Benzo(a)pyrene induces airway epithelial injury through Wnt5a-mediated non-canonical Wnt-YAP/TAZ signaling

Wnt5a is a key mediator of non-canonical Wnt signaling, and an early indicator of epithelial injury and lung dysfunction. Polycyclic aromatic hydrocarbons (PAHs) could induce acute pulmonary pathogenesis, of which the underlying mechanism remains unclear. To elucidate the potential role of Wnt5a-med...

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Veröffentlicht in:	The Science of the total environment 2022-04, Vol.815, p.151965-151965, Article 151965
Hauptverfasser:	Fan, Lieyang, Li, Wei, Ma, Jixuan, Cheng, Man, Xie, Li, Ye, Zi, Xie, Yujia, Wang, Bin, Yu, Linling, Zhou, Yun, Chen, Weihong
Format:	Artikel
Sprache:	eng
Schlagworte:	acute exposure Airway epithelial injury Animals Benzo(a)pyrene Benzo(a)pyrene - toxicity CC16 cytokines dose response environment epithelium inflammation Lung Lung inflammation Lung Injury lungs Mice pathogenesis Pneumonia toxicity Wnt Signaling Pathway Wnt5a
Online-Zugang:	Volltext
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