Sustained Exosome‐Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and MiRNAs, and Sustained Release Formulation

Macrophages (Mφs) are characterized by remarkable plasticity, an essential component of chronic inflammation. Thus, an appropriate and timely transition from proinflammatory (M1) to anti‐inflammatory (M2) Mφs during wound healing is vital to promoting resolution of acute inflammation and enhancing t...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2022-04, Vol.18 (15), p.e2200060-n/a
Hauptverfasser:	Kwak, Gijung, Cheng, Jing, Kim, Hyosuk, Song, Sukyung, Lee, Su Jin, Yang, Yoosoo, Jeong, Ji Hoon, Lee, Ji Eun, Messersmith, Phillip B., Kim, Sun Hwa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocompatible Materials - metabolism Controlled release Crosslinking cutaneous wound healing Degradation Delayed-Action Preparations exosomal miRNA sequencing exosome proteomics Exosomes - metabolism exosome‐guided cell reprogramming Homeostasis Hydrogels Inflammation - metabolism Macrophages Macrophages - metabolism macrophage‐derived exosomes MicroRNAs - metabolism Nanotechnology Polarization Polyethylene glycol Repair Sustained release Tightness Wound healing Wound Healing - physiology
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