An updated review on the potential antineoplastic actions of oleuropein
Oleuropein is an ester of elenolic acid and hydroxytyrosol (3, 4‐dihydroxyphenylethanol). It is a phenolic compound and the most luxuriant in olives. The detailed information related to the anticancer effects of oleuropein was collected from the internet database PubMed/Medline, ResearchGate, Web of...
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| Veröffentlicht in: | Phytotherapy research 2022-01, Vol.36 (1), p.365-379 |
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| creator | Zheng, Yudong Liu, Zhenzhen Yang, Xiulan Liu, Lian Ahn, Kwang Seok |
| description | Oleuropein is an ester of elenolic acid and hydroxytyrosol (3, 4‐dihydroxyphenylethanol). It is a phenolic compound and the most luxuriant in olives. The detailed information related to the anticancer effects of oleuropein was collected from the internet database PubMed/Medline, ResearchGate, Web of Science, Wiley Online Library, and Cnki using appropriate keywords until the end of October 2021. Oleuropein has been shown to have antioxidant, anticancer, antiinflammatory, cardioprotective, neuroprotective, and hepatoprotective effects. Previous studies also revealed that oleuropein could effectively inhibit the malignant progression of esophageal cancer, gastric cancer, breast cancer, lung cancer, liver cancer, pancreatic cancer, ovarian cancer, prostate cancer, and cervical cancer. Recently, the role of oleuropein in inhibiting tumor cell proliferation, invasion, and migration and inducing tumor cell apoptosis has gained extensive attention. In this review, we have summarized the latest research progress related to the antioncogenic mechanisms and the potential role of oleuropein in targeting different human malignancies. Based on these findings, it can be concluded that oleuropein can function as a promising chemopreventive and chemotherapeutic agent against cancer, but its more detailed anticancer effects and underlying mechanisms need to be further validated in future preclinical as well as clinical studies. |
| doi_str_mv | 10.1002/ptr.7325 |
| format | Article |
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It is a phenolic compound and the most luxuriant in olives. The detailed information related to the anticancer effects of oleuropein was collected from the internet database PubMed/Medline, ResearchGate, Web of Science, Wiley Online Library, and Cnki using appropriate keywords until the end of October 2021. Oleuropein has been shown to have antioxidant, anticancer, antiinflammatory, cardioprotective, neuroprotective, and hepatoprotective effects. Previous studies also revealed that oleuropein could effectively inhibit the malignant progression of esophageal cancer, gastric cancer, breast cancer, lung cancer, liver cancer, pancreatic cancer, ovarian cancer, prostate cancer, and cervical cancer. Recently, the role of oleuropein in inhibiting tumor cell proliferation, invasion, and migration and inducing tumor cell apoptosis has gained extensive attention. In this review, we have summarized the latest research progress related to the antioncogenic mechanisms and the potential role of oleuropein in targeting different human malignancies. Based on these findings, it can be concluded that oleuropein can function as a promising chemopreventive and chemotherapeutic agent against cancer, but its more detailed anticancer effects and underlying mechanisms need to be further validated in future preclinical as well as clinical studies.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.7325</identifier><identifier>PMID: 34808696</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Anticancer properties ; antineoplastic ; Antineoplastic Agents ; Antioxidants ; Apoptosis ; Breast cancer ; breast neoplasms ; Cancer ; cell apoptosis ; Cell migration ; Cell proliferation ; Cervical cancer ; Cervix ; chemoprevention ; drug therapy ; Esophageal cancer ; esophageal neoplasms ; Esophagus ; Gastric cancer ; Humans ; Internet ; Iridoid Glucosides ; Iridoids - pharmacology ; Liver cancer ; liver neoplasms ; Lung cancer ; lung neoplasms ; Male ; molecular mechanism ; neoplasm cells ; Neuroprotection ; Oleuropein ; Olives ; Ovarian cancer ; ovarian neoplasms ; Pancreatic cancer ; Pancreatic Neoplasms ; Phenolic compounds ; Phenols ; phytotherapy ; Prostate cancer ; prostatic neoplasms ; stomach neoplasms ; Tumors ; uterine cervical neoplasms</subject><ispartof>Phytotherapy research, 2022-01, Vol.36 (1), p.365-379</ispartof><rights>2021 John Wiley & Sons Ltd.</rights><rights>2022 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3825-a70cb3b29aa97d572530efb8ed3fac2aefa1d81585fb94a98d60eac25c0cecdd3</citedby><cites>FETCH-LOGICAL-c3825-a70cb3b29aa97d572530efb8ed3fac2aefa1d81585fb94a98d60eac25c0cecdd3</cites><orcidid>0000-0002-2882-0612</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.7325$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.7325$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34808696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zheng, Yudong</creatorcontrib><creatorcontrib>Liu, Zhenzhen</creatorcontrib><creatorcontrib>Yang, Xiulan</creatorcontrib><creatorcontrib>Liu, Lian</creatorcontrib><creatorcontrib>Ahn, Kwang Seok</creatorcontrib><title>An updated review on the potential antineoplastic actions of oleuropein</title><title>Phytotherapy research</title><addtitle>Phytother Res</addtitle><description>Oleuropein is an ester of elenolic acid and hydroxytyrosol (3, 4‐dihydroxyphenylethanol). It is a phenolic compound and the most luxuriant in olives. The detailed information related to the anticancer effects of oleuropein was collected from the internet database PubMed/Medline, ResearchGate, Web of Science, Wiley Online Library, and Cnki using appropriate keywords until the end of October 2021. Oleuropein has been shown to have antioxidant, anticancer, antiinflammatory, cardioprotective, neuroprotective, and hepatoprotective effects. Previous studies also revealed that oleuropein could effectively inhibit the malignant progression of esophageal cancer, gastric cancer, breast cancer, lung cancer, liver cancer, pancreatic cancer, ovarian cancer, prostate cancer, and cervical cancer. Recently, the role of oleuropein in inhibiting tumor cell proliferation, invasion, and migration and inducing tumor cell apoptosis has gained extensive attention. In this review, we have summarized the latest research progress related to the antioncogenic mechanisms and the potential role of oleuropein in targeting different human malignancies. Based on these findings, it can be concluded that oleuropein can function as a promising chemopreventive and chemotherapeutic agent against cancer, but its more detailed anticancer effects and underlying mechanisms need to be further validated in future preclinical as well as clinical studies.</description><subject>Anticancer properties</subject><subject>antineoplastic</subject><subject>Antineoplastic Agents</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Breast cancer</subject><subject>breast neoplasms</subject><subject>Cancer</subject><subject>cell apoptosis</subject><subject>Cell migration</subject><subject>Cell proliferation</subject><subject>Cervical cancer</subject><subject>Cervix</subject><subject>chemoprevention</subject><subject>drug therapy</subject><subject>Esophageal cancer</subject><subject>esophageal neoplasms</subject><subject>Esophagus</subject><subject>Gastric cancer</subject><subject>Humans</subject><subject>Internet</subject><subject>Iridoid Glucosides</subject><subject>Iridoids - pharmacology</subject><subject>Liver cancer</subject><subject>liver neoplasms</subject><subject>Lung cancer</subject><subject>lung neoplasms</subject><subject>Male</subject><subject>molecular mechanism</subject><subject>neoplasm cells</subject><subject>Neuroprotection</subject><subject>Oleuropein</subject><subject>Olives</subject><subject>Ovarian cancer</subject><subject>ovarian neoplasms</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms</subject><subject>Phenolic compounds</subject><subject>Phenols</subject><subject>phytotherapy</subject><subject>Prostate cancer</subject><subject>prostatic neoplasms</subject><subject>stomach neoplasms</subject><subject>Tumors</subject><subject>uterine cervical neoplasms</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkdFKHTEQhoNU9NQKfYIS6I03qzPJZje5FKlaECpyhN4t2WSWruzZbJPdim9v9KiFQsGr_2I-PmbmZ-wzwjECiJNpjse1FGqHrRCMKVDV8gNbgVFYlKh_7rOPKd0BgBFQ7rF9WWrQlalW7OJ05Mvk7UyeR_rT0z0PI59_EZ_CTOPc24HbHCOFabBp7h23bu7DmHjoeBhoiWGifvzEdjs7JDp8yQN2e_5tfXZZXP24-H52elU4qYUqbA2ula0w1praq1ooCdS1mrzsrBOWOoteo9Kqa01pjfYVUB4oB46c9_KAHW29Uwy_F0pzs-mTo2GwecMlNaKSVYmmUvodKGCpEQEz-vUf9C4sccyHZEpgiaWq8a_QxZBSpK6ZYr-x8aFBaJ56aHIPzVMPGf3yIlzaDfk38PXxGSi2wH0_0MN_Rc31-uZZ-AhTiJG9</recordid><startdate>202201</startdate><enddate>202201</enddate><creator>Zheng, Yudong</creator><creator>Liu, Zhenzhen</creator><creator>Yang, Xiulan</creator><creator>Liu, Lian</creator><creator>Ahn, Kwang Seok</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-2882-0612</orcidid></search><sort><creationdate>202201</creationdate><title>An updated review on the potential antineoplastic actions of oleuropein</title><author>Zheng, Yudong ; Liu, Zhenzhen ; Yang, Xiulan ; Liu, Lian ; Ahn, Kwang Seok</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3825-a70cb3b29aa97d572530efb8ed3fac2aefa1d81585fb94a98d60eac25c0cecdd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anticancer properties</topic><topic>antineoplastic</topic><topic>Antineoplastic Agents</topic><topic>Antioxidants</topic><topic>Apoptosis</topic><topic>Breast cancer</topic><topic>breast neoplasms</topic><topic>Cancer</topic><topic>cell apoptosis</topic><topic>Cell migration</topic><topic>Cell proliferation</topic><topic>Cervical cancer</topic><topic>Cervix</topic><topic>chemoprevention</topic><topic>drug therapy</topic><topic>Esophageal cancer</topic><topic>esophageal neoplasms</topic><topic>Esophagus</topic><topic>Gastric cancer</topic><topic>Humans</topic><topic>Internet</topic><topic>Iridoid Glucosides</topic><topic>Iridoids - pharmacology</topic><topic>Liver cancer</topic><topic>liver neoplasms</topic><topic>Lung cancer</topic><topic>lung neoplasms</topic><topic>Male</topic><topic>molecular mechanism</topic><topic>neoplasm cells</topic><topic>Neuroprotection</topic><topic>Oleuropein</topic><topic>Olives</topic><topic>Ovarian cancer</topic><topic>ovarian neoplasms</topic><topic>Pancreatic cancer</topic><topic>Pancreatic Neoplasms</topic><topic>Phenolic compounds</topic><topic>Phenols</topic><topic>phytotherapy</topic><topic>Prostate cancer</topic><topic>prostatic neoplasms</topic><topic>stomach neoplasms</topic><topic>Tumors</topic><topic>uterine cervical neoplasms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Yudong</creatorcontrib><creatorcontrib>Liu, Zhenzhen</creatorcontrib><creatorcontrib>Yang, Xiulan</creatorcontrib><creatorcontrib>Liu, Lian</creatorcontrib><creatorcontrib>Ahn, Kwang Seok</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Yudong</au><au>Liu, Zhenzhen</au><au>Yang, Xiulan</au><au>Liu, Lian</au><au>Ahn, Kwang Seok</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An updated review on the potential antineoplastic actions of oleuropein</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother Res</addtitle><date>2022-01</date><risdate>2022</risdate><volume>36</volume><issue>1</issue><spage>365</spage><epage>379</epage><pages>365-379</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>Oleuropein is an ester of elenolic acid and hydroxytyrosol (3, 4‐dihydroxyphenylethanol). It is a phenolic compound and the most luxuriant in olives. The detailed information related to the anticancer effects of oleuropein was collected from the internet database PubMed/Medline, ResearchGate, Web of Science, Wiley Online Library, and Cnki using appropriate keywords until the end of October 2021. Oleuropein has been shown to have antioxidant, anticancer, antiinflammatory, cardioprotective, neuroprotective, and hepatoprotective effects. Previous studies also revealed that oleuropein could effectively inhibit the malignant progression of esophageal cancer, gastric cancer, breast cancer, lung cancer, liver cancer, pancreatic cancer, ovarian cancer, prostate cancer, and cervical cancer. Recently, the role of oleuropein in inhibiting tumor cell proliferation, invasion, and migration and inducing tumor cell apoptosis has gained extensive attention. In this review, we have summarized the latest research progress related to the antioncogenic mechanisms and the potential role of oleuropein in targeting different human malignancies. Based on these findings, it can be concluded that oleuropein can function as a promising chemopreventive and chemotherapeutic agent against cancer, but its more detailed anticancer effects and underlying mechanisms need to be further validated in future preclinical as well as clinical studies.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>34808696</pmid><doi>10.1002/ptr.7325</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-2882-0612</orcidid></addata></record> |
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| subjects | Anticancer properties antineoplastic Antineoplastic Agents Antioxidants Apoptosis Breast cancer breast neoplasms Cancer cell apoptosis Cell migration Cell proliferation Cervical cancer Cervix chemoprevention drug therapy Esophageal cancer esophageal neoplasms Esophagus Gastric cancer Humans Internet Iridoid Glucosides Iridoids - pharmacology Liver cancer liver neoplasms Lung cancer lung neoplasms Male molecular mechanism neoplasm cells Neuroprotection Oleuropein Olives Ovarian cancer ovarian neoplasms Pancreatic cancer Pancreatic Neoplasms Phenolic compounds Phenols phytotherapy Prostate cancer prostatic neoplasms stomach neoplasms Tumors uterine cervical neoplasms |
| title | An updated review on the potential antineoplastic actions of oleuropein |
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