Activation of Host Immune Cells by Probiotic-Derived Extracellular Vesicles via TLR2-Mediated Signaling Pathways

Since probiotic-derived extracellular vesicles (EVs) are capable of activating innate immunity, they are expected to be useful as novel adjuvants. To elucidate the mechanisms underlying the immunostimulatory effects of EVs released from probiotic cells, we newly investigated the role of Toll-like re...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2022/03/01, Vol.45(3), pp.354-359
Hauptverfasser:	Morishita, Masaki, Sagayama, Risa, Yamawaki, Yuta, Yamaguchi, Marina, Katsumi, Hidemasa, Yamamoto, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Bifidobacterium Cell activation Cytokines extracellular vesicle Extracellular vesicles Immunostimulation Inflammation Innate immunity Interleukin 6 JNK protein Kinases Lactobacillus Macrophages MAP kinase NF-κB protein Peptidoglycans Probiotics proinflammatory cytokine Protein kinase Signal transduction signaling pathway TLR2 protein Toll-like receptor 2 (TLR2) Toll-like receptors Transcription factors Tumor necrosis factor-TNF Tumor necrosis factor-α Zeta potential
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