Long-term kidney and systemic effects of calorie restriction in overweight or obese type 2 diabetic patients (C.Re.S.O. 2 randomized controlled trial)
•In patients with T2D and obesity, calorie restriction ameliorated hyperfiltration.•This effect translated into a relative long-term stabilization of kidney function.•In this population calorie restriction improved many cardiovascular risk factors. In type 2 diabetic patients with obesity, hyperfilt...
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| Veröffentlicht in: | Diabetes research and clinical practice 2022-03, Vol.185, p.109804-109804, Article 109804 |
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| creator | Ruggenenti, Piero Cortinovis, Monica Trillini, Matias Parvanova, Aneliya Abbate, Manuela Satriano, Chiara Salvetti, Ferdinando Bossi, Antonio C. Trevisan, Roberto Perna, Annalisa Peracchi, Tobia Rubis, Nadia Diadei, Olimpia Martinetti, Davide Gaspari, Flavio Fontana, Luigi Remuzzi, Giuseppe |
| description | •In patients with T2D and obesity, calorie restriction ameliorated hyperfiltration.•This effect translated into a relative long-term stabilization of kidney function.•In this population calorie restriction improved many cardiovascular risk factors.
In type 2 diabetic patients with obesity, hyperfiltration is a risk factor for accelerated glomerular filtration rate (GFR) decline and is ameliorated by calorie restriction (CR). We assessed whether CR-induced amelioration of hyperfiltration could translate into slower long-term GFR decline in this population.
In this academic, single-center, parallel-group, prospective, randomized, open-label, blinded endpoint trial, consenting >40-year-old patients with type 2 diabetes, BMI ≥27 kg/m2, creatinine |
| doi_str_mv | 10.1016/j.diabres.2022.109804 |
| format | Article |
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In type 2 diabetic patients with obesity, hyperfiltration is a risk factor for accelerated glomerular filtration rate (GFR) decline and is ameliorated by calorie restriction (CR). We assessed whether CR-induced amelioration of hyperfiltration could translate into slower long-term GFR decline in this population.
In this academic, single-center, parallel-group, prospective, randomized, open-label, blinded endpoint trial, consenting >40-year-old patients with type 2 diabetes, BMI ≥27 kg/m2, creatinine <1.2 mg/dL and albuminuria ≤300 mg/24 h were randomized (1:1) to two-year 25% CR (n = 53) or standard diet (SD, n = 50). Primary outcome was 6-month measured GFR. Analyses were by modified intention-to-treat.
At 6 months GFR decreased by 5.16 ± 10.03 mL/min (P = 0.001) with CR, and by 0.98 ± 9.71 mL/min (P = 0.497) with SD. Between-group difference was significant (P = 0.044). GFR decline from 6 to 24 months was significant with SD (P < 0.01), but not with CR (P = 0.075). Between-group difference, however, was not significant (P = 0.414). Body weight, BMI, waist circumference, systolic blood pressure, HbA1c, blood glucose, serum triglycerides decreased and ApoA-I concentration increased with CR. No changes were observed with SD. Between-group differences were significant. CR was tolerated well.
In obese type 2 diabetic patients, CR ameliorated glomerular hyperfiltration and several cardiovascular risk factors, and blunted long-term GFR decline.
Trial registration: NCT01930136.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/j.diabres.2022.109804</identifier><identifier>PMID: 35219762</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Adult ; Albuminuria - complications ; Caloric Restriction ; Calorie restriction ; Cardiovascular risk ; Diabetes Mellitus, Type 2 - complications ; Diabetic Nephropathies - etiology ; Female ; Glomerular Filtration Rate - physiology ; Humans ; Kidney ; Male ; Nephropathy ; Obesity ; Obesity - complications ; Overweight - complications ; Prospective Studies ; Type 2 diabetes</subject><ispartof>Diabetes research and clinical practice, 2022-03, Vol.185, p.109804-109804, Article 109804</ispartof><rights>2022 The Authors</rights><rights>Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-81575c1b5ff1be0b21ce63a6424a4412a5477f19d98b55ae19b36ab7c373efe93</citedby><cites>FETCH-LOGICAL-c412t-81575c1b5ff1be0b21ce63a6424a4412a5477f19d98b55ae19b36ab7c373efe93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.diabres.2022.109804$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35219762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruggenenti, Piero</creatorcontrib><creatorcontrib>Cortinovis, Monica</creatorcontrib><creatorcontrib>Trillini, Matias</creatorcontrib><creatorcontrib>Parvanova, Aneliya</creatorcontrib><creatorcontrib>Abbate, Manuela</creatorcontrib><creatorcontrib>Satriano, Chiara</creatorcontrib><creatorcontrib>Salvetti, Ferdinando</creatorcontrib><creatorcontrib>Bossi, Antonio C.</creatorcontrib><creatorcontrib>Trevisan, Roberto</creatorcontrib><creatorcontrib>Perna, Annalisa</creatorcontrib><creatorcontrib>Peracchi, Tobia</creatorcontrib><creatorcontrib>Rubis, Nadia</creatorcontrib><creatorcontrib>Diadei, Olimpia</creatorcontrib><creatorcontrib>Martinetti, Davide</creatorcontrib><creatorcontrib>Gaspari, Flavio</creatorcontrib><creatorcontrib>Fontana, Luigi</creatorcontrib><creatorcontrib>Remuzzi, Giuseppe</creatorcontrib><creatorcontrib>Organization</creatorcontrib><creatorcontrib>on behalf of the CRESO 2 Study</creatorcontrib><creatorcontrib>CRESO 2 Study</creatorcontrib><title>Long-term kidney and systemic effects of calorie restriction in overweight or obese type 2 diabetic patients (C.Re.S.O. 2 randomized controlled trial)</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>•In patients with T2D and obesity, calorie restriction ameliorated hyperfiltration.•This effect translated into a relative long-term stabilization of kidney function.•In this population calorie restriction improved many cardiovascular risk factors.
In type 2 diabetic patients with obesity, hyperfiltration is a risk factor for accelerated glomerular filtration rate (GFR) decline and is ameliorated by calorie restriction (CR). We assessed whether CR-induced amelioration of hyperfiltration could translate into slower long-term GFR decline in this population.
In this academic, single-center, parallel-group, prospective, randomized, open-label, blinded endpoint trial, consenting >40-year-old patients with type 2 diabetes, BMI ≥27 kg/m2, creatinine <1.2 mg/dL and albuminuria ≤300 mg/24 h were randomized (1:1) to two-year 25% CR (n = 53) or standard diet (SD, n = 50). Primary outcome was 6-month measured GFR. Analyses were by modified intention-to-treat.
At 6 months GFR decreased by 5.16 ± 10.03 mL/min (P = 0.001) with CR, and by 0.98 ± 9.71 mL/min (P = 0.497) with SD. Between-group difference was significant (P = 0.044). GFR decline from 6 to 24 months was significant with SD (P < 0.01), but not with CR (P = 0.075). Between-group difference, however, was not significant (P = 0.414). Body weight, BMI, waist circumference, systolic blood pressure, HbA1c, blood glucose, serum triglycerides decreased and ApoA-I concentration increased with CR. No changes were observed with SD. Between-group differences were significant. CR was tolerated well.
In obese type 2 diabetic patients, CR ameliorated glomerular hyperfiltration and several cardiovascular risk factors, and blunted long-term GFR decline.
Trial registration: NCT01930136.</description><subject>Adult</subject><subject>Albuminuria - complications</subject><subject>Caloric Restriction</subject><subject>Calorie restriction</subject><subject>Cardiovascular risk</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetic Nephropathies - etiology</subject><subject>Female</subject><subject>Glomerular Filtration Rate - physiology</subject><subject>Humans</subject><subject>Kidney</subject><subject>Male</subject><subject>Nephropathy</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Overweight - complications</subject><subject>Prospective Studies</subject><subject>Type 2 diabetes</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9uEzEQxi0EomnhEah8bA-72N71_jlVKGopUqRKLZwt2zsuTnfXqe0UhQfheZmQwJWTR_Zvvs8zHyEfOCs5483HdTl4bSKkUjAh8K7vWP2KLHjXiqITon1NFsh1f-oTcprSmjHWVLV8S04qKXjfNmJBfq3C_FhkiBN98sMMO6rngaZdyjB5S8E5sDnR4KjVY4geKFrm6G32YaZ-puEF4g_wj98zDZEGAwlo3m2ACrr_IGRU2ejsYUaZi2V5D-VDeVfic0SnMPmfMFAb5hzDOGKJ2nq8fEfeOD0meH88z8i3m-uvy9tidff5y_LTqrA1F7nouGyl5UY6xw0wI7iFptJNLWpdI6Fl3baO90PfGSk18N5UjTatrdoKHPTVGbk46G5ieN7iZGryycI46hnCNimxX5hAukFUHlAbQ0oRnNpEP-m4U5ypfSRqrY6RqH0k6hAJ9p0fLbZmguFf198MELg6AICDvniIKllcl4XBR1y-GoL_j8VvGD6gqQ</recordid><startdate>202203</startdate><enddate>202203</enddate><creator>Ruggenenti, Piero</creator><creator>Cortinovis, Monica</creator><creator>Trillini, Matias</creator><creator>Parvanova, Aneliya</creator><creator>Abbate, Manuela</creator><creator>Satriano, Chiara</creator><creator>Salvetti, Ferdinando</creator><creator>Bossi, Antonio C.</creator><creator>Trevisan, Roberto</creator><creator>Perna, Annalisa</creator><creator>Peracchi, Tobia</creator><creator>Rubis, Nadia</creator><creator>Diadei, Olimpia</creator><creator>Martinetti, Davide</creator><creator>Gaspari, Flavio</creator><creator>Fontana, Luigi</creator><creator>Remuzzi, Giuseppe</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202203</creationdate><title>Long-term kidney and systemic effects of calorie restriction in overweight or obese type 2 diabetic patients (C.Re.S.O. 2 randomized controlled trial)</title><author>Ruggenenti, Piero ; 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In type 2 diabetic patients with obesity, hyperfiltration is a risk factor for accelerated glomerular filtration rate (GFR) decline and is ameliorated by calorie restriction (CR). We assessed whether CR-induced amelioration of hyperfiltration could translate into slower long-term GFR decline in this population.
In this academic, single-center, parallel-group, prospective, randomized, open-label, blinded endpoint trial, consenting >40-year-old patients with type 2 diabetes, BMI ≥27 kg/m2, creatinine <1.2 mg/dL and albuminuria ≤300 mg/24 h were randomized (1:1) to two-year 25% CR (n = 53) or standard diet (SD, n = 50). Primary outcome was 6-month measured GFR. Analyses were by modified intention-to-treat.
At 6 months GFR decreased by 5.16 ± 10.03 mL/min (P = 0.001) with CR, and by 0.98 ± 9.71 mL/min (P = 0.497) with SD. Between-group difference was significant (P = 0.044). GFR decline from 6 to 24 months was significant with SD (P < 0.01), but not with CR (P = 0.075). Between-group difference, however, was not significant (P = 0.414). Body weight, BMI, waist circumference, systolic blood pressure, HbA1c, blood glucose, serum triglycerides decreased and ApoA-I concentration increased with CR. No changes were observed with SD. Between-group differences were significant. CR was tolerated well.
In obese type 2 diabetic patients, CR ameliorated glomerular hyperfiltration and several cardiovascular risk factors, and blunted long-term GFR decline.
Trial registration: NCT01930136.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>35219762</pmid><doi>10.1016/j.diabres.2022.109804</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Diabetes research and clinical practice, 2022-03, Vol.185, p.109804-109804, Article 109804 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Albuminuria - complications Caloric Restriction Calorie restriction Cardiovascular risk Diabetes Mellitus, Type 2 - complications Diabetic Nephropathies - etiology Female Glomerular Filtration Rate - physiology Humans Kidney Male Nephropathy Obesity Obesity - complications Overweight - complications Prospective Studies Type 2 diabetes |
| title | Long-term kidney and systemic effects of calorie restriction in overweight or obese type 2 diabetic patients (C.Re.S.O. 2 randomized controlled trial) |
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