2022-08-01</date><risdate>2022</risdate><volume>45</volume><issue>4</issue><spage>1680</spage><epage>1691</epage><pages>1680-1691</pages><issn>0360-3997</issn><eissn>1573-2576</eissn><abstract>Atopic dermatitis (AD) is a complex and multifactorial skin disease characterized by skin inflammation and intense pruritus. There are many commercially available treatments such as topical corticosteroids and immunosuppressants to treat of AD, but their effectiveness is limited, and frequent use of these treatments can cause serious side effects. Therefore, the development of new therapeutic agents is necessary for the treatment of AD. Hence, an alternative agent that was derived from natural products that are effective and safe for AD treatment was investigated using experimental models. The biological activity of euscaphic acid has anti-inflammatory, anticoagulant, and antioxidant effects. Despite the various biomedical properties of euscaphic acid, its therapeutic effects on AD have not been well studied. In this study, we investigated the effects of euscaphic acid on skin inflammation and pruritus in AD mouse model. The effects of euscaphic acid were investigated in activated human epidermal keratinocytes and leukemia T lymphoblast cell lines, and
Dermatophagoides farina
extract and 2,4-dinitrochlorobenzene-induced AD mouse model. Euscaphic acid ameliorated AD properties, such as the expression of inflammatory cytokines and activation of transcription factors. In addition, euscaphic acid reduced critical factors for pruritus such as immunoglobulin E hyperproduction, mast cell invasion, and interleukin-33 expression. Taken together, euscaphic acid could be a potent therapeutic agent for the treatment of AD.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35257273</pmid><doi>10.1007/s10753-022-01652-x</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-6160-7354</orcidid></addata></record> |
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subjects | Acids Animal models Animals Antioxidants Atopic dermatitis Biological activity Biomedical and Life Sciences Biomedicine Corticosteroids Cytokines - metabolism Dermatitis Dermatitis, Atopic - chemically induced Dinitrochlorobenzene - pharmacology Disease Models, Animal Eczema Immunoglobulin E Immunology Immunosuppressive agents Inflammation Inflammation - drug therapy Inflammation - metabolism Internal Medicine Keratinocytes Mice Mice, Inbred BALB C Natural products Original Article Pathology Pharmacology/Toxicology Pruritus Pruritus - drug therapy Pruritus - metabolism Rheumatology Skin Skin diseases Transcription activation Transcription factors Triterpenes Tumor cell lines |
title | Inhibitory Effects of Euscaphic Acid in the Atopic Dermatitis Model by Reducing Skin Inflammation and Intense Pruritus |
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