A covalently cross-linked hyaluronic acid/bacterial cellulose composite hydrogel for potential biological applications
[Display omitted] •BC and HA were covalently crosslinked by BDDE.•Crosslinked BC/HA composites exhibited a denser and smoother surface.•BDDE crosslinking improved water retention capability, dimensional stability, and elongation at break of BC/HA composites .•Crosslinked BC/HA composites significant...
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| Veröffentlicht in: | Carbohydrate polymers 2021-01, Vol.252, p.117123-117123, Article 117123 |
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| creator | Tang, Shuo Chi, Kai Xu, Hui Yong, Qiang Yang, Jian Catchmark, Jeffrey M. |
| description | [Display omitted]
•BC and HA were covalently crosslinked by BDDE.•Crosslinked BC/HA composites exhibited a denser and smoother surface.•BDDE crosslinking improved water retention capability, dimensional stability, and elongation at break of BC/HA composites .•Crosslinked BC/HA composites significantly promoted cell proliferation.
Bacterial cellulose (BC) is a good material candidate for wound dressing because of its fine 3-D network structure, high mechanical strength and water holding capability, and good biocompatibility. In this study, a composite hydrogel was prepared by using 1,4-butanediol diglycidyl ether (BDDE) to cross-link BC and hyaluronic acid (HA). Cross-linked BC/HA composites exhibited a denser and smoother surface. This dense morphology improved water retention capability and dimensional stability. BDDE cross-linked BC/HA composite with 2% HA and 1% BDDE showed better overall properties, including water stability (12.7 % water solubility), mechanical properties (tensile strength: ∼ 0.61 MPa and Young’s modulus: ∼1.62 MPa) and thermal stability (maximum degradation temperature: 360 °C), as compared to BC/HA without crosslinking. In addition, cell toxicity assays and morphology indicated the BDDE cross-linked BC/HA composite significantly promoted cell proliferation and adhesion. This chemically cross-linked BC/HA composite may have many new biomedical applications in wound care. |
| doi_str_mv | 10.1016/j.carbpol.2020.117123 |
| format | Article |
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•BC and HA were covalently crosslinked by BDDE.•Crosslinked BC/HA composites exhibited a denser and smoother surface.•BDDE crosslinking improved water retention capability, dimensional stability, and elongation at break of BC/HA composites .•Crosslinked BC/HA composites significantly promoted cell proliferation.
Bacterial cellulose (BC) is a good material candidate for wound dressing because of its fine 3-D network structure, high mechanical strength and water holding capability, and good biocompatibility. In this study, a composite hydrogel was prepared by using 1,4-butanediol diglycidyl ether (BDDE) to cross-link BC and hyaluronic acid (HA). Cross-linked BC/HA composites exhibited a denser and smoother surface. This dense morphology improved water retention capability and dimensional stability. BDDE cross-linked BC/HA composite with 2% HA and 1% BDDE showed better overall properties, including water stability (12.7 % water solubility), mechanical properties (tensile strength: ∼ 0.61 MPa and Young’s modulus: ∼1.62 MPa) and thermal stability (maximum degradation temperature: 360 °C), as compared to BC/HA without crosslinking. In addition, cell toxicity assays and morphology indicated the BDDE cross-linked BC/HA composite significantly promoted cell proliferation and adhesion. This chemically cross-linked BC/HA composite may have many new biomedical applications in wound care.</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2020.117123</identifier><identifier>PMID: 33183589</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Acetobacteraceae - metabolism ; adhesion ; Animals ; Bacterial cellulose ; Bandages ; BDDE ; Biocompatibility ; Biocompatible Materials - chemistry ; Biocompatible Materials - pharmacology ; Biocomposite ; Butylene Glycols - chemistry ; Cell Adhesion - drug effects ; Cell Line ; cell proliferation ; Cell Proliferation - drug effects ; cellulose ; Cellulose - chemistry ; Cellulose - pharmacology ; chemical bonding ; Cross-linked hydrogel ; crosslinking ; cytotoxicity ; dimensional stability ; Elastic Modulus ; Fibroblasts ; Hyaluronic acid ; Hyaluronic Acid - chemistry ; Hyaluronic Acid - pharmacology ; hydrogels ; Hydrogels - chemistry ; Hydrogels - pharmacology ; Mice ; Solubility ; Temperature ; Tensile Strength ; thermal stability ; water solubility</subject><ispartof>Carbohydrate polymers, 2021-01, Vol.252, p.117123-117123, Article 117123</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-8da98b53ea429b748a44a2e2119e5d9765410761b1e34874d5e1bf57c9d1b20c3</citedby><cites>FETCH-LOGICAL-c511t-8da98b53ea429b748a44a2e2119e5d9765410761b1e34874d5e1bf57c9d1b20c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0144861720312960$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33183589$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tang, Shuo</creatorcontrib><creatorcontrib>Chi, Kai</creatorcontrib><creatorcontrib>Xu, Hui</creatorcontrib><creatorcontrib>Yong, Qiang</creatorcontrib><creatorcontrib>Yang, Jian</creatorcontrib><creatorcontrib>Catchmark, Jeffrey M.</creatorcontrib><title>A covalently cross-linked hyaluronic acid/bacterial cellulose composite hydrogel for potential biological applications</title><title>Carbohydrate polymers</title><addtitle>Carbohydr Polym</addtitle><description>[Display omitted]
•BC and HA were covalently crosslinked by BDDE.•Crosslinked BC/HA composites exhibited a denser and smoother surface.•BDDE crosslinking improved water retention capability, dimensional stability, and elongation at break of BC/HA composites .•Crosslinked BC/HA composites significantly promoted cell proliferation.
Bacterial cellulose (BC) is a good material candidate for wound dressing because of its fine 3-D network structure, high mechanical strength and water holding capability, and good biocompatibility. In this study, a composite hydrogel was prepared by using 1,4-butanediol diglycidyl ether (BDDE) to cross-link BC and hyaluronic acid (HA). Cross-linked BC/HA composites exhibited a denser and smoother surface. This dense morphology improved water retention capability and dimensional stability. BDDE cross-linked BC/HA composite with 2% HA and 1% BDDE showed better overall properties, including water stability (12.7 % water solubility), mechanical properties (tensile strength: ∼ 0.61 MPa and Young’s modulus: ∼1.62 MPa) and thermal stability (maximum degradation temperature: 360 °C), as compared to BC/HA without crosslinking. In addition, cell toxicity assays and morphology indicated the BDDE cross-linked BC/HA composite significantly promoted cell proliferation and adhesion. This chemically cross-linked BC/HA composite may have many new biomedical applications in wound care.</description><subject>Acetobacteraceae - metabolism</subject><subject>adhesion</subject><subject>Animals</subject><subject>Bacterial cellulose</subject><subject>Bandages</subject><subject>BDDE</subject><subject>Biocompatibility</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Biocomposite</subject><subject>Butylene Glycols - chemistry</subject><subject>Cell Adhesion - drug effects</subject><subject>Cell Line</subject><subject>cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>cellulose</subject><subject>Cellulose - chemistry</subject><subject>Cellulose - pharmacology</subject><subject>chemical bonding</subject><subject>Cross-linked hydrogel</subject><subject>crosslinking</subject><subject>cytotoxicity</subject><subject>dimensional stability</subject><subject>Elastic Modulus</subject><subject>Fibroblasts</subject><subject>Hyaluronic acid</subject><subject>Hyaluronic Acid - chemistry</subject><subject>Hyaluronic Acid - pharmacology</subject><subject>hydrogels</subject><subject>Hydrogels - chemistry</subject><subject>Hydrogels - pharmacology</subject><subject>Mice</subject><subject>Solubility</subject><subject>Temperature</subject><subject>Tensile Strength</subject><subject>thermal stability</subject><subject>water solubility</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9vEzEQxS0EomnhI4D2yGVTj-1de0-oqoBWqtQLnC3_mRQHZ73Yu5Hy7euQ0GvnMiPr92as9wj5BHQNFPrr7dqZbKcU14yy-gYSGH9DVqDk0AIX4i1ZURCiVT3IC3JZypbW6oG-Jxecg-KdGlZkf9O4tDcRxzkeGpdTKW0M4x_0ze-DiUtOY3CNccFfW-NmzMHExmGMS0wFq3Y3pRJmrLTP6Qljs0m5mdJcFx5RG1JMT8HV0UxTrMMc0lg-kHcbEwt-PPcr8uv7t5-3d-3D44_725uH1nUAc6u8GZTtOBrBBiuFMkIYhgxgwM4Psu8EUNmDBeRCSeE7BLvppBs8WEYdvyJfTnunnP4uWGa9C-X4fTNiWopmPe8Fq07I11HRUymppKqi3Qn951fGjZ5y2Jl80ED1MR291ed09DEdfUqn6j6fTyx2h_5F9T-OCnw9AVg92QfMuriAo0MfMrpZ-xReOfEM3Zak6g</recordid><startdate>20210115</startdate><enddate>20210115</enddate><creator>Tang, Shuo</creator><creator>Chi, Kai</creator><creator>Xu, Hui</creator><creator>Yong, Qiang</creator><creator>Yang, Jian</creator><creator>Catchmark, Jeffrey M.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20210115</creationdate><title>A covalently cross-linked hyaluronic acid/bacterial cellulose composite hydrogel for potential biological applications</title><author>Tang, Shuo ; Chi, Kai ; Xu, Hui ; Yong, Qiang ; Yang, Jian ; Catchmark, Jeffrey M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-8da98b53ea429b748a44a2e2119e5d9765410761b1e34874d5e1bf57c9d1b20c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acetobacteraceae - metabolism</topic><topic>adhesion</topic><topic>Animals</topic><topic>Bacterial cellulose</topic><topic>Bandages</topic><topic>BDDE</topic><topic>Biocompatibility</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biocompatible Materials - pharmacology</topic><topic>Biocomposite</topic><topic>Butylene Glycols - chemistry</topic><topic>Cell Adhesion - drug effects</topic><topic>Cell Line</topic><topic>cell proliferation</topic><topic>Cell Proliferation - drug effects</topic><topic>cellulose</topic><topic>Cellulose - chemistry</topic><topic>Cellulose - pharmacology</topic><topic>chemical bonding</topic><topic>Cross-linked hydrogel</topic><topic>crosslinking</topic><topic>cytotoxicity</topic><topic>dimensional stability</topic><topic>Elastic Modulus</topic><topic>Fibroblasts</topic><topic>Hyaluronic acid</topic><topic>Hyaluronic Acid - chemistry</topic><topic>Hyaluronic Acid - pharmacology</topic><topic>hydrogels</topic><topic>Hydrogels - chemistry</topic><topic>Hydrogels - pharmacology</topic><topic>Mice</topic><topic>Solubility</topic><topic>Temperature</topic><topic>Tensile Strength</topic><topic>thermal stability</topic><topic>water solubility</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tang, Shuo</creatorcontrib><creatorcontrib>Chi, Kai</creatorcontrib><creatorcontrib>Xu, Hui</creatorcontrib><creatorcontrib>Yong, Qiang</creatorcontrib><creatorcontrib>Yang, Jian</creatorcontrib><creatorcontrib>Catchmark, Jeffrey M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, Shuo</au><au>Chi, Kai</au><au>Xu, Hui</au><au>Yong, Qiang</au><au>Yang, Jian</au><au>Catchmark, Jeffrey M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A covalently cross-linked hyaluronic acid/bacterial cellulose composite hydrogel for potential biological applications</atitle><jtitle>Carbohydrate polymers</jtitle><addtitle>Carbohydr Polym</addtitle><date>2021-01-15</date><risdate>2021</risdate><volume>252</volume><spage>117123</spage><epage>117123</epage><pages>117123-117123</pages><artnum>117123</artnum><issn>0144-8617</issn><eissn>1879-1344</eissn><abstract>[Display omitted]
•BC and HA were covalently crosslinked by BDDE.•Crosslinked BC/HA composites exhibited a denser and smoother surface.•BDDE crosslinking improved water retention capability, dimensional stability, and elongation at break of BC/HA composites .•Crosslinked BC/HA composites significantly promoted cell proliferation.
Bacterial cellulose (BC) is a good material candidate for wound dressing because of its fine 3-D network structure, high mechanical strength and water holding capability, and good biocompatibility. In this study, a composite hydrogel was prepared by using 1,4-butanediol diglycidyl ether (BDDE) to cross-link BC and hyaluronic acid (HA). Cross-linked BC/HA composites exhibited a denser and smoother surface. This dense morphology improved water retention capability and dimensional stability. BDDE cross-linked BC/HA composite with 2% HA and 1% BDDE showed better overall properties, including water stability (12.7 % water solubility), mechanical properties (tensile strength: ∼ 0.61 MPa and Young’s modulus: ∼1.62 MPa) and thermal stability (maximum degradation temperature: 360 °C), as compared to BC/HA without crosslinking. In addition, cell toxicity assays and morphology indicated the BDDE cross-linked BC/HA composite significantly promoted cell proliferation and adhesion. This chemically cross-linked BC/HA composite may have many new biomedical applications in wound care.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>33183589</pmid><doi>10.1016/j.carbpol.2020.117123</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetobacteraceae - metabolism adhesion Animals Bacterial cellulose Bandages BDDE Biocompatibility Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Biocomposite Butylene Glycols - chemistry Cell Adhesion - drug effects Cell Line cell proliferation Cell Proliferation - drug effects cellulose Cellulose - chemistry Cellulose - pharmacology chemical bonding Cross-linked hydrogel crosslinking cytotoxicity dimensional stability Elastic Modulus Fibroblasts Hyaluronic acid Hyaluronic Acid - chemistry Hyaluronic Acid - pharmacology hydrogels Hydrogels - chemistry Hydrogels - pharmacology Mice Solubility Temperature Tensile Strength thermal stability water solubility |
| title | A covalently cross-linked hyaluronic acid/bacterial cellulose composite hydrogel for potential biological applications |
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