The regulatory role of autophagy-related miRNAs in lung cancer drug resistance
Autophagy is conserved cellular machinery that degrades un-usable proteins and cellular components and has a crucial role in the pathogenesis and drug resistance of various diseases such as lung cancer (LC). Multiple types of endogenous molecules (i.e. miRNAs) have been found to regulate multiple bi...
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| Veröffentlicht in: | Biomedicine & pharmacotherapy 2022-04, Vol.148, p.112735-112735, Article 112735 |
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| creator | Shahverdi, Mahshid Hajiasgharzadeh, Khalil Sorkhabi, Amin Daei Jafarlou, Mahdi Shojaee, Maryam Jalili Tabrizi, Neda Alizadeh, Nazila Santarpia, Mariacarmela Brunetti, Oronzo Safarpour, Hossein Silvestris, Nicola Baradaran, Behzad |
| description | Autophagy is conserved cellular machinery that degrades un-usable proteins and cellular components and has a crucial role in the pathogenesis and drug resistance of various diseases such as lung cancer (LC). Multiple types of endogenous molecules (i.e. miRNAs) have been found to regulate multiple biological processes, such as autophagy. Dysfunction of these molecules is associated with the onset and progression of a variety of human malignancies. Several studies had shown that some miRNAs could mediate autophagy activity in LC cells, which would affect drug resistance as a major problem in LC therapy. Therefore, identifying the underlying molecular targets of miRNAs and their function in autophagy pathways could develop new treatment interventions for LC patients. In this review, we will summarize the interplay between miRNAs, autophagy, and drug resistance of LC patients, as well as the genes and molecular pathways that are involved. |
| doi_str_mv | 10.1016/j.biopha.2022.112735 |
| format | Article |
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Multiple types of endogenous molecules (i.e. miRNAs) have been found to regulate multiple biological processes, such as autophagy. Dysfunction of these molecules is associated with the onset and progression of a variety of human malignancies. Several studies had shown that some miRNAs could mediate autophagy activity in LC cells, which would affect drug resistance as a major problem in LC therapy. Therefore, identifying the underlying molecular targets of miRNAs and their function in autophagy pathways could develop new treatment interventions for LC patients. In this review, we will summarize the interplay between miRNAs, autophagy, and drug resistance of LC patients, as well as the genes and molecular pathways that are involved.</description><identifier>ISSN: 0753-3322</identifier><identifier>EISSN: 1950-6007</identifier><identifier>DOI: 10.1016/j.biopha.2022.112735</identifier><identifier>PMID: 35193040</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Autophagy ; Autophagy - genetics ; Cell Proliferation - genetics ; Drug resistance ; Drug Resistance, Neoplasm - genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Lung cancer ; Lung Neoplasms - drug therapy ; Lung Neoplasms - genetics ; Lung Neoplasms - metabolism ; MicroRNAs - genetics ; MicroRNAs - metabolism ; MiRNA ; Signal Transduction - genetics</subject><ispartof>Biomedicine & pharmacotherapy, 2022-04, Vol.148, p.112735-112735, Article 112735</ispartof><rights>2022 The Authors</rights><rights>Copyright © 2022 The Authors. 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In this review, we will summarize the interplay between miRNAs, autophagy, and drug resistance of LC patients, as well as the genes and molecular pathways that are involved.</description><subject>Autophagy</subject><subject>Autophagy - genetics</subject><subject>Cell Proliferation - genetics</subject><subject>Drug resistance</subject><subject>Drug Resistance, Neoplasm - genetics</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - metabolism</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>MiRNA</subject><subject>Signal Transduction - genetics</subject><issn>0753-3322</issn><issn>1950-6007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMobk7_gUguvek8SZo2vRHG8AvGBJnXIU1Pt4xunUkr7N_b0umlVwfOeT84DyG3DKYMWPKwneauPmzMlAPnU8Z4KuQZGbNMQpQApOdkDKkUkRCcj8hVCFsAkIlQl2QkJMsExDAmy9UGqcd1W5mm9kfq6wppXVLTNn34-hh57E5Y0J37WM4CdXtatfs1tWZv0dPCt-vOH1xo-sU1uShNFfDmNCfk8_lpNX-NFu8vb_PZIrIxqCbiNkkNE0whi5UyKmVcCpUbnkqAmGexStJYGClzk2eqtFiCUAkyMCorubViQu6H3IOvv1oMjd65YLGqzB7rNmieCM4k6zB00niQWl-H4LHUB-92xh81A92T1Fs9kNQ9ST2Q7Gx3p4Y232HxZ_pF1wkeBwF2f3479DpYhx2Dwnm0jS5q93_DD6NChM8</recordid><startdate>202204</startdate><enddate>202204</enddate><creator>Shahverdi, Mahshid</creator><creator>Hajiasgharzadeh, Khalil</creator><creator>Sorkhabi, Amin Daei</creator><creator>Jafarlou, Mahdi</creator><creator>Shojaee, Maryam</creator><creator>Jalili Tabrizi, Neda</creator><creator>Alizadeh, Nazila</creator><creator>Santarpia, Mariacarmela</creator><creator>Brunetti, Oronzo</creator><creator>Safarpour, Hossein</creator><creator>Silvestris, Nicola</creator><creator>Baradaran, Behzad</creator><general>Elsevier Masson SAS</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202204</creationdate><title>The regulatory role of autophagy-related miRNAs in lung cancer drug resistance</title><author>Shahverdi, Mahshid ; 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| subjects | Autophagy Autophagy - genetics Cell Proliferation - genetics Drug resistance Drug Resistance, Neoplasm - genetics Gene Expression Regulation, Neoplastic Humans Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - metabolism MicroRNAs - genetics MicroRNAs - metabolism MiRNA Signal Transduction - genetics |
| title | The regulatory role of autophagy-related miRNAs in lung cancer drug resistance |
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