Pharmacological evaluation of cardioprotective potential of Berberis orthobotrys Bien.ex Aitch
The resurgence of scrutiny in plant-based medicine is mainly due to the current widespread belief that "green medicine" is safe and more dependable than the expensive synthetic drugs. The current study was focused to evaluate the anti-myocardial ischemic potential of Berberis orthobotrys B...
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| Veröffentlicht in: | Pakistan journal of pharmaceutical sciences 2022-01, Vol.35 (1(Supplementary)), p.171-175 |
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| container_issue | 1(Supplementary) |
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| container_title | Pakistan journal of pharmaceutical sciences |
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| creator | Noor, Nabeela Alamgeer, - Irfan, Hafiz Muhammad Akram, Muhammad Arshad, Laiba Alotaibi, Nasser Hadal Alharbi, Khalid Saad Abbas Bukhari, Syed Nasir Althobaiti, Yusuf S Ullah, Aman |
| description | The resurgence of scrutiny in plant-based medicine is mainly due to the current widespread belief that "green medicine" is safe and more dependable than the expensive synthetic drugs. The current study was focused to evaluate the anti-myocardial ischemic potential of Berberis orthobotrys Bien ex Aitch against chemically induced myocardial ischemia in animal models. Myocardial ischemia was instigated in Sprague Dawley rats of either sex (250-450g) by administration of Isoproterenol (ISO) and doxorubicin (DOX) at doses of 25mg/kg b.w and 15mg/kg b.w. respectively. The protective effect of the plant extract was explored by pretreating a group of animals with aqueous methanolic extract of Berberis orthobotrys roots at a dose of 50mg/kg b.w. (orally) for 10 days in ISO-ischemic model while for doxorubicin ischemic model; the study was conducted for 14 days. The findings of the study revealed that serum levels of cardiac marker enzymes were significantly increased (p |
| doi_str_mv | 10.36721/PJPS.2022.35.1.SUP.171-175.1 |
| format | Article |
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The current study was focused to evaluate the anti-myocardial ischemic potential of Berberis orthobotrys Bien ex Aitch against chemically induced myocardial ischemia in animal models. Myocardial ischemia was instigated in Sprague Dawley rats of either sex (250-450g) by administration of Isoproterenol (ISO) and doxorubicin (DOX) at doses of 25mg/kg b.w and 15mg/kg b.w. respectively. The protective effect of the plant extract was explored by pretreating a group of animals with aqueous methanolic extract of Berberis orthobotrys roots at a dose of 50mg/kg b.w. (orally) for 10 days in ISO-ischemic model while for doxorubicin ischemic model; the study was conducted for 14 days. The findings of the study revealed that serum levels of cardiac marker enzymes were significantly increased (p<0.0001) followed by the administration of Isoproterenol and doxorubicin whereas the pretreatment with aqueous methanolic plant extract had significantly (p<0.0001) prevented the rise in the same, as compared to both intoxicated groups. The statistical analysis of the study led to the conclusion that Berberis orthobotrys possesses cardio protective potential against chemically induced myocardial ischemia.</description><identifier>ISSN: 1011-601X</identifier><identifier>DOI: 10.36721/PJPS.2022.35.1.SUP.171-175.1</identifier><identifier>PMID: 35228174</identifier><language>eng</language><publisher>Pakistan</publisher><subject>Animals ; Berberis ; Doxorubicin - toxicity ; Isoproterenol - toxicity ; Myocardial Ischemia - chemically induced ; Myocardial Ischemia - drug therapy ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Pakistan journal of pharmaceutical sciences, 2022-01, Vol.35 (1(Supplementary)), p.171-175</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35228174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Noor, Nabeela</creatorcontrib><creatorcontrib>Alamgeer, -</creatorcontrib><creatorcontrib>Irfan, Hafiz Muhammad</creatorcontrib><creatorcontrib>Akram, Muhammad</creatorcontrib><creatorcontrib>Arshad, Laiba</creatorcontrib><creatorcontrib>Alotaibi, Nasser Hadal</creatorcontrib><creatorcontrib>Alharbi, Khalid Saad</creatorcontrib><creatorcontrib>Abbas Bukhari, Syed Nasir</creatorcontrib><creatorcontrib>Althobaiti, Yusuf S</creatorcontrib><creatorcontrib>Ullah, Aman</creatorcontrib><title>Pharmacological evaluation of cardioprotective potential of Berberis orthobotrys Bien.ex Aitch</title><title>Pakistan journal of pharmaceutical sciences</title><addtitle>Pak J Pharm Sci</addtitle><description>The resurgence of scrutiny in plant-based medicine is mainly due to the current widespread belief that "green medicine" is safe and more dependable than the expensive synthetic drugs. The current study was focused to evaluate the anti-myocardial ischemic potential of Berberis orthobotrys Bien ex Aitch against chemically induced myocardial ischemia in animal models. Myocardial ischemia was instigated in Sprague Dawley rats of either sex (250-450g) by administration of Isoproterenol (ISO) and doxorubicin (DOX) at doses of 25mg/kg b.w and 15mg/kg b.w. respectively. The protective effect of the plant extract was explored by pretreating a group of animals with aqueous methanolic extract of Berberis orthobotrys roots at a dose of 50mg/kg b.w. (orally) for 10 days in ISO-ischemic model while for doxorubicin ischemic model; the study was conducted for 14 days. The findings of the study revealed that serum levels of cardiac marker enzymes were significantly increased (p<0.0001) followed by the administration of Isoproterenol and doxorubicin whereas the pretreatment with aqueous methanolic plant extract had significantly (p<0.0001) prevented the rise in the same, as compared to both intoxicated groups. The statistical analysis of the study led to the conclusion that Berberis orthobotrys possesses cardio protective potential against chemically induced myocardial ischemia.</description><subject>Animals</subject><subject>Berberis</subject><subject>Doxorubicin - toxicity</subject><subject>Isoproterenol - toxicity</subject><subject>Myocardial Ischemia - chemically induced</subject><subject>Myocardial Ischemia - drug therapy</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kF9LwzAUxfOguDn9CtIXwZfW3KRNmsdt-JeBhTnwyZKmqYu0zUzS4b69FefLufdwfxwuB6FrwAllnMBt8VysE4IJSWiWQLLeFAlwiIGP7gRNAQPEDMPbBJ17_4kxS4UQZ2hCM0Jy4OkUvRdb6TqpbGs_jJJtpPeyHWQwto9sEynpamN3zgatgtnraDdufTAjOF4X2lXaGR9ZF7a2ssEdfLQwuk_0dzQ3QW0v0GkjW68vj3OGNvd3r8vHePXy8LScr-IdEBZiKYTK8gzSmqhG0FEqzhkFLUVO65xqRphuFE2F4gBNzmnFiMJ1VrGsqTGlM3Tzlzu--jVoH8rOeKXbVvbaDr4kjKZjPqe_6NURHapO1-XOmU66Q_nfCf0B4s1mKA</recordid><startdate>202201</startdate><enddate>202201</enddate><creator>Noor, Nabeela</creator><creator>Alamgeer, -</creator><creator>Irfan, Hafiz Muhammad</creator><creator>Akram, Muhammad</creator><creator>Arshad, Laiba</creator><creator>Alotaibi, Nasser Hadal</creator><creator>Alharbi, Khalid Saad</creator><creator>Abbas Bukhari, Syed Nasir</creator><creator>Althobaiti, Yusuf S</creator><creator>Ullah, Aman</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>202201</creationdate><title>Pharmacological evaluation of cardioprotective potential of Berberis orthobotrys Bien.ex Aitch</title><author>Noor, Nabeela ; Alamgeer, - ; Irfan, Hafiz Muhammad ; Akram, Muhammad ; Arshad, Laiba ; Alotaibi, Nasser Hadal ; Alharbi, Khalid Saad ; Abbas Bukhari, Syed Nasir ; Althobaiti, Yusuf S ; Ullah, Aman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-a99c58514d2cf932cfb77631ea983d83e626efc349c711f873b62c0d5b65fd033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Berberis</topic><topic>Doxorubicin - toxicity</topic><topic>Isoproterenol - toxicity</topic><topic>Myocardial Ischemia - chemically induced</topic><topic>Myocardial Ischemia - drug therapy</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Noor, Nabeela</creatorcontrib><creatorcontrib>Alamgeer, -</creatorcontrib><creatorcontrib>Irfan, Hafiz Muhammad</creatorcontrib><creatorcontrib>Akram, Muhammad</creatorcontrib><creatorcontrib>Arshad, Laiba</creatorcontrib><creatorcontrib>Alotaibi, Nasser Hadal</creatorcontrib><creatorcontrib>Alharbi, Khalid Saad</creatorcontrib><creatorcontrib>Abbas Bukhari, Syed Nasir</creatorcontrib><creatorcontrib>Althobaiti, Yusuf S</creatorcontrib><creatorcontrib>Ullah, Aman</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Noor, Nabeela</au><au>Alamgeer, -</au><au>Irfan, Hafiz Muhammad</au><au>Akram, Muhammad</au><au>Arshad, Laiba</au><au>Alotaibi, Nasser Hadal</au><au>Alharbi, Khalid Saad</au><au>Abbas Bukhari, Syed Nasir</au><au>Althobaiti, Yusuf S</au><au>Ullah, Aman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacological evaluation of cardioprotective potential of Berberis orthobotrys Bien.ex Aitch</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><addtitle>Pak J Pharm Sci</addtitle><date>2022-01</date><risdate>2022</risdate><volume>35</volume><issue>1(Supplementary)</issue><spage>171</spage><epage>175</epage><pages>171-175</pages><issn>1011-601X</issn><abstract>The resurgence of scrutiny in plant-based medicine is mainly due to the current widespread belief that "green medicine" is safe and more dependable than the expensive synthetic drugs. The current study was focused to evaluate the anti-myocardial ischemic potential of Berberis orthobotrys Bien ex Aitch against chemically induced myocardial ischemia in animal models. Myocardial ischemia was instigated in Sprague Dawley rats of either sex (250-450g) by administration of Isoproterenol (ISO) and doxorubicin (DOX) at doses of 25mg/kg b.w and 15mg/kg b.w. respectively. The protective effect of the plant extract was explored by pretreating a group of animals with aqueous methanolic extract of Berberis orthobotrys roots at a dose of 50mg/kg b.w. (orally) for 10 days in ISO-ischemic model while for doxorubicin ischemic model; the study was conducted for 14 days. The findings of the study revealed that serum levels of cardiac marker enzymes were significantly increased (p<0.0001) followed by the administration of Isoproterenol and doxorubicin whereas the pretreatment with aqueous methanolic plant extract had significantly (p<0.0001) prevented the rise in the same, as compared to both intoxicated groups. The statistical analysis of the study led to the conclusion that Berberis orthobotrys possesses cardio protective potential against chemically induced myocardial ischemia.</abstract><cop>Pakistan</cop><pmid>35228174</pmid><doi>10.36721/PJPS.2022.35.1.SUP.171-175.1</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Berberis Doxorubicin - toxicity Isoproterenol - toxicity Myocardial Ischemia - chemically induced Myocardial Ischemia - drug therapy Plant Extracts - chemistry Plant Extracts - pharmacology Rats Rats, Sprague-Dawley |
| title | Pharmacological evaluation of cardioprotective potential of Berberis orthobotrys Bien.ex Aitch |
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