Hypoxia-stimulated mesenchymal stem cell-derived exosomes loaded by adhesive hydrogel for effective angiogenic treatment of spinal cord injury

Due to the limited efficacy of current clinical treatment strategies, functional recovery after traumatic spinal cord injury (SCI) remains a knotty problem to be solved. Apart from anti-inflammation and cell replenishing treatments, accumulating evidence implies that promoting angiogenesis would als...

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Veröffentlicht in:	Biomaterials science 2022-03, Vol.1 (7), p.183-1811
Hauptverfasser:	Mu, Jiafu, Li, Liming, Wu, Jiahe, Huang, Tianchen, Zhang, Yu, Cao, Jian, Ma, Teng, Chen, Jiachen, Zhang, Chenyang, Zhang, Xunqi, Lu, Tinghao, Kong, Xianglei, Sun, Jihong, Gao, Jianqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesives Angiogenesis Central nervous system Encapsulation Endothelial cells Endothelial Cells - metabolism Exosomes - metabolism Growth factors Health services Humans Hyaluronic acid Hydrogels Hydrogels - metabolism Hypoxia Hypoxia - metabolism Injury prevention Mesenchymal Stem Cells - metabolism Peptides Recovery Regeneration (physiology) Spinal Cord - metabolism Spinal cord injuries Spinal Cord Injuries - drug therapy Spinal Cord Injuries - metabolism Stem cells Tissue engineering Vascular Endothelial Growth Factor A - metabolism
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