Characterization of embB mutations involved in ethambutol resistance in multi-drug resistant Mycobacterium tuberculosis isolates in Zambia

Ethambutol (EMB) is an important anti-tuberculosis drug used in the management of multi-drug resistant tuberculosis (MDR-TB). Mutations in embB are the major mechanism of resistance. This study investigated embB mutations among MDR-TB isolates and analyzed their correlations with phenotypic drug sus...

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Veröffentlicht in:	Tuberculosis (Edinburgh, Scotland) Scotland), 2022-03, Vol.133, p.102184-102184, Article 102184
Hauptverfasser:	Bwalya, Precious, Solo, Eddie S., Chizimu, Joseph Y., Shrestha, Dipti, Mbulo, Grace, Thapa, Jeewan, Nakajima, Chie, Suzuki, Yasuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid substitution Amino acids Antitubercular Agents - metabolism Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use DNA sequencing Drug resistance embB mutations Ethambutol Ethambutol - pharmacology Ethambutol - therapeutic use Humans Microbial Sensitivity Tests Multi-drug resistance Multidrug resistance Mutation Mycobacterium tuberculosis Pentosyltransferases - genetics Spoligotyping Tuberculosis Tuberculosis, Multidrug-Resistant - diagnosis Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - genetics Zambia Zambia - epidemiology
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