Phenanthroindolizine alkaloids from Boehmeria sieboldiana leaves exhibit cytotoxicity against human cancer cell lines
To explore useful natural compounds from indigenous medicinal plants, the cytotoxic properties from a methanolic extract of Boehmeria sieboldiana leaves against human cancer cell lines were isolated in the present study. After purification of the extract, seco -dehydroantofine B ( 1 ) together with...
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| Veröffentlicht in: | Journal of natural medicines 2022-06, Vol.76 (3), p.670-674 |
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| container_title | Journal of natural medicines |
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| creator | Matsuo, Hirotaka Kawakami, Hitomi Anjiki, Naoko Kawano, Noriaki Fuchino, Hiroyuki Kawahara, Nobuo Yoshimatsu, Kayo |
| description | To explore useful natural compounds from indigenous medicinal plants, the cytotoxic properties from a methanolic extract of
Boehmeria sieboldiana
leaves against human cancer cell lines were isolated in the present study. After purification of the extract,
seco
-dehydroantofine B (
1
) together with two known phenanthroindolizine alkaloids,
seco
-dehydroantofine A (
2
) and septicine (
3
), were isolated. The structure of
seco
-dehydroantofine B was elucidated by performing comprehensive one- and two-dimensional nuclear magnetic resonance spectroscopy and high-resolution electrospray ionization mass spectrometry. The cytotoxicity of these compounds against five human tumor cell lines was evaluated. Compound
3
exhibited anti-tumor activity at IC
50
values of 50.0, 66.9, 50.0, and 153.7 µM against MKN1, SAS, HL-60, and THP-1 cells, respectively. |
| doi_str_mv | 10.1007/s11418-022-01610-9 |
| format | Article |
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Boehmeria sieboldiana
leaves against human cancer cell lines were isolated in the present study. After purification of the extract,
seco
-dehydroantofine B (
1
) together with two known phenanthroindolizine alkaloids,
seco
-dehydroantofine A (
2
) and septicine (
3
), were isolated. The structure of
seco
-dehydroantofine B was elucidated by performing comprehensive one- and two-dimensional nuclear magnetic resonance spectroscopy and high-resolution electrospray ionization mass spectrometry. The cytotoxicity of these compounds against five human tumor cell lines was evaluated. Compound
3
exhibited anti-tumor activity at IC
50
values of 50.0, 66.9, 50.0, and 153.7 µM against MKN1, SAS, HL-60, and THP-1 cells, respectively.</description><identifier>ISSN: 1340-3443</identifier><identifier>EISSN: 1861-0293</identifier><identifier>DOI: 10.1007/s11418-022-01610-9</identifier><identifier>PMID: 35249209</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Alkaloids ; Antitumor agents ; Biomedical and Life Sciences ; Biomedicine ; Boehmeria ; Complementary & Alternative Medicine ; Cytotoxicity ; Ions ; Leaves ; Magnetic resonance spectroscopy ; Mass spectroscopy ; Medicinal Chemistry ; Medicinal plants ; NMR ; Nuclear magnetic resonance ; Pharmacology/Toxicology ; Pharmacy ; Phytochemicals ; Plant Sciences ; Tumor cell lines ; Tumors</subject><ispartof>Journal of natural medicines, 2022-06, Vol.76 (3), p.670-674</ispartof><rights>The Author(s) under exclusive licence to The Japanese Society of Pharmacognosy 2022</rights><rights>2022. The Author(s) under exclusive licence to The Japanese Society of Pharmacognosy.</rights><rights>The Author(s) under exclusive licence to The Japanese Society of Pharmacognosy 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-af7633db58c2016e9997d93cbece56c233174d6f8580f9286a56538b7bd390883</citedby><cites>FETCH-LOGICAL-c426t-af7633db58c2016e9997d93cbece56c233174d6f8580f9286a56538b7bd390883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11418-022-01610-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11418-022-01610-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35249209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsuo, Hirotaka</creatorcontrib><creatorcontrib>Kawakami, Hitomi</creatorcontrib><creatorcontrib>Anjiki, Naoko</creatorcontrib><creatorcontrib>Kawano, Noriaki</creatorcontrib><creatorcontrib>Fuchino, Hiroyuki</creatorcontrib><creatorcontrib>Kawahara, Nobuo</creatorcontrib><creatorcontrib>Yoshimatsu, Kayo</creatorcontrib><title>Phenanthroindolizine alkaloids from Boehmeria sieboldiana leaves exhibit cytotoxicity against human cancer cell lines</title><title>Journal of natural medicines</title><addtitle>J Nat Med</addtitle><addtitle>J Nat Med</addtitle><description>To explore useful natural compounds from indigenous medicinal plants, the cytotoxic properties from a methanolic extract of
Boehmeria sieboldiana
leaves against human cancer cell lines were isolated in the present study. After purification of the extract,
seco
-dehydroantofine B (
1
) together with two known phenanthroindolizine alkaloids,
seco
-dehydroantofine A (
2
) and septicine (
3
), were isolated. The structure of
seco
-dehydroantofine B was elucidated by performing comprehensive one- and two-dimensional nuclear magnetic resonance spectroscopy and high-resolution electrospray ionization mass spectrometry. The cytotoxicity of these compounds against five human tumor cell lines was evaluated. Compound
3
exhibited anti-tumor activity at IC
50
values of 50.0, 66.9, 50.0, and 153.7 µM against MKN1, SAS, HL-60, and THP-1 cells, respectively.</description><subject>Alkaloids</subject><subject>Antitumor agents</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Boehmeria</subject><subject>Complementary & Alternative Medicine</subject><subject>Cytotoxicity</subject><subject>Ions</subject><subject>Leaves</subject><subject>Magnetic resonance spectroscopy</subject><subject>Mass spectroscopy</subject><subject>Medicinal Chemistry</subject><subject>Medicinal plants</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Phytochemicals</subject><subject>Plant Sciences</subject><subject>Tumor cell lines</subject><subject>Tumors</subject><issn>1340-3443</issn><issn>1861-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kU1vFSEUhonR9OPaP-DCkLhxM5WvYWCpjf1ImuhC14RhznSoDFSYaXr99XK91SYuuoLAc17O4UHoDSWnlJDuQ6FUUNUQxhpCJSWNfoGOqJK0Hmn-su65IA0Xgh-i41JuCRGMc3qADnnLhGZEH6H16wTRxmXKycchBf_LR8A2_LAh-aHgMacZf0owzZC9xcVDn8LgbbQ4gL2HguFh8r1fsNsuaUkP3vlli-2N9bEseFpnG7Gz0UHGDkLAoeaX1-jVaEOBk8d1g76ff_52dtlcf7m4Ovt43TjB5NLYsZOcD32rHKsTgta6GzR3PThopdsN04lBjqpVZNRMSdvKlqu-6weuiVJ8g97vc-9y-rlCWczsy64NGyGtxTDJpVKiFbSi7_5Db9OaY-2uUlJxxkT9vQ1ie8rlVEqG0dxlP9u8NZSYnRSzl2KqFPNHitG16O1j9NrPMPwr-WuhAnwPlHoVbyA_vf1M7G9oGZif</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Matsuo, Hirotaka</creator><creator>Kawakami, Hitomi</creator><creator>Anjiki, Naoko</creator><creator>Kawano, Noriaki</creator><creator>Fuchino, Hiroyuki</creator><creator>Kawahara, Nobuo</creator><creator>Yoshimatsu, Kayo</creator><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20220601</creationdate><title>Phenanthroindolizine alkaloids from Boehmeria sieboldiana leaves exhibit cytotoxicity against human cancer cell lines</title><author>Matsuo, Hirotaka ; Kawakami, Hitomi ; Anjiki, Naoko ; Kawano, Noriaki ; Fuchino, Hiroyuki ; Kawahara, Nobuo ; Yoshimatsu, Kayo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-af7633db58c2016e9997d93cbece56c233174d6f8580f9286a56538b7bd390883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alkaloids</topic><topic>Antitumor agents</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Boehmeria</topic><topic>Complementary & Alternative Medicine</topic><topic>Cytotoxicity</topic><topic>Ions</topic><topic>Leaves</topic><topic>Magnetic resonance spectroscopy</topic><topic>Mass spectroscopy</topic><topic>Medicinal Chemistry</topic><topic>Medicinal plants</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Phytochemicals</topic><topic>Plant Sciences</topic><topic>Tumor cell lines</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsuo, Hirotaka</creatorcontrib><creatorcontrib>Kawakami, Hitomi</creatorcontrib><creatorcontrib>Anjiki, Naoko</creatorcontrib><creatorcontrib>Kawano, Noriaki</creatorcontrib><creatorcontrib>Fuchino, Hiroyuki</creatorcontrib><creatorcontrib>Kawahara, Nobuo</creatorcontrib><creatorcontrib>Yoshimatsu, Kayo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsuo, Hirotaka</au><au>Kawakami, Hitomi</au><au>Anjiki, Naoko</au><au>Kawano, Noriaki</au><au>Fuchino, Hiroyuki</au><au>Kawahara, Nobuo</au><au>Yoshimatsu, Kayo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phenanthroindolizine alkaloids from Boehmeria sieboldiana leaves exhibit cytotoxicity against human cancer cell lines</atitle><jtitle>Journal of natural medicines</jtitle><stitle>J Nat Med</stitle><addtitle>J Nat Med</addtitle><date>2022-06-01</date><risdate>2022</risdate><volume>76</volume><issue>3</issue><spage>670</spage><epage>674</epage><pages>670-674</pages><issn>1340-3443</issn><eissn>1861-0293</eissn><abstract>To explore useful natural compounds from indigenous medicinal plants, the cytotoxic properties from a methanolic extract of
Boehmeria sieboldiana
leaves against human cancer cell lines were isolated in the present study. After purification of the extract,
seco
-dehydroantofine B (
1
) together with two known phenanthroindolizine alkaloids,
seco
-dehydroantofine A (
2
) and septicine (
3
), were isolated. The structure of
seco
-dehydroantofine B was elucidated by performing comprehensive one- and two-dimensional nuclear magnetic resonance spectroscopy and high-resolution electrospray ionization mass spectrometry. The cytotoxicity of these compounds against five human tumor cell lines was evaluated. Compound
3
exhibited anti-tumor activity at IC
50
values of 50.0, 66.9, 50.0, and 153.7 µM against MKN1, SAS, HL-60, and THP-1 cells, respectively.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>35249209</pmid><doi>10.1007/s11418-022-01610-9</doi><tpages>5</tpages></addata></record> |
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| subjects | Alkaloids Antitumor agents Biomedical and Life Sciences Biomedicine Boehmeria Complementary & Alternative Medicine Cytotoxicity Ions Leaves Magnetic resonance spectroscopy Mass spectroscopy Medicinal Chemistry Medicinal plants NMR Nuclear magnetic resonance Pharmacology/Toxicology Pharmacy Phytochemicals Plant Sciences Tumor cell lines Tumors |
| title | Phenanthroindolizine alkaloids from Boehmeria sieboldiana leaves exhibit cytotoxicity against human cancer cell lines |
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