Role of Energy Metabolism and Mitochondrial Function in Inflammatory Bowel Disease

Abstract Inflammatory bowel disease (IBD) is a chronic recurring inflammation of the intestine which can be debilitating for those with intractable disease. However, the etiopathogenesis of inflammatory bowel disorders remains to be solved. The hypothesis that mitochondrial dysfunction is a crucial...

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Veröffentlicht in:Inflammatory bowel diseases 2022-09, Vol.28 (9), p.1443-1450
Hauptverfasser: Özsoy, Mihriban, Stummer, Nathalie, Zimmermann, Franz A, Feichtinger, René G, Sperl, Wolfgang, Weghuber, Daniel, Schneider, Anna M
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container_end_page 1450
container_issue 9
container_start_page 1443
container_title Inflammatory bowel diseases
container_volume 28
creator Özsoy, Mihriban
Stummer, Nathalie
Zimmermann, Franz A
Feichtinger, René G
Sperl, Wolfgang
Weghuber, Daniel
Schneider, Anna M
description Abstract Inflammatory bowel disease (IBD) is a chronic recurring inflammation of the intestine which can be debilitating for those with intractable disease. However, the etiopathogenesis of inflammatory bowel disorders remains to be solved. The hypothesis that mitochondrial dysfunction is a crucial factor in the disease process is being validated by an increasing number of recent studies. Thus mitochondrial alteration in conjunction with previously identified genetic predisposition, changes in the immune response, altered gut microbiota, and environmental factors (eg, diet, smoking, and lifestyle) are all posited to contribute to IBD. The implicated factors seem to affect mitochondrial function or are influenced by mitochondrial dysfunction, which explains many of the hallmarks of the disease. This review summarizes the results of studies reporting links between mitochondria and IBD that were available on PubMed through March 2021. The aim of this review is to give an overview of the current understanding of the role of mitochondria in the pathogenesis of IBD. Lay Summary We address the effect of energy metabolism and mitochondrial function on the pathogenesis of inflammatory bowel disease. Because many studies on this topic have been published recently, it is important to give an overview of the results of that work.
doi_str_mv 10.1093/ibd/izac024
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source Oxford University Press Journals All Titles (1996-Current)
title Role of Energy Metabolism and Mitochondrial Function in Inflammatory Bowel Disease
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