Perturbation of monoamine metabolism and enhanced fear responses in mice defective in the regeneration of tetrahydrobiopterin

Increasing evidence suggests the involvement of peripheral amino acid metabolism in the pathophysiology of neuropsychiatric disorders, whereas the molecular mechanisms are largely unknown. Tetrahydrobiopterin (BH4) is a cofactor for enzymes that catalyze phenylalanine metabolism, monoamine synthesis...

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Veröffentlicht in:	Journal of neurochemistry 2022-04, Vol.161 (2), p.129-145
Hauptverfasser:	Miyajima, Katsuya, Sudo, Yusuke, Sanechika, Sho, Hara, Yoshitaka, Horiguchi, Mieko, Xu, Feng, Suzuki, Minori, Hara, Satoshi, Tanda, Koichi, Inoue, Ken‐ichi, Takada, Masahiko, Yoshioka, Nozomu, Takebayashi, Hirohide, Mori‐Kojima, Masayo, Sugimoto, Masahiro, Sumi‐Ichinose, Chiho, Kondo, Kazunao, Takao, Keizo, Miyakawa, Tsuyoshi, Ichinose, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals aromatic amino acid hydroxylases Biopterins - analogs & derivatives Biopterins - metabolism Brain Chemical synthesis Diet Dihydropteridine Reductase Disorders Fear Footshock Humans hyperphenylalaninemia Lipid metabolism Lipids Mental disorders Metabolism Mice Molecular modelling monoamine neurotransmitters Nitric oxide Oligodendrocytes Perturbation Phenylalanine Phenylketonurias - genetics Phenylketonurias - metabolism quinonoid dihydropteridine reductase Reductases Regeneration Tetrahydrobiopterin
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