Capsaicin Attenuates Arterial Calcification Through Promoting SIRT6-Mediated Deacetylation and Degradation of Hif1α (Hypoxic-Inducible Factor-1 Alpha)

Sustained Hif1α (hypoxic-inducible factor-1 alpha) accumulation plays a central role in osteogenic transdifferentiation and subsequent calcification. Capsaicin, the potent agonist of TRPV1 (transient receptor potential vanilloid type 1), was found to mitigate hypoxic-related injury and reverse pheno...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2022-05, Vol.79 (5), p.906-917
Hauptverfasser:	Luo, Dongling, Li, Wenxin, Xie, Changming, Yin, Li, Su, Xiaoyan, Chen, Jie, Huang, Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Capsaicin - pharmacology Female Humans Hypoxia Male Mice Myocytes, Smooth Muscle - metabolism Phosphates Renal Insufficiency, Chronic - metabolism Sirtuins - genetics Vascular Calcification - metabolism
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