The lung microbiome regulates brain autoimmunity

Lung infections and smoking are risk factors for multiple sclerosis, a T-cell-mediated autoimmune disease of the central nervous system 1 . In addition, the lung serves as a niche for the disease-inducing T cells for long-term survival and for maturation into migration-competent effector T cells 2 ....

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Veröffentlicht in:	Nature (London) 2022-03, Vol.603 (7899), p.138-144
Hauptverfasser:	Hosang, Leon, Canals, Roger Cugota, van der Flier, Felicia Joy, Hollensteiner, Jacqueline, Daniel, Rolf, Flügel, Alexander, Odoardi, Francesca
Format:	Artikel
Sprache:	eng
Schlagworte:	13 14 14/19 14/69 38 38/77 38/91 631/250/371 631/250/38 64 Animals Antibiotics Autoimmune Diseases Autoimmunity Brain - physiology Cell adhesion molecules Cell division Confocal microscopy Digestive system Endothelium Experimental allergic encephalomyelitis Gastrointestinal system Gastrointestinal tract Humanities and Social Sciences Immunization Influence Intestinal microflora Lipopolysaccharides - pharmacology Lung - microbiology Lymphocytes Meninges Microbiomes Microbiota multidisciplinary Multiple Sclerosis - etiology Neomycin Nervous system Rats Scanning microscopy Science Science (multidisciplinary) Spinal cord Trachea Transcription
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