lncRNA TUG1 protects intestinal epithelial cells from damage induced by high glucose and high fat via AMPK/SIRT1

he incidence of obesity and type 2 diabetes mellitus (T2DM) is increasing year by year and shows a trend towards younger age groups worldwide. It has become a disease that endangers the health of individuals all over the world. Among numerous weight loss surgeries, sleeve gastrectomy (SG) has become...

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Veröffentlicht in:	Molecular medicine reports 2022-04, Vol.25 (4), Article 139
Hauptverfasser:	Wei, Weiwei, Wang, Xingquan, Wei, Yaqing, Liu, Shilin, Gao, Shengyu, Tian, Hao, Su, Dewang
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-activated protein kinase AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Apoptosis Apoptosis - genetics Bcl-2 protein Biotechnology Body weight loss Breast cancer Cell culture Cell growth Cell viability Colorectal cancer Dextrose Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Epithelial cells Epithelial Cells - metabolism Estrogens Fat Flow cytometry Gastrectomy Gastrointestinal surgery Gene expression Genetic aspects Glucose Glucose - metabolism Health aspects Humans IL-1β Interleukin 10 Interleukin 6 Interleukin 8 Intestine Intestines Laboratories Lung cancer Male Metabolism MicroRNAs - genetics Mitochondrial uncoupling protein 2 Non-coding RNA Obesity Physiological aspects Protein kinases Reverse transcription RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism SIRT1 protein Sirtuin 1 - genetics Sirtuin 1 - metabolism Taurine Taurine - metabolism Tumors Weight control Western blotting
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