Impact of metabolic syndrome and systemic inflammation on endothelial function in postmenopausal women
Data on the impact of metabolic syndrome (MetS) and systemic inflammation on endothelial function remains scarce. In this study, we aimed to investigate the combined effects of MetS and systemic inflammation on endothelial function in postmenopausal women. We identified 423 postmenopausal women from...
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| Veröffentlicht in: | Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology 2022-01, Vol.50 (1), p.57-85 |
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| container_title | Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology |
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| creator | Zhang, Hongju Sun, Tao Cheng, Yutong Zhang, Jing Zhang, HaiXia Krittanawong, Chayakrit El-Am, Edward Karam, Roukoz Abou Wang, Su Wang, Qian Ma, Ning |
| description | Data on the impact of metabolic syndrome (MetS) and systemic inflammation on endothelial function remains scarce. In this study, we aimed to investigate the combined effects of MetS and systemic inflammation on endothelial function in postmenopausal women.
We identified 423 postmenopausal women from February 2019 through July 2020. MetS was diagnosed according to the International Diabetes Federation (IDF) criteria, and high sensitivity C-reaction protein (hs-CRP) was measured to assess the degree of underlying inflammation. The measurement of endothelial function was using digital arterial tonometry by assessing reactive hyperemia-induced vasodilation in one arm and adjusting for changes in the contralateral arm (reactive hyperemia index, RHI).
There were 156 patients with MetS and 267 without MetS. Compared to the group without MetS, patients with MetS had significantly lower natural logarithmic RHI (0.66±0.29 versus 0.91±0.31; p |
| doi_str_mv | 10.5543/tkda.2022.47443 |
| format | Article |
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We identified 423 postmenopausal women from February 2019 through July 2020. MetS was diagnosed according to the International Diabetes Federation (IDF) criteria, and high sensitivity C-reaction protein (hs-CRP) was measured to assess the degree of underlying inflammation. The measurement of endothelial function was using digital arterial tonometry by assessing reactive hyperemia-induced vasodilation in one arm and adjusting for changes in the contralateral arm (reactive hyperemia index, RHI).
There were 156 patients with MetS and 267 without MetS. Compared to the group without MetS, patients with MetS had significantly lower natural logarithmic RHI (0.66±0.29 versus 0.91±0.31; p<0.001), but higher levels of hs-CRP (0.98 [0.31, 3.54] versus 0.53 [0.20, 2.14]; p<0.001). In sequential multivariable analysis, the presence of hs-CRP (ΔR2=0.047, p=0.004) had a significant and independent influence on natural logarithmic RHI. Furthermore, the interaction of hs-CRP*MetS was synergistically associated with endothelial dysfunction even in the fully adjusted model (β=-0.107, 95% CI [-0.161~-0.053], p=0.009).
MetS and systemic inflammation are synergistically associated with endothelial dysfunction in postmenopausal women. Postmenopausal women with both these conditions appear to be at a significantly higher risk for adverse cardiovascular events.</description><identifier>ISSN: 1016-5169</identifier><identifier>EISSN: 1308-4488</identifier><identifier>DOI: 10.5543/tkda.2022.47443</identifier><identifier>PMID: 35197234</identifier><language>eng</language><publisher>Turkey: Aves Yayincilik Ltd. STI</publisher><subject>C-Reactive Protein - metabolism ; Female ; Health risks ; Humans ; Inflammation - complications ; Menopause ; Metabolic syndrome ; Metabolic Syndrome - complications ; Metabolic Syndrome - epidemiology ; Postmenopause ; Risk Factors ; Womens health</subject><ispartof>Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology, 2022-01, Vol.50 (1), p.57-85</ispartof><rights>2022. This work is published under https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35197234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Hongju</creatorcontrib><creatorcontrib>Sun, Tao</creatorcontrib><creatorcontrib>Cheng, Yutong</creatorcontrib><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Zhang, HaiXia</creatorcontrib><creatorcontrib>Krittanawong, Chayakrit</creatorcontrib><creatorcontrib>El-Am, Edward</creatorcontrib><creatorcontrib>Karam, Roukoz Abou</creatorcontrib><creatorcontrib>Wang, Su</creatorcontrib><creatorcontrib>Wang, Qian</creatorcontrib><creatorcontrib>Ma, Ning</creatorcontrib><creatorcontrib>Department of Echocardiography, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China</creatorcontrib><creatorcontrib>Section of Cardiology, Baylor College of Medicine, Houston, TX, USA</creatorcontrib><creatorcontrib>Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China</creatorcontrib><creatorcontrib>Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA</creatorcontrib><creatorcontrib>Department of Echocardiography, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health</creatorcontrib><creatorcontrib>Department of Ultrasound, Shunyi Maternal and Children’s Hospital of Beijng Children’s Hospital, Beijing, China</creatorcontrib><creatorcontrib>The Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center Harvard Medical School, Boston Massachusetts, USA</creatorcontrib><title>Impact of metabolic syndrome and systemic inflammation on endothelial function in postmenopausal women</title><title>Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology</title><addtitle>Turk Kardiyol Dern Ars</addtitle><description>Data on the impact of metabolic syndrome (MetS) and systemic inflammation on endothelial function remains scarce. In this study, we aimed to investigate the combined effects of MetS and systemic inflammation on endothelial function in postmenopausal women.
We identified 423 postmenopausal women from February 2019 through July 2020. MetS was diagnosed according to the International Diabetes Federation (IDF) criteria, and high sensitivity C-reaction protein (hs-CRP) was measured to assess the degree of underlying inflammation. The measurement of endothelial function was using digital arterial tonometry by assessing reactive hyperemia-induced vasodilation in one arm and adjusting for changes in the contralateral arm (reactive hyperemia index, RHI).
There were 156 patients with MetS and 267 without MetS. Compared to the group without MetS, patients with MetS had significantly lower natural logarithmic RHI (0.66±0.29 versus 0.91±0.31; p<0.001), but higher levels of hs-CRP (0.98 [0.31, 3.54] versus 0.53 [0.20, 2.14]; p<0.001). In sequential multivariable analysis, the presence of hs-CRP (ΔR2=0.047, p=0.004) had a significant and independent influence on natural logarithmic RHI. Furthermore, the interaction of hs-CRP*MetS was synergistically associated with endothelial dysfunction even in the fully adjusted model (β=-0.107, 95% CI [-0.161~-0.053], p=0.009).
MetS and systemic inflammation are synergistically associated with endothelial dysfunction in postmenopausal women. Postmenopausal women with both these conditions appear to be at a significantly higher risk for adverse cardiovascular events.</description><subject>C-Reactive Protein - metabolism</subject><subject>Female</subject><subject>Health risks</subject><subject>Humans</subject><subject>Inflammation - complications</subject><subject>Menopause</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - complications</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Postmenopause</subject><subject>Risk Factors</subject><subject>Womens health</subject><issn>1016-5169</issn><issn>1308-4488</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkUtLxTAQhYMoKnrX7qTgxk3vzatpsxTxBYIbXZc8JlhtktqkiP_eXF8LITDJmS-HYQ5CJwSvm4azTX61ak0xpWvecs520CFhuKs577rdcsdE1A0R8gCtUho05rwVjEu8jw5YQ2RLGT9E7s5PyuQquspDVjqOg6nSR7Bz9FCpYMsjZfBFHYIblfcqDzFU5UCwMT_DOKixckswX_oQqimm7CHESS2ptN6LUThGe06NCVY_9Qg9XV89Xt7W9w83d5cX97VhFOcaAMtWNMaKhjjWgjVaGEs747htO2CdbqlhWisMpJPcKOe0FI4YCY5rzNgROv_2neb4tkDKvR-SgXFUAeKSeioY7bCUsi3o2T_0JS5zKNMVqmko5oLyQm2-KTPHlGZw_TQPXs0fPcH9NoV-m0K_TaH_SqH8OP3xXbQH-8f_7px9Aq1Jhbk</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Zhang, Hongju</creator><creator>Sun, Tao</creator><creator>Cheng, Yutong</creator><creator>Zhang, Jing</creator><creator>Zhang, HaiXia</creator><creator>Krittanawong, Chayakrit</creator><creator>El-Am, Edward</creator><creator>Karam, Roukoz Abou</creator><creator>Wang, Su</creator><creator>Wang, Qian</creator><creator>Ma, Ning</creator><general>Aves Yayincilik Ltd. STI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20220101</creationdate><title>Impact of metabolic syndrome and systemic inflammation on endothelial function in postmenopausal women</title><author>Zhang, Hongju ; Sun, Tao ; Cheng, Yutong ; Zhang, Jing ; Zhang, HaiXia ; Krittanawong, Chayakrit ; El-Am, Edward ; Karam, Roukoz Abou ; Wang, Su ; Wang, Qian ; Ma, Ning</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c320t-ee09765cd651f37edcb6cd28cf4d78e38b72c3bba0e1894caffb96f1c9ef4b033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>C-Reactive Protein - metabolism</topic><topic>Female</topic><topic>Health risks</topic><topic>Humans</topic><topic>Inflammation - complications</topic><topic>Menopause</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - complications</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Postmenopause</topic><topic>Risk Factors</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Hongju</creatorcontrib><creatorcontrib>Sun, Tao</creatorcontrib><creatorcontrib>Cheng, Yutong</creatorcontrib><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Zhang, HaiXia</creatorcontrib><creatorcontrib>Krittanawong, Chayakrit</creatorcontrib><creatorcontrib>El-Am, Edward</creatorcontrib><creatorcontrib>Karam, Roukoz Abou</creatorcontrib><creatorcontrib>Wang, Su</creatorcontrib><creatorcontrib>Wang, Qian</creatorcontrib><creatorcontrib>Ma, Ning</creatorcontrib><creatorcontrib>Department of Echocardiography, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China</creatorcontrib><creatorcontrib>Section of Cardiology, Baylor College of Medicine, Houston, TX, USA</creatorcontrib><creatorcontrib>Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China</creatorcontrib><creatorcontrib>Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA</creatorcontrib><creatorcontrib>Department of Echocardiography, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health</creatorcontrib><creatorcontrib>Department of Ultrasound, Shunyi Maternal and Children’s Hospital of Beijng Children’s Hospital, Beijing, China</creatorcontrib><creatorcontrib>The Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center Harvard Medical School, Boston Massachusetts, USA</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Hongju</au><au>Sun, Tao</au><au>Cheng, Yutong</au><au>Zhang, Jing</au><au>Zhang, HaiXia</au><au>Krittanawong, Chayakrit</au><au>El-Am, Edward</au><au>Karam, Roukoz Abou</au><au>Wang, Su</au><au>Wang, Qian</au><au>Ma, Ning</au><aucorp>Department of Echocardiography, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China</aucorp><aucorp>Section of Cardiology, Baylor College of Medicine, Houston, TX, USA</aucorp><aucorp>Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China</aucorp><aucorp>Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA</aucorp><aucorp>Department of Echocardiography, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health</aucorp><aucorp>Department of Ultrasound, Shunyi Maternal and Children’s Hospital of Beijng Children’s Hospital, Beijing, China</aucorp><aucorp>The Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center Harvard Medical School, Boston Massachusetts, USA</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of metabolic syndrome and systemic inflammation on endothelial function in postmenopausal women</atitle><jtitle>Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology</jtitle><addtitle>Turk Kardiyol Dern Ars</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>50</volume><issue>1</issue><spage>57</spage><epage>85</epage><pages>57-85</pages><issn>1016-5169</issn><eissn>1308-4488</eissn><abstract>Data on the impact of metabolic syndrome (MetS) and systemic inflammation on endothelial function remains scarce. In this study, we aimed to investigate the combined effects of MetS and systemic inflammation on endothelial function in postmenopausal women.
We identified 423 postmenopausal women from February 2019 through July 2020. MetS was diagnosed according to the International Diabetes Federation (IDF) criteria, and high sensitivity C-reaction protein (hs-CRP) was measured to assess the degree of underlying inflammation. The measurement of endothelial function was using digital arterial tonometry by assessing reactive hyperemia-induced vasodilation in one arm and adjusting for changes in the contralateral arm (reactive hyperemia index, RHI).
There were 156 patients with MetS and 267 without MetS. Compared to the group without MetS, patients with MetS had significantly lower natural logarithmic RHI (0.66±0.29 versus 0.91±0.31; p<0.001), but higher levels of hs-CRP (0.98 [0.31, 3.54] versus 0.53 [0.20, 2.14]; p<0.001). In sequential multivariable analysis, the presence of hs-CRP (ΔR2=0.047, p=0.004) had a significant and independent influence on natural logarithmic RHI. Furthermore, the interaction of hs-CRP*MetS was synergistically associated with endothelial dysfunction even in the fully adjusted model (β=-0.107, 95% CI [-0.161~-0.053], p=0.009).
MetS and systemic inflammation are synergistically associated with endothelial dysfunction in postmenopausal women. Postmenopausal women with both these conditions appear to be at a significantly higher risk for adverse cardiovascular events.</abstract><cop>Turkey</cop><pub>Aves Yayincilik Ltd. STI</pub><pmid>35197234</pmid><doi>10.5543/tkda.2022.47443</doi><tpages>29</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology, 2022-01, Vol.50 (1), p.57-85 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | C-Reactive Protein - metabolism Female Health risks Humans Inflammation - complications Menopause Metabolic syndrome Metabolic Syndrome - complications Metabolic Syndrome - epidemiology Postmenopause Risk Factors Womens health |
| title | Impact of metabolic syndrome and systemic inflammation on endothelial function in postmenopausal women |
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