Biochemical and biophysical characterization of PADI4 supports its involvement in cancer

PADI4 (protein-arginine deiminase, also known as protein l-arginine iminohydrolase) is one of the human isoforms of a family of Ca2+-dependent proteins catalyzing the conversion of arginine to citrulline. Although the consequences of this process, known as citrullination, are not fully understood, a...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2022-03, Vol.717, p.109125-109125, Article 109125
Hauptverfasser:	Neira, José L., Araujo-Abad, Salomé, Cámara-Artigas, Ana, Rizzuti, Bruno, Abian, Olga, Giudici, Ana Marcela, Velazquez-Campoy, Adrian, de Juan Romero, Camino
Format:	Artikel
Sprache:	eng
Schlagworte:	arginine Arginine - metabolism Biomarkers, Tumor - metabolism biophysics calcium Calorimetry Cancer carcinogenesis Carcinogenesis - metabolism Catalysis Cell Differentiation Cell Line, Tumor cell lines Circular dichroism citrulline Citrulline - metabolism computer simulation Fluorescence Gene Expression Regulation granulocytes histones Humans macrophages molecular dynamics Molecular Dynamics Simulation monocytes neoplasm cells Protein Binding Protein Processing, Post-Translational Protein stability protein-arginine deiminase Protein-Arginine Deiminase Type 4 - metabolism Protein-Arginine Deiminases - metabolism Signal Transduction Tumor Suppressor Protein p53 - metabolism Western blot
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