Amyloid beta oligomers-induced parkin aggravates ER stress-mediated cell death through a positive feedback loop

Recently, Parkin has been reported to induce endoplasmic reticulum (ER) stress. In addition, amyloid beta oligomers (AβO), hallmarks of Alzheimer's disease (AD), also increase ER stress in neurons. Because a mutation in the Parkin gene is a well-known predominant cause of familial Parkinson...

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Veröffentlicht in:	Neurochemistry international 2022-05, Vol.155, p.105312-105312, Article 105312
Hauptverfasser:	Kam, Min Kyoung, Kim, Bokyung, Lee, Dong Gil, Lee, Hong Jun, Park, Young-Ho, Lee, Dong-Seok
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta oligomers Amyloid beta-Peptides - metabolism Animals ATF4 Cell Death Endoplasmic Reticulum Stress Feedback Mice Mice, Transgenic Parkin Ubiquitin-Protein Ligases - genetics
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