Occupational lead exposure is an independent modulator of hypertension and poor pulmonary function: A cross-sectional comparative study in lead-acid battery recycling workers
Blood lead level (BLL) is the primary biomarker for lead-exposure monitoring in occupationally exposed workers. We evaluated occupational lead-exposure (OE) impact on cardiopulmonary functions in lead-acid battery recycling unit workers. Seventy-six OE cases and 30 control subjects were enrolled for...
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| Veröffentlicht in: | Toxicology and industrial health 2022-03, Vol.38 (3), p.139-150 |
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| creator | Yadav, Shiv K Patil, Gajanan P Virmagami, Ankit Bijalwan, Vandana Devi, Kirti Chauhan, Aakriti Gupta, Sanjeev K Fathima, Shabarin Naorem, Chaoba D Yadav, Suresh Singh, Gyanendra Mishra, SukhDev Bishnoi, Mahendra Sarkar, Kamalesh Singh, Dhirendra P |
| description | Blood lead level (BLL) is the primary biomarker for lead-exposure monitoring in occupationally exposed workers. We evaluated occupational lead-exposure (OE) impact on cardiopulmonary functions in lead-acid battery recycling unit workers. Seventy-six OE cases and 30 control subjects were enrolled for questionnaire-based socio-demographic, dietary, tobacco usage, and medical history data. Anthropometric measurements, systolic and diastolic blood pressure (SBP and DBP), and pulmonary function tests were performed. Venous blood was collected for BLL, hematological analysis, and biochemical analysis. OE caused a significant increase in BLL, SBP, DBP, and small airways obstruction in lung function tests. It also impaired platelet indices, affected renal and liver biochemical measurements, and promoted oxidative stress and DNA damage. Multilinear regression analysis suggested that BLL affected SBP (β = 0.314, p = .034) and increased small airways obstruction (FEV1/FVC, β = −0.37, p = .05; FEV25–75%, β = −0.351, p = .016). Higher BLL appears to be an independent modulator of hypertension and poor pulmonary function upon occupational lead exposure in lead-acid battery recyclers. |
| doi_str_mv | 10.1177/07482337221076248 |
| format | Article |
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We evaluated occupational lead-exposure (OE) impact on cardiopulmonary functions in lead-acid battery recycling unit workers. Seventy-six OE cases and 30 control subjects were enrolled for questionnaire-based socio-demographic, dietary, tobacco usage, and medical history data. Anthropometric measurements, systolic and diastolic blood pressure (SBP and DBP), and pulmonary function tests were performed. Venous blood was collected for BLL, hematological analysis, and biochemical analysis. OE caused a significant increase in BLL, SBP, DBP, and small airways obstruction in lung function tests. It also impaired platelet indices, affected renal and liver biochemical measurements, and promoted oxidative stress and DNA damage. Multilinear regression analysis suggested that BLL affected SBP (β = 0.314, p = .034) and increased small airways obstruction (FEV1/FVC, β = −0.37, p = .05; FEV25–75%, β = −0.351, p = .016). Higher BLL appears to be an independent modulator of hypertension and poor pulmonary function upon occupational lead exposure in lead-acid battery recyclers.</description><identifier>ISSN: 0748-2337</identifier><identifier>EISSN: 1477-0393</identifier><identifier>DOI: 10.1177/07482337221076248</identifier><identifier>PMID: 35230206</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Biochemical analysis ; Biomarkers ; Blood levels ; Blood pressure ; Blood Pressure - physiology ; Comparative studies ; Cross-Sectional Studies ; DNA damage ; Exposure ; Humans ; Hypertension ; Hypertension - etiology ; Lead ; Lead acid batteries ; Lead poisoning ; Occupational exposure ; Occupational Exposure - adverse effects ; Occupational Exposure - analysis ; Oxidative stress ; Pulmonary functions ; Regression analysis ; Respiratory function ; Tobacco</subject><ispartof>Toxicology and industrial health, 2022-03, Vol.38 (3), p.139-150</ispartof><rights>The Author(s) 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c283t-8578299dcc2188e7cb1da75809415dddcffda43b0a4d557c8871eff044a9ff9e3</citedby><cites>FETCH-LOGICAL-c283t-8578299dcc2188e7cb1da75809415dddcffda43b0a4d557c8871eff044a9ff9e3</cites><orcidid>0000-0002-9193-0849 ; 0000-0002-9454-9752</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/07482337221076248$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/07482337221076248$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35230206$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yadav, Shiv K</creatorcontrib><creatorcontrib>Patil, Gajanan P</creatorcontrib><creatorcontrib>Virmagami, Ankit</creatorcontrib><creatorcontrib>Bijalwan, Vandana</creatorcontrib><creatorcontrib>Devi, Kirti</creatorcontrib><creatorcontrib>Chauhan, Aakriti</creatorcontrib><creatorcontrib>Gupta, Sanjeev K</creatorcontrib><creatorcontrib>Fathima, Shabarin</creatorcontrib><creatorcontrib>Naorem, Chaoba D</creatorcontrib><creatorcontrib>Yadav, Suresh</creatorcontrib><creatorcontrib>Singh, Gyanendra</creatorcontrib><creatorcontrib>Mishra, SukhDev</creatorcontrib><creatorcontrib>Bishnoi, Mahendra</creatorcontrib><creatorcontrib>Sarkar, Kamalesh</creatorcontrib><creatorcontrib>Singh, Dhirendra P</creatorcontrib><title>Occupational lead exposure is an independent modulator of hypertension and poor pulmonary function: A cross-sectional comparative study in lead-acid battery recycling workers</title><title>Toxicology and industrial health</title><addtitle>Toxicol Ind Health</addtitle><description>Blood lead level (BLL) is the primary biomarker for lead-exposure monitoring in occupationally exposed workers. We evaluated occupational lead-exposure (OE) impact on cardiopulmonary functions in lead-acid battery recycling unit workers. Seventy-six OE cases and 30 control subjects were enrolled for questionnaire-based socio-demographic, dietary, tobacco usage, and medical history data. Anthropometric measurements, systolic and diastolic blood pressure (SBP and DBP), and pulmonary function tests were performed. Venous blood was collected for BLL, hematological analysis, and biochemical analysis. OE caused a significant increase in BLL, SBP, DBP, and small airways obstruction in lung function tests. It also impaired platelet indices, affected renal and liver biochemical measurements, and promoted oxidative stress and DNA damage. Multilinear regression analysis suggested that BLL affected SBP (β = 0.314, p = .034) and increased small airways obstruction (FEV1/FVC, β = −0.37, p = .05; FEV25–75%, β = −0.351, p = .016). Higher BLL appears to be an independent modulator of hypertension and poor pulmonary function upon occupational lead exposure in lead-acid battery recyclers.</description><subject>Biochemical analysis</subject><subject>Biomarkers</subject><subject>Blood levels</subject><subject>Blood pressure</subject><subject>Blood Pressure - physiology</subject><subject>Comparative studies</subject><subject>Cross-Sectional Studies</subject><subject>DNA damage</subject><subject>Exposure</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - etiology</subject><subject>Lead</subject><subject>Lead acid batteries</subject><subject>Lead poisoning</subject><subject>Occupational exposure</subject><subject>Occupational Exposure - adverse effects</subject><subject>Occupational Exposure - analysis</subject><subject>Oxidative stress</subject><subject>Pulmonary functions</subject><subject>Regression analysis</subject><subject>Respiratory function</subject><subject>Tobacco</subject><issn>0748-2337</issn><issn>1477-0393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAUhS0EokPhAdggS2y6SfFv7LCrKv6kSt2068hjX5eUJDZ2DMxL9RlxOgNIrdjYi_udc3TvQeg1JaeUKvWOKKEZ54oxSlTLhH6CNlQo1RDe8ados86bFThCL3K-JYS0rWTP0RGXjBNG2g26u7S2RLMMYTYjHsE4DL9iyCUBHjI2Mx5mBxHqMy94Cq6MZgkJB4-_7iKkBeZctRV0OIY6iGWcqlfaYV9mu_q-x2fYppBzk8EegmyYokk19gfgvBS3qzH36Y2xg8NbsyxQLRLYnR2H-Qb_DOkbpPwSPfNmzPDq8B-j648frs4_NxeXn76cn100lmm-NFoqzbrOWcuo1qDsljqjpCadoNI5Z713RvAtMcJJqazWioL3RAjTed8BP0Yne9-YwvcCeemnIVsYRzNDKLlnLRdaUkJVRd8-QG9DSXXJlRKMCamUqBTdU_eXSOD7mIapnqmnpF_L7B-VWTVvDs5lO4H7q_jTXgVO90A2N_Av9v-OvwEskKt9</recordid><startdate>202203</startdate><enddate>202203</enddate><creator>Yadav, Shiv K</creator><creator>Patil, Gajanan P</creator><creator>Virmagami, Ankit</creator><creator>Bijalwan, Vandana</creator><creator>Devi, Kirti</creator><creator>Chauhan, Aakriti</creator><creator>Gupta, Sanjeev K</creator><creator>Fathima, Shabarin</creator><creator>Naorem, Chaoba D</creator><creator>Yadav, Suresh</creator><creator>Singh, Gyanendra</creator><creator>Mishra, SukhDev</creator><creator>Bishnoi, Mahendra</creator><creator>Sarkar, Kamalesh</creator><creator>Singh, Dhirendra P</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T2</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7U7</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9193-0849</orcidid><orcidid>https://orcid.org/0000-0002-9454-9752</orcidid></search><sort><creationdate>202203</creationdate><title>Occupational lead exposure is an independent modulator of hypertension and poor pulmonary function: A cross-sectional comparative study in lead-acid battery recycling workers</title><author>Yadav, Shiv K ; Patil, Gajanan P ; Virmagami, Ankit ; Bijalwan, Vandana ; Devi, Kirti ; Chauhan, Aakriti ; Gupta, Sanjeev K ; Fathima, Shabarin ; Naorem, Chaoba D ; Yadav, Suresh ; Singh, Gyanendra ; Mishra, SukhDev ; Bishnoi, Mahendra ; Sarkar, Kamalesh ; Singh, Dhirendra P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c283t-8578299dcc2188e7cb1da75809415dddcffda43b0a4d557c8871eff044a9ff9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biochemical analysis</topic><topic>Biomarkers</topic><topic>Blood levels</topic><topic>Blood pressure</topic><topic>Blood Pressure - 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We evaluated occupational lead-exposure (OE) impact on cardiopulmonary functions in lead-acid battery recycling unit workers. Seventy-six OE cases and 30 control subjects were enrolled for questionnaire-based socio-demographic, dietary, tobacco usage, and medical history data. Anthropometric measurements, systolic and diastolic blood pressure (SBP and DBP), and pulmonary function tests were performed. Venous blood was collected for BLL, hematological analysis, and biochemical analysis. OE caused a significant increase in BLL, SBP, DBP, and small airways obstruction in lung function tests. It also impaired platelet indices, affected renal and liver biochemical measurements, and promoted oxidative stress and DNA damage. Multilinear regression analysis suggested that BLL affected SBP (β = 0.314, p = .034) and increased small airways obstruction (FEV1/FVC, β = −0.37, p = .05; FEV25–75%, β = −0.351, p = .016). 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| subjects | Biochemical analysis Biomarkers Blood levels Blood pressure Blood Pressure - physiology Comparative studies Cross-Sectional Studies DNA damage Exposure Humans Hypertension Hypertension - etiology Lead Lead acid batteries Lead poisoning Occupational exposure Occupational Exposure - adverse effects Occupational Exposure - analysis Oxidative stress Pulmonary functions Regression analysis Respiratory function Tobacco |
| title | Occupational lead exposure is an independent modulator of hypertension and poor pulmonary function: A cross-sectional comparative study in lead-acid battery recycling workers |
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