Discovery of dual-target ligands binding to beta2-adrenoceptor and cysteinyl-leukotriene receptor for the potential treatment of asthma from natural products derived DNA-encoded library

The design, synthesis, and discovery of dual-target compounds are considered as a promising strategy to develop new drugs with improved safety and efficacy compared with single-target drugs. This necessitates development of the methodologies that enable us to rapidly and accurately achieve the dual-...

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Veröffentlicht in:	European journal of medicinal chemistry 2022-04, Vol.233, p.114212-114212, Article 114212
Hauptverfasser:	Liang, Qi, Zuo, Haiyue, Yang, Tian, Yin, Jiatai, Huang, Xiaomin, Wang, Jing, Li, Qian, Yin, Guowei, Zhao, Xinfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Asthma Asthma - drug therapy Biological Products Cysteine DNA-Encoded library Drug discovery Leukotrienes Ligands Mice Natural products Receptor chromatography Receptors, Leukotriene - genetics Receptors, Leukotriene - metabolism Signal Transduction
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