Protective effects of rutin against deltamethrin-induced hepatotoxicity and nephrotoxicity in rats via regulation of oxidative stress, inflammation, and apoptosis
Deltamethrin is a type-II pyrethroid synthetic insecticide that is extensively used for controlling mosquitoes, flies, pests, and insects worldwide. This study was carried out to evaluate the likelihood protective effects of rutin, a natural antioxidant, against deltamethrin-induced liver and kidney...
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| Veröffentlicht in: | Environmental science and pollution research international 2021-11, Vol.28 (44), p.62975-62990 |
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| creator | Küçükler, Sefa Kandemir, Fatih Mehmet Özdemir, Selçuk Çomaklı, Selim Caglayan, Cuneyt |
| description | Deltamethrin is a type-II pyrethroid synthetic insecticide that is extensively used for controlling mosquitoes, flies, pests, and insects worldwide. This study was carried out to evaluate the likelihood protective effects of rutin, a natural antioxidant, against deltamethrin-induced liver and kidney toxicities in rats. Hepatotoxicity and nephrotoxicity were evaluated after the rats were treated orally with deltamethrin (1.28 mg/kg b.w.) alone or with rutin (25 and 50 mg/kg b.w.) for 30 days. Deltamethrin administration caused an increase in lipid peroxidation level and a decrease in activities of SOD, CAT, GPx, and GSH levels in the both tissues. Deltamethrin also increased serum ALT, AST, ALP, urea, and creatinine levels, while reduced nephrine levels in rats. In addition, deltamethrin increased the activation of inflammatory and apoptotic pathways by decreasing Bcl-2 and increasing TNF-α, NF-κB, IL-1β, p38α MAPK, COX-2, iNOS, beclin-1, Bax, and caspase-3 protein levels and/or activities. Furthermore, deltamethrin increased mRNA expression levels of PARP-1, VEGF, and immunohistochemical expressions of c-fos in the tissues. Rutin treatment significantly improved all examined parameters and restored the liver and kidney histopathological and immunohistochemical alterations. These findings demonstrate that rutin could be used to ameliorate hepatotoxicity and nephrotoxicity associated with oxidative stress, inflammation, and apoptosis in deltamethrin-induced rats.
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| doi_str_mv | 10.1007/s11356-021-15190-w |
| format | Article |
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Graphical abstract</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Apoptosis</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>BAX protein</subject><subject>Bcl-2 protein</subject><subject>blood serum</subject><subject>c-Fos protein</subject><subject>Caspase-3</subject><subject>Chemical and Drug Induced Liver Injury - metabolism</subject><subject>Creatinine</subject><subject>Cyclooxygenase-2</subject><subject>Deltamethrin</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Evaluation</subject><subject>Gene expression</subject><subject>Hepatotoxicity</subject><subject>histopathology</subject><subject>immunohistochemistry</subject><subject>Inflammation</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - metabolism</subject><subject>Insecticides</subject><subject>Insects</subject><subject>Kidney - metabolism</subject><subject>Kidneys</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Liver</subject><subject>MAP kinase</subject><subject>nephrotoxicity</subject><subject>NF-kappa B - metabolism</subject><subject>NF-κB protein</subject><subject>Nitric-oxide synthase</subject><subject>Nitriles</subject><subject>Oxidative Stress</subject><subject>Peroxidation</subject><subject>Pests</subject><subject>Pyrethrins</subject><subject>Pyrethroids</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Research Article</subject><subject>Rutin</subject><subject>Urea</subject><subject>Vascular endothelial growth factor</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kcuOFCEUhonROO3oC7gwlbhxMSh3qKWZeEsm0YWuCc2lm0kVlEDN5XV8Upnu0UlcuOIEvvMdTn4AXmL0FiMk31WMKRcQEQwxxyOC14_ABgvMoGTj-Bhs0MgYxJSxE_Cs1kuECBqJfApOKCNYUck34Ne3kpu3LV75wYfQqzrkMJS1xTSYnYmptsH5qZnZt32JCcbkVuvdsPeLabnlm2hjux1MckPyy748XHVDMd13Fc1Q_G6dTIs53ek74cxhZm3F13rW2TCZeT4QZweZWfLSco31OXgSzFT9i_vzFPz4-OH7-Wd48fXTl_P3F9AyThokihspKcVBIc4M2zqMtqOgCgljqXRbxfv2jjHMJRLUeqasYirgYBkyRNFT8OboXUr-ufra9Byr9dNkks9r1URQwSRlo-zo63_Qy7yW1H-nCR-FwlQJ2ilypGzJtRYf9FLibMqtxkjfJaiPCeqeoD4kqK9706t79bqdvfvb8ieyDtAjUPtT2vnyMPs_2t-flKpg</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Küçükler, Sefa</creator><creator>Kandemir, Fatih Mehmet</creator><creator>Özdemir, Selçuk</creator><creator>Çomaklı, Selim</creator><creator>Caglayan, Cuneyt</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SN</scope><scope>7T7</scope><scope>7TV</scope><scope>7U7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>P64</scope><scope>PATMY</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0001-5608-554X</orcidid></search><sort><creationdate>20211101</creationdate><title>Protective effects of rutin against deltamethrin-induced hepatotoxicity and nephrotoxicity in rats via regulation of oxidative stress, inflammation, and apoptosis</title><author>Küçükler, Sefa ; Kandemir, Fatih Mehmet ; Özdemir, Selçuk ; Çomaklı, Selim ; Caglayan, Cuneyt</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-285a77331f8054a4bd10b963806ac37db85092d44157063ce48c848f1fc40a283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Apoptosis</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>BAX protein</topic><topic>Bcl-2 protein</topic><topic>blood serum</topic><topic>c-Fos protein</topic><topic>Caspase-3</topic><topic>Chemical and Drug Induced Liver Injury - metabolism</topic><topic>Creatinine</topic><topic>Cyclooxygenase-2</topic><topic>Deltamethrin</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Environmental science</topic><topic>Evaluation</topic><topic>Gene expression</topic><topic>Hepatotoxicity</topic><topic>histopathology</topic><topic>immunohistochemistry</topic><topic>Inflammation</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - metabolism</topic><topic>Insecticides</topic><topic>Insects</topic><topic>Kidney - metabolism</topic><topic>Kidneys</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Liver</topic><topic>MAP kinase</topic><topic>nephrotoxicity</topic><topic>NF-kappa B - 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Academic</collection><jtitle>Environmental science and pollution research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Küçükler, Sefa</au><au>Kandemir, Fatih Mehmet</au><au>Özdemir, Selçuk</au><au>Çomaklı, Selim</au><au>Caglayan, Cuneyt</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effects of rutin against deltamethrin-induced hepatotoxicity and nephrotoxicity in rats via regulation of oxidative stress, inflammation, and apoptosis</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>28</volume><issue>44</issue><spage>62975</spage><epage>62990</epage><pages>62975-62990</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>Deltamethrin is a type-II pyrethroid synthetic insecticide that is extensively used for controlling mosquitoes, flies, pests, and insects worldwide. This study was carried out to evaluate the likelihood protective effects of rutin, a natural antioxidant, against deltamethrin-induced liver and kidney toxicities in rats. Hepatotoxicity and nephrotoxicity were evaluated after the rats were treated orally with deltamethrin (1.28 mg/kg b.w.) alone or with rutin (25 and 50 mg/kg b.w.) for 30 days. Deltamethrin administration caused an increase in lipid peroxidation level and a decrease in activities of SOD, CAT, GPx, and GSH levels in the both tissues. Deltamethrin also increased serum ALT, AST, ALP, urea, and creatinine levels, while reduced nephrine levels in rats. In addition, deltamethrin increased the activation of inflammatory and apoptotic pathways by decreasing Bcl-2 and increasing TNF-α, NF-κB, IL-1β, p38α MAPK, COX-2, iNOS, beclin-1, Bax, and caspase-3 protein levels and/or activities. Furthermore, deltamethrin increased mRNA expression levels of PARP-1, VEGF, and immunohistochemical expressions of c-fos in the tissues. Rutin treatment significantly improved all examined parameters and restored the liver and kidney histopathological and immunohistochemical alterations. These findings demonstrate that rutin could be used to ameliorate hepatotoxicity and nephrotoxicity associated with oxidative stress, inflammation, and apoptosis in deltamethrin-induced rats.
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| subjects | Animals Antioxidants Antioxidants - metabolism Apoptosis Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution BAX protein Bcl-2 protein blood serum c-Fos protein Caspase-3 Chemical and Drug Induced Liver Injury - metabolism Creatinine Cyclooxygenase-2 Deltamethrin Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Evaluation Gene expression Hepatotoxicity histopathology immunohistochemistry Inflammation Inflammation - chemically induced Inflammation - metabolism Insecticides Insects Kidney - metabolism Kidneys Lipid peroxidation Lipids Liver MAP kinase nephrotoxicity NF-kappa B - metabolism NF-κB protein Nitric-oxide synthase Nitriles Oxidative Stress Peroxidation Pests Pyrethrins Pyrethroids Rats Rats, Sprague-Dawley Research Article Rutin Urea Vascular endothelial growth factor Waste Water Technology Water Management Water Pollution Control |
| title | Protective effects of rutin against deltamethrin-induced hepatotoxicity and nephrotoxicity in rats via regulation of oxidative stress, inflammation, and apoptosis |
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