Aurora kinase blockade drives de novo addiction of cervical squamous cell carcinoma to druggable EGFR signalling

Oncogenic signalling confers tumour-progression advantages; thus, its pharmacological blockade is the best strategy for cancer chemotherapy. However, drug resistance and heterogeneous dependency of tumour hamper their therapeutic potential, suggesting the necessity for a new ubiquitous modality base...

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Veröffentlicht in:	Oncogene 2022-04, Vol.41 (16), p.2326-2339
Hauptverfasser:	Komatsu, Masayuki, Nakamura, Kanako, Takeda, Takashi, Chiwaki, Fumiko, Banno, Kouji, Aoki, Daisuke, Takeshita, Fumitaka, Sasaki, Hiroki
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 13/95 42/89 631/67/1059/602 631/67/1517/1371 631/80/313/1461 631/80/86/2368 64/60 96/1 Addictions Apoptosis Aurora kinase Cancer Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - genetics Cell Biology Cell Line, Tumor Cervical cancer Cervix Chemotherapy Drug resistance Drug Resistance, Neoplasm - genetics Epidermal growth factor receptors ErbB Receptors - metabolism Extracellular signal-regulated kinase Female Human Genetics Humans Internal Medicine Kinases Medicine Medicine & Public Health Oncogenes Oncology Organoids Signal Transduction Squamous cell carcinoma Tumors Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - genetics
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