Comparison of cytopathologic findings in patients with negative Pap test and positive high-risk HPV infection among three groups
Purpose Comparison of colposcopy-guided biopsy and endocervical cytologic (ECC) results in patients with negative Papanicolaou (Pap) and positive high-risk (HR) HPV tests in the three groups of HPV 16/18, non-16/18 HR-HPV (other HR-HPV), and concurrent infection of either HPV 16/18 and at least one...
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| Veröffentlicht in: | Archives of gynecology and obstetrics 2022-09, Vol.306 (3), p.857-863 |
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| container_title | Archives of gynecology and obstetrics |
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| creator | Kasraei, Sara Ghahghaei-nezamabadi, Akram Seifollahi, Akram Aghajani, Faezeh Nakhostin-Ansari, Amin Zarei, Neda Tehranian, Afsaneh |
| description | Purpose
Comparison of colposcopy-guided biopsy and endocervical cytologic (ECC) results in patients with negative Papanicolaou (Pap) and positive high-risk (HR) HPV tests in the three groups of HPV 16/18, non-16/18 HR-HPV (other HR-HPV), and concurrent infection of either HPV 16/18 and at least one subtype of other HR-HPVs.
Methods
This cross-sectional study was conducted among women aged 30–65 who had negative Pap and positive HR-HPV DNA tests. Pap test was performed using liquid cytology. For HPV DNA testing, the polymerase chain reaction (PCR) method was used.
Results
Among 394 participants, 111 (28.2%) were in the HPV 16/18, 226 (57.4%) in the Other HR-HPV, and 57 (14.4%) in the concurrent group. The mean age of participants was 35.71 ± 7.1 years. Cervical intraepithelial neoplasia (CIN) grade 2/3 were seen in 29 (26.1%) patients of HPV 16/18, 60 (26.5%) of other HR-HPV, and 18 (31.6%) of concurrent infection group (
P
= 0.593). HPV 52 was the most common subtype in the other HR-HPV group (15%).
Conclusions
The risk of high-grade CIN lesions in patients with negative Pap test and positive other HR-HPV was not significantly less than patients with positive HPV 16/18. Besides, the risk of losing the patients to 1-year follow-up seems high. |
| doi_str_mv | 10.1007/s00404-022-06444-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2635248945</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2635248945</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-2ce3b459beb41f21fe1687d679365077efc7ae6f2601fa81cb68b9994e2b96143</originalsourceid><addsrcrecordid>eNp9UU1v1TAQtBCIlsIf4IAsceESsB3HTo7oCShSJXoArpbjt05cXuxgO0W98dNZ-sqHOHDy7npmdjVDyFPOXnLG9KvCmGSyYUI0TEmJ1T1yymWLreb8_l_1CXlUyhVjXPS9ekhO2k60rVLqlHzfpWW1OZQUafLU3dS02jqnQ5qCoz7EfYhToSFSHAeItdBvoc40woT9NdBLu9IKpVIb93RNJdxO5zDNDap-oeeXn5HtwdWAK-yS4kTrnAHolNO2lsfkgbeHAk_u3jPy6e2bj7vz5uLDu_e71xeNa4WqjXDQjrIbRhgl94J74KrXe6WHVnVMa_BOW1BeKMa97bkbVT8OwyBBjINCI87Ii6PumtPXDQ82SygODgcbIW3FCIWmyH6QHUKf_wO9SluOeJ0RGp0eOq4VosQR5XIqJYM3aw6LzTeGM_MzH3PMx2A-5jYfw5D07E56GxfY_6b8CgQB7RFQ8CtOkP_s_o_sDyPxnDE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2706495176</pqid></control><display><type>article</type><title>Comparison of cytopathologic findings in patients with negative Pap test and positive high-risk HPV infection among three groups</title><source>SpringerLink Journals</source><creator>Kasraei, Sara ; Ghahghaei-nezamabadi, Akram ; Seifollahi, Akram ; Aghajani, Faezeh ; Nakhostin-Ansari, Amin ; Zarei, Neda ; Tehranian, Afsaneh</creator><creatorcontrib>Kasraei, Sara ; Ghahghaei-nezamabadi, Akram ; Seifollahi, Akram ; Aghajani, Faezeh ; Nakhostin-Ansari, Amin ; Zarei, Neda ; Tehranian, Afsaneh</creatorcontrib><description>Purpose
Comparison of colposcopy-guided biopsy and endocervical cytologic (ECC) results in patients with negative Papanicolaou (Pap) and positive high-risk (HR) HPV tests in the three groups of HPV 16/18, non-16/18 HR-HPV (other HR-HPV), and concurrent infection of either HPV 16/18 and at least one subtype of other HR-HPVs.
Methods
This cross-sectional study was conducted among women aged 30–65 who had negative Pap and positive HR-HPV DNA tests. Pap test was performed using liquid cytology. For HPV DNA testing, the polymerase chain reaction (PCR) method was used.
Results
Among 394 participants, 111 (28.2%) were in the HPV 16/18, 226 (57.4%) in the Other HR-HPV, and 57 (14.4%) in the concurrent group. The mean age of participants was 35.71 ± 7.1 years. Cervical intraepithelial neoplasia (CIN) grade 2/3 were seen in 29 (26.1%) patients of HPV 16/18, 60 (26.5%) of other HR-HPV, and 18 (31.6%) of concurrent infection group (
P
= 0.593). HPV 52 was the most common subtype in the other HR-HPV group (15%).
Conclusions
The risk of high-grade CIN lesions in patients with negative Pap test and positive other HR-HPV was not significantly less than patients with positive HPV 16/18. Besides, the risk of losing the patients to 1-year follow-up seems high.</description><identifier>ISSN: 1432-0711</identifier><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-022-06444-0</identifier><identifier>PMID: 35233666</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Endocrinology ; Gynecologic Oncology ; Gynecology ; Human Genetics ; Human papillomavirus ; Infections ; Medicine ; Medicine & Public Health ; Obstetrics/Perinatology/Midwifery ; Pap smear</subject><ispartof>Archives of gynecology and obstetrics, 2022-09, Vol.306 (3), p.857-863</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-2ce3b459beb41f21fe1687d679365077efc7ae6f2601fa81cb68b9994e2b96143</cites><orcidid>0000-0001-9119-9593 ; 0000-0002-9019-3904 ; 0000-0001-7090-8426 ; 0000-0002-3594-711X ; 0000-0002-1113-9257 ; 0000-0002-1198-6886 ; 0000-0003-4356-1038</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00404-022-06444-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00404-022-06444-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35233666$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kasraei, Sara</creatorcontrib><creatorcontrib>Ghahghaei-nezamabadi, Akram</creatorcontrib><creatorcontrib>Seifollahi, Akram</creatorcontrib><creatorcontrib>Aghajani, Faezeh</creatorcontrib><creatorcontrib>Nakhostin-Ansari, Amin</creatorcontrib><creatorcontrib>Zarei, Neda</creatorcontrib><creatorcontrib>Tehranian, Afsaneh</creatorcontrib><title>Comparison of cytopathologic findings in patients with negative Pap test and positive high-risk HPV infection among three groups</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Purpose
Comparison of colposcopy-guided biopsy and endocervical cytologic (ECC) results in patients with negative Papanicolaou (Pap) and positive high-risk (HR) HPV tests in the three groups of HPV 16/18, non-16/18 HR-HPV (other HR-HPV), and concurrent infection of either HPV 16/18 and at least one subtype of other HR-HPVs.
Methods
This cross-sectional study was conducted among women aged 30–65 who had negative Pap and positive HR-HPV DNA tests. Pap test was performed using liquid cytology. For HPV DNA testing, the polymerase chain reaction (PCR) method was used.
Results
Among 394 participants, 111 (28.2%) were in the HPV 16/18, 226 (57.4%) in the Other HR-HPV, and 57 (14.4%) in the concurrent group. The mean age of participants was 35.71 ± 7.1 years. Cervical intraepithelial neoplasia (CIN) grade 2/3 were seen in 29 (26.1%) patients of HPV 16/18, 60 (26.5%) of other HR-HPV, and 18 (31.6%) of concurrent infection group (
P
= 0.593). HPV 52 was the most common subtype in the other HR-HPV group (15%).
Conclusions
The risk of high-grade CIN lesions in patients with negative Pap test and positive other HR-HPV was not significantly less than patients with positive HPV 16/18. Besides, the risk of losing the patients to 1-year follow-up seems high.</description><subject>Endocrinology</subject><subject>Gynecologic Oncology</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Human papillomavirus</subject><subject>Infections</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Pap smear</subject><issn>1432-0711</issn><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9UU1v1TAQtBCIlsIf4IAsceESsB3HTo7oCShSJXoArpbjt05cXuxgO0W98dNZ-sqHOHDy7npmdjVDyFPOXnLG9KvCmGSyYUI0TEmJ1T1yymWLreb8_l_1CXlUyhVjXPS9ekhO2k60rVLqlHzfpWW1OZQUafLU3dS02jqnQ5qCoz7EfYhToSFSHAeItdBvoc40woT9NdBLu9IKpVIb93RNJdxO5zDNDap-oeeXn5HtwdWAK-yS4kTrnAHolNO2lsfkgbeHAk_u3jPy6e2bj7vz5uLDu_e71xeNa4WqjXDQjrIbRhgl94J74KrXe6WHVnVMa_BOW1BeKMa97bkbVT8OwyBBjINCI87Ii6PumtPXDQ82SygODgcbIW3FCIWmyH6QHUKf_wO9SluOeJ0RGp0eOq4VosQR5XIqJYM3aw6LzTeGM_MzH3PMx2A-5jYfw5D07E56GxfY_6b8CgQB7RFQ8CtOkP_s_o_sDyPxnDE</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Kasraei, Sara</creator><creator>Ghahghaei-nezamabadi, Akram</creator><creator>Seifollahi, Akram</creator><creator>Aghajani, Faezeh</creator><creator>Nakhostin-Ansari, Amin</creator><creator>Zarei, Neda</creator><creator>Tehranian, Afsaneh</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9119-9593</orcidid><orcidid>https://orcid.org/0000-0002-9019-3904</orcidid><orcidid>https://orcid.org/0000-0001-7090-8426</orcidid><orcidid>https://orcid.org/0000-0002-3594-711X</orcidid><orcidid>https://orcid.org/0000-0002-1113-9257</orcidid><orcidid>https://orcid.org/0000-0002-1198-6886</orcidid><orcidid>https://orcid.org/0000-0003-4356-1038</orcidid></search><sort><creationdate>20220901</creationdate><title>Comparison of cytopathologic findings in patients with negative Pap test and positive high-risk HPV infection among three groups</title><author>Kasraei, Sara ; Ghahghaei-nezamabadi, Akram ; Seifollahi, Akram ; Aghajani, Faezeh ; Nakhostin-Ansari, Amin ; Zarei, Neda ; Tehranian, Afsaneh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-2ce3b459beb41f21fe1687d679365077efc7ae6f2601fa81cb68b9994e2b96143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Endocrinology</topic><topic>Gynecologic Oncology</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Human papillomavirus</topic><topic>Infections</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Pap smear</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kasraei, Sara</creatorcontrib><creatorcontrib>Ghahghaei-nezamabadi, Akram</creatorcontrib><creatorcontrib>Seifollahi, Akram</creatorcontrib><creatorcontrib>Aghajani, Faezeh</creatorcontrib><creatorcontrib>Nakhostin-Ansari, Amin</creatorcontrib><creatorcontrib>Zarei, Neda</creatorcontrib><creatorcontrib>Tehranian, Afsaneh</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kasraei, Sara</au><au>Ghahghaei-nezamabadi, Akram</au><au>Seifollahi, Akram</au><au>Aghajani, Faezeh</au><au>Nakhostin-Ansari, Amin</au><au>Zarei, Neda</au><au>Tehranian, Afsaneh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of cytopathologic findings in patients with negative Pap test and positive high-risk HPV infection among three groups</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2022-09-01</date><risdate>2022</risdate><volume>306</volume><issue>3</issue><spage>857</spage><epage>863</epage><pages>857-863</pages><issn>1432-0711</issn><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Purpose
Comparison of colposcopy-guided biopsy and endocervical cytologic (ECC) results in patients with negative Papanicolaou (Pap) and positive high-risk (HR) HPV tests in the three groups of HPV 16/18, non-16/18 HR-HPV (other HR-HPV), and concurrent infection of either HPV 16/18 and at least one subtype of other HR-HPVs.
Methods
This cross-sectional study was conducted among women aged 30–65 who had negative Pap and positive HR-HPV DNA tests. Pap test was performed using liquid cytology. For HPV DNA testing, the polymerase chain reaction (PCR) method was used.
Results
Among 394 participants, 111 (28.2%) were in the HPV 16/18, 226 (57.4%) in the Other HR-HPV, and 57 (14.4%) in the concurrent group. The mean age of participants was 35.71 ± 7.1 years. Cervical intraepithelial neoplasia (CIN) grade 2/3 were seen in 29 (26.1%) patients of HPV 16/18, 60 (26.5%) of other HR-HPV, and 18 (31.6%) of concurrent infection group (
P
= 0.593). HPV 52 was the most common subtype in the other HR-HPV group (15%).
Conclusions
The risk of high-grade CIN lesions in patients with negative Pap test and positive other HR-HPV was not significantly less than patients with positive HPV 16/18. Besides, the risk of losing the patients to 1-year follow-up seems high.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35233666</pmid><doi>10.1007/s00404-022-06444-0</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-9119-9593</orcidid><orcidid>https://orcid.org/0000-0002-9019-3904</orcidid><orcidid>https://orcid.org/0000-0001-7090-8426</orcidid><orcidid>https://orcid.org/0000-0002-3594-711X</orcidid><orcidid>https://orcid.org/0000-0002-1113-9257</orcidid><orcidid>https://orcid.org/0000-0002-1198-6886</orcidid><orcidid>https://orcid.org/0000-0003-4356-1038</orcidid></addata></record> |
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| ispartof | Archives of gynecology and obstetrics, 2022-09, Vol.306 (3), p.857-863 |
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| language | eng |
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| subjects | Endocrinology Gynecologic Oncology Gynecology Human Genetics Human papillomavirus Infections Medicine Medicine & Public Health Obstetrics/Perinatology/Midwifery Pap smear |
| title | Comparison of cytopathologic findings in patients with negative Pap test and positive high-risk HPV infection among three groups |
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