Selective inhibitors of bromodomain BD1 and BD2 of BET proteins modulate radiation‐induced profibrotic fibroblast responses

Radiotherapy can induce various adverse effects including fibrosis in cancer patients. Radiation‐induced aberrant expression of profibrotic genes has been associated with dysregulated epigenetic mechanisms. Pan‐BET (bromodomain and extraterminal domain) inhibitors, such as JQ1 and I‐BET151, have bee...

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Veröffentlicht in:	International journal of cancer 2022-07, Vol.151 (2), p.275-286
Hauptverfasser:	Liu, Chun‐Shan, Rioja, Inmaculada, Bakr, Ali, Veldwijk, Marlon R., Sperk, Elena, Herskind, Carsten, Weichenhan, Dieter, Prinjha, Rab K., Plass, Christoph, Schmezer, Peter, Popanda, Odilia
Format:	Artikel
Sprache:	eng
Schlagworte:	BET Cancer Cell cycle Cell migration Cell proliferation Collagen (type I) Cytotoxicity Epigenetics Extracellular matrix fibroblast activation Fibroblasts Fibrosis Medical research radiation Radiation therapy selective bromodomain inhibitors
Online-Zugang:	Volltext
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