Integration of Toxicogenomics and Physiologically Based Pharmacokinetic Modeling in Human Health Risk Assessment of Perfluorooctane Sulfonate

Toxicogenomics and physiologically based pharmacokinetic (PBPK) models are useful approaches in chemical risk assessment, but the methodology to incorporate toxicogenomic data into a PBPK model to inform risk assessment remains to be developed. This study aimed to develop a probabilistic human healt...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Environmental science & technology 2022-03, Vol.56 (6), p.3623-3633
Hauptverfasser:	Chen, Qiran, Chou, Wei-Chun, Lin, Zhoumeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkanesulfonic Acids - toxicity Animals Bayes Theorem Bayesian analysis Biocompatibility Ecotoxicology and Public Health Encyclopedias Environmental protection Fluorocarbons Genes Genomes Health risk assessment Health risks Humans In vivo methods and tests Mathematical models Mice Modelling Models, Biological Perfluorooctane sulfonic acid Pharmacokinetics Pharmacology Response data analysis Risk Assessment Sulfonates Toxicity Toxicogenetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!