Inhibition of mitochondrial fission protects podocytes from albumin-induced cell damage in diabetic kidney disease

Identifying the mechanisms that underlie progression from endothelial damage to podocyte damage, which leads to massive proteinuria, is an urgent issue that must be clarified to improve renal outcome in diabetic kidney disease (DKD). We aimed to examine the role of dynamin-related protein 1 (Drp1)-m...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2022-05, Vol.1868 (5), p.166368-166368, Article 166368
Hauptverfasser:	Tagaya, Makoto, Kume, Shinji, Yasuda-Yamahara, Mako, Kuwagata, Shogo, Yamahara, Kosuke, Takeda, Naoko, Tanaka, Yuki, Chin-Kanasaki, Masami, Nakae, Yuki, Yokoi, Hideki, Mukoyama, Masashi, Ishihara, Naotada, Nomura, Masatoshi, Araki, Shin-ichi, Maegawa, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumins - metabolism Albumins - pharmacology Albuminuria Albuminuria - genetics Albuminuria - metabolism Animals Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetic kidney disease Diabetic Nephropathies - pathology Drp1 Female Humans Male Mice Mitochondrial Dynamics Mitochondrial fission Neuraminidase - metabolism Podocyte Podocytes - metabolism Proteinuria - metabolism Proteinuria - pathology
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