Silica nanoparticles induce pyroptosis and cardiac hypertrophy via ROS/NLRP3/Caspase-1 pathway

Growing literatures suggest that silica nanoparticles (SiNPs) exposure is correlated with adverse cardiovascular effects. Cardiac hypertrophy is one of the most common risk factors for heart failure. However, whether SiNPs involved in cardiac hypertrophy and the underlying mechanisms was remained un...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Free radical biology & medicine 2022-03, Vol.182, p.171-181
Hauptverfasser:	Wang, Fenghong, Liang, Qingqing, Ma, Yuexiao, Sun, Mengqi, Li, Tianyu, Lin, Lisen, Sun, Zhiwei, Duan, Junchao
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiac hypertrophy Cardiomegaly - chemically induced Caspase 1 - genetics Caspase 1 - metabolism Humans Inflammasomes - metabolism Inflammation Nanoparticles NLR Family, Pyrin Domain-Containing 3 Protein - genetics NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Pyroptosis Reactive Oxygen Species - metabolism ROS/NLRP3/Caspase-1 pathway Silica nanoparticles Silicon Dioxide - toxicity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!