Synthesis of spiroindolenine-3,3'-pyrrolo[2,1- b ]quinazolinones through gold(I)-catalyzed dearomative cyclization of N -alkynyl quinazolinone-tethered indoles
A variety of functionalized spiroindolenine-3,3'-pyrrolo[2,1- ]quinazolinones were prepared in good to excellent yields through a gold(I)-catalyzed dearomative cyclization of -alkynyl quinazolinone-tethered C2-substituted indoles. This reaction features a broad substrate scope, good functional...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2022-03, Vol.20 (10), p.2069-2074 |
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| container_issue | 10 |
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| container_title | Organic & biomolecular chemistry |
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| creator | Wang, Wang Zou, Pei-Sen Pang, Li Lei, Yao Huang, Zi-Yi Chen, Nan-Ying Mo, Dong-Liang Pan, Cheng-Xue Su, Gui-Fa |
| description | A variety of functionalized spiroindolenine-3,3'-pyrrolo[2,1-
]quinazolinones were prepared in good to excellent yields through a gold(I)-catalyzed dearomative cyclization of
-alkynyl quinazolinone-tethered C2-substituted indoles. This reaction features a broad substrate scope, good functional group tolerance, and easy gram-scale preparation and transformations. Furthermore, biological activity studies showed that most of the obtained spiroindolenine-3,3'-pyrrolo[2,1-
]quinazolinone scaffolds showed potential as good anti-inflammatory agents. |
| doi_str_mv | 10.1039/d1ob02492b |
| format | Article |
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]quinazolinones were prepared in good to excellent yields through a gold(I)-catalyzed dearomative cyclization of
-alkynyl quinazolinone-tethered C2-substituted indoles. This reaction features a broad substrate scope, good functional group tolerance, and easy gram-scale preparation and transformations. Furthermore, biological activity studies showed that most of the obtained spiroindolenine-3,3'-pyrrolo[2,1-
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-alkynyl quinazolinone-tethered C2-substituted indoles. This reaction features a broad substrate scope, good functional group tolerance, and easy gram-scale preparation and transformations. Furthermore, biological activity studies showed that most of the obtained spiroindolenine-3,3'-pyrrolo[2,1-
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-alkynyl quinazolinone-tethered C2-substituted indoles. This reaction features a broad substrate scope, good functional group tolerance, and easy gram-scale preparation and transformations. Furthermore, biological activity studies showed that most of the obtained spiroindolenine-3,3'-pyrrolo[2,1-
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| ispartof | Organic & biomolecular chemistry, 2022-03, Vol.20 (10), p.2069-2074 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_2632805281 |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Anti-inflammatory agents Biological activity Functional groups Gold Indoles Inflammation Quinazolinone Quinazolinones Substrates |
| title | Synthesis of spiroindolenine-3,3'-pyrrolo[2,1- b ]quinazolinones through gold(I)-catalyzed dearomative cyclization of N -alkynyl quinazolinone-tethered indoles |
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