Synthesis, photochemistry and computational study of novel 1,2,3-triazole heterostilbenes: Expressed biological activity of their electrocyclization photoproducts

[Display omitted] •Novel triazolostilbenes photochemically transformed to naphthotriazoles in high yields.•Heterostilbenes and naphthotriazoles inhibited AChE and TNFα production in LPS-stimulated PBMCs.•Computationally assessed insight into structure of complexes with AChE. New 1,2,3-triazolostilbe...

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Veröffentlicht in:	Bioorganic chemistry 2022-04, Vol.121, p.105701-105701, Article 105701
Hauptverfasser:	Mlakić, Milena, Faraho, Ivan, Odak, Ilijana, Talić, Stanislava, Vukovinski, Ana, Raspudić, Anamarija, Bosnar, Martina, Zadravec, Rahela, Ratković, Ana, Lasić, Kornelija, Marinić, Željko, Barić, Danijela, Škorić, Irena
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Anti-inflammatory activity Butyrylcholinesterase - metabolism Cholinesterase inhibition Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Density functional theory Docking Molecular Docking Simulation Photochemistry Structure-Activity Relationship Triazoles - pharmacology
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