Yeast β-glucan Increases Etoposide Sensitivity in Lung Cancer Cell Line A549 by Suppressing Nuclear Factor Erythroid 2-Related Factor 2 via the Noncanonical Nuclear Factor Kappa B Pathway

Etoposide is regarded as one of the main standard cytotoxic drugs for lung cancer. However, mutations in Kelch-like ECH-associated protein 1 (Keap1), the main regulator of nuclear factor erythroid 2-related factor 2 (Nrf2), are often detected in lung cancer and lead to chemoresistance. Since the abe...

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Veröffentlicht in:	Molecular pharmacology 2022-04, Vol.101 (4), p.257-273
Hauptverfasser:	Siswanto, Ferbian Milas, Tamura, Akiyoshi, Sakuma, Rika, Imaoka, Susumu
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells beta-Glucans - pharmacology Cullin Proteins - metabolism Etoposide - pharmacology Humans Kelch-Like ECH-Associated Protein 1 - genetics Lung Neoplasms - drug therapy NF-E2-Related Factor 2 - metabolism NF-kappa B - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Saccharomyces cerevisiae - metabolism
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