Contribution of glycemic variability to hypoglycemia, and a new marker for diabetes remission after Roux-en-Y gastric bypass surgery
Diabetes remission after bariatric surgery was reported to be characterized by increased risk of hypoglycemia. This study aimed to examine the contribution of glycemic variability (GV) to the risk of hypoglycemia, and the suitability of time in range (TIR), an emerging glycemic marker, to define dia...
Gespeichert in:
| Veröffentlicht in: | Surgery for obesity and related diseases 2022-05, Vol.18 (5), p.666-673 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 673 |
|---|---|
| container_issue | 5 |
| container_start_page | 666 |
| container_title | Surgery for obesity and related diseases |
| container_volume | 18 |
| creator | Lu, Jingyi Pan, Yunhui Tu, Yinfang Zhang, Pin Zhou, Jian Yu, Haoyong |
| description | Diabetes remission after bariatric surgery was reported to be characterized by increased risk of hypoglycemia.
This study aimed to examine the contribution of glycemic variability (GV) to the risk of hypoglycemia, and the suitability of time in range (TIR), an emerging glycemic marker, to define diabetes remission after Roux-en-Y gastric bypass (RYGB).
A single referral center in China.
This retrospective study included 175 individuals with type 2 diabetes and obesity who underwent RYGB. Subjects were classified as remission/nonremission according to the current standard. Each participant underwent continuous glucose monitoring both before and 1 year after RYGB. GV was measured by glucose coefficient of variation (CV), and hypoglycemia was assessed by time below range (TBR).
Complete remission was achieved in 88 of the 175 participants following RYGB. In the remission group, significant correlations between postoperative CV and TBRs (r = .353–.442, both P ≤ .001) were found. Excess hypoglycemia (TBR |
| doi_str_mv | 10.1016/j.soard.2022.01.012 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2631866227</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1550728922000284</els_id><sourcerecordid>2631866227</sourcerecordid><originalsourceid>FETCH-LOGICAL-c359t-6f4c1aee0035c41f0b8eb60930596e2175ddd2124d25a596817dd9733de68e7a3</originalsourceid><addsrcrecordid>eNp9kEtPGzEUha0KVB7tL6hUecmiE_yI7ZlFFyiigISEhOiiK8tj30mdTsap7aHMnh-OQ1KWSFey5fvde3wOQl8omVFC5flqloKJbsYIYzNCS7EP6JjWqq6U4Pyg3IUglWJ1c4ROUloRwqVQ7CM64oI2hMnmGD0vwpCjb8fsw4BDh5f9ZGHtLX400ZvW9z5POAf8e9qEfc98w2Zw2OAB_uG1iX8g4i5E7AoPGRKOBUppu9B0uTTvw_hUwVD9wkuTiprF7bQxKeE0xiXE6RM67Eyf4PP-PEU_f1w-LK6r27urm8XFbWW5aHIlu7mlBqD4EHZOO9LW0ErScCIaCYwq4ZxjlM0dE6Y81VQ51yjOHcgalOGn6Gy3dxPD3xFS1uWfFvreDBDGpJnktJaSMVVQvkNtDClF6PQm-uJ10pTobfx6pV_j19v4NaGlWJn6uhcY2zW4t5n_eRfg-w6AYvPRQ9TJehgsOB_BZu2Cf1fgBZYmmWw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2631866227</pqid></control><display><type>article</type><title>Contribution of glycemic variability to hypoglycemia, and a new marker for diabetes remission after Roux-en-Y gastric bypass surgery</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Lu, Jingyi ; Pan, Yunhui ; Tu, Yinfang ; Zhang, Pin ; Zhou, Jian ; Yu, Haoyong</creator><creatorcontrib>Lu, Jingyi ; Pan, Yunhui ; Tu, Yinfang ; Zhang, Pin ; Zhou, Jian ; Yu, Haoyong</creatorcontrib><description>Diabetes remission after bariatric surgery was reported to be characterized by increased risk of hypoglycemia.
This study aimed to examine the contribution of glycemic variability (GV) to the risk of hypoglycemia, and the suitability of time in range (TIR), an emerging glycemic marker, to define diabetes remission after Roux-en-Y gastric bypass (RYGB).
A single referral center in China.
This retrospective study included 175 individuals with type 2 diabetes and obesity who underwent RYGB. Subjects were classified as remission/nonremission according to the current standard. Each participant underwent continuous glucose monitoring both before and 1 year after RYGB. GV was measured by glucose coefficient of variation (CV), and hypoglycemia was assessed by time below range (TBR).
Complete remission was achieved in 88 of the 175 participants following RYGB. In the remission group, significant correlations between postoperative CV and TBRs (r = .353–.442, both P ≤ .001) were found. Excess hypoglycemia (TBR<54 , ≥1%, TBR<70, ≥4%) increased with ascending CV quintiles (both P for trend <.05) and was significantly more frequent in subjects with glucose CV >32.2% (both P <.05). Compared with glycated hemoglobin A1C, TIR showed stronger correlation with glucose CV and risk of hypoglycemia.
Increased glycemic variability was linked to excess risk of hypoglycemia after RYGB. Furthermore, TIR may serve as a new metric, in addition to HbA1C, for defining diabetes remission.
1.Glycemic variability (GV) assessed by glucose coefficient of variation (CV) was significantly linked to hypoglycemia in patients following Roux-en-Y gastric bypass surgery (RYGB).2.A new glycemic metric, time in range (TIR), showed stronger relationship to GV and hypoglycemia as compared with A1c, and may be a promising marker for defining diabetes remission after bariatric surgery.</description><identifier>ISSN: 1550-7289</identifier><identifier>EISSN: 1878-7533</identifier><identifier>DOI: 10.1016/j.soard.2022.01.012</identifier><identifier>PMID: 35190269</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Bariatric surgery ; Biomarkers ; Blood Glucose ; Blood Glucose Self-Monitoring - adverse effects ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - surgery ; Diabetes remission ; Gastric Bypass - adverse effects ; Glycemic variability ; Humans ; Hypoglycemia ; Hypoglycemia - etiology ; Retrospective Studies</subject><ispartof>Surgery for obesity and related diseases, 2022-05, Vol.18 (5), p.666-673</ispartof><rights>2022</rights><rights>Copyright © 2022. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-6f4c1aee0035c41f0b8eb60930596e2175ddd2124d25a596817dd9733de68e7a3</citedby><cites>FETCH-LOGICAL-c359t-6f4c1aee0035c41f0b8eb60930596e2175ddd2124d25a596817dd9733de68e7a3</cites><orcidid>0000-0002-8621-4960 ; 0000-0003-1105-4189</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1550728922000284$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35190269$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Jingyi</creatorcontrib><creatorcontrib>Pan, Yunhui</creatorcontrib><creatorcontrib>Tu, Yinfang</creatorcontrib><creatorcontrib>Zhang, Pin</creatorcontrib><creatorcontrib>Zhou, Jian</creatorcontrib><creatorcontrib>Yu, Haoyong</creatorcontrib><title>Contribution of glycemic variability to hypoglycemia, and a new marker for diabetes remission after Roux-en-Y gastric bypass surgery</title><title>Surgery for obesity and related diseases</title><addtitle>Surg Obes Relat Dis</addtitle><description>Diabetes remission after bariatric surgery was reported to be characterized by increased risk of hypoglycemia.
This study aimed to examine the contribution of glycemic variability (GV) to the risk of hypoglycemia, and the suitability of time in range (TIR), an emerging glycemic marker, to define diabetes remission after Roux-en-Y gastric bypass (RYGB).
A single referral center in China.
This retrospective study included 175 individuals with type 2 diabetes and obesity who underwent RYGB. Subjects were classified as remission/nonremission according to the current standard. Each participant underwent continuous glucose monitoring both before and 1 year after RYGB. GV was measured by glucose coefficient of variation (CV), and hypoglycemia was assessed by time below range (TBR).
Complete remission was achieved in 88 of the 175 participants following RYGB. In the remission group, significant correlations between postoperative CV and TBRs (r = .353–.442, both P ≤ .001) were found. Excess hypoglycemia (TBR<54 , ≥1%, TBR<70, ≥4%) increased with ascending CV quintiles (both P for trend <.05) and was significantly more frequent in subjects with glucose CV >32.2% (both P <.05). Compared with glycated hemoglobin A1C, TIR showed stronger correlation with glucose CV and risk of hypoglycemia.
Increased glycemic variability was linked to excess risk of hypoglycemia after RYGB. Furthermore, TIR may serve as a new metric, in addition to HbA1C, for defining diabetes remission.
1.Glycemic variability (GV) assessed by glucose coefficient of variation (CV) was significantly linked to hypoglycemia in patients following Roux-en-Y gastric bypass surgery (RYGB).2.A new glycemic metric, time in range (TIR), showed stronger relationship to GV and hypoglycemia as compared with A1c, and may be a promising marker for defining diabetes remission after bariatric surgery.</description><subject>Bariatric surgery</subject><subject>Biomarkers</subject><subject>Blood Glucose</subject><subject>Blood Glucose Self-Monitoring - adverse effects</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - surgery</subject><subject>Diabetes remission</subject><subject>Gastric Bypass - adverse effects</subject><subject>Glycemic variability</subject><subject>Humans</subject><subject>Hypoglycemia</subject><subject>Hypoglycemia - etiology</subject><subject>Retrospective Studies</subject><issn>1550-7289</issn><issn>1878-7533</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPGzEUha0KVB7tL6hUecmiE_yI7ZlFFyiigISEhOiiK8tj30mdTsap7aHMnh-OQ1KWSFey5fvde3wOQl8omVFC5flqloKJbsYIYzNCS7EP6JjWqq6U4Pyg3IUglWJ1c4ROUloRwqVQ7CM64oI2hMnmGD0vwpCjb8fsw4BDh5f9ZGHtLX400ZvW9z5POAf8e9qEfc98w2Zw2OAB_uG1iX8g4i5E7AoPGRKOBUppu9B0uTTvw_hUwVD9wkuTiprF7bQxKeE0xiXE6RM67Eyf4PP-PEU_f1w-LK6r27urm8XFbWW5aHIlu7mlBqD4EHZOO9LW0ErScCIaCYwq4ZxjlM0dE6Y81VQ51yjOHcgalOGn6Gy3dxPD3xFS1uWfFvreDBDGpJnktJaSMVVQvkNtDClF6PQm-uJ10pTobfx6pV_j19v4NaGlWJn6uhcY2zW4t5n_eRfg-w6AYvPRQ9TJehgsOB_BZu2Cf1fgBZYmmWw</recordid><startdate>202205</startdate><enddate>202205</enddate><creator>Lu, Jingyi</creator><creator>Pan, Yunhui</creator><creator>Tu, Yinfang</creator><creator>Zhang, Pin</creator><creator>Zhou, Jian</creator><creator>Yu, Haoyong</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8621-4960</orcidid><orcidid>https://orcid.org/0000-0003-1105-4189</orcidid></search><sort><creationdate>202205</creationdate><title>Contribution of glycemic variability to hypoglycemia, and a new marker for diabetes remission after Roux-en-Y gastric bypass surgery</title><author>Lu, Jingyi ; Pan, Yunhui ; Tu, Yinfang ; Zhang, Pin ; Zhou, Jian ; Yu, Haoyong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-6f4c1aee0035c41f0b8eb60930596e2175ddd2124d25a596817dd9733de68e7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Bariatric surgery</topic><topic>Biomarkers</topic><topic>Blood Glucose</topic><topic>Blood Glucose Self-Monitoring - adverse effects</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - surgery</topic><topic>Diabetes remission</topic><topic>Gastric Bypass - adverse effects</topic><topic>Glycemic variability</topic><topic>Humans</topic><topic>Hypoglycemia</topic><topic>Hypoglycemia - etiology</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Jingyi</creatorcontrib><creatorcontrib>Pan, Yunhui</creatorcontrib><creatorcontrib>Tu, Yinfang</creatorcontrib><creatorcontrib>Zhang, Pin</creatorcontrib><creatorcontrib>Zhou, Jian</creatorcontrib><creatorcontrib>Yu, Haoyong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery for obesity and related diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Jingyi</au><au>Pan, Yunhui</au><au>Tu, Yinfang</au><au>Zhang, Pin</au><au>Zhou, Jian</au><au>Yu, Haoyong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contribution of glycemic variability to hypoglycemia, and a new marker for diabetes remission after Roux-en-Y gastric bypass surgery</atitle><jtitle>Surgery for obesity and related diseases</jtitle><addtitle>Surg Obes Relat Dis</addtitle><date>2022-05</date><risdate>2022</risdate><volume>18</volume><issue>5</issue><spage>666</spage><epage>673</epage><pages>666-673</pages><issn>1550-7289</issn><eissn>1878-7533</eissn><abstract>Diabetes remission after bariatric surgery was reported to be characterized by increased risk of hypoglycemia.
This study aimed to examine the contribution of glycemic variability (GV) to the risk of hypoglycemia, and the suitability of time in range (TIR), an emerging glycemic marker, to define diabetes remission after Roux-en-Y gastric bypass (RYGB).
A single referral center in China.
This retrospective study included 175 individuals with type 2 diabetes and obesity who underwent RYGB. Subjects were classified as remission/nonremission according to the current standard. Each participant underwent continuous glucose monitoring both before and 1 year after RYGB. GV was measured by glucose coefficient of variation (CV), and hypoglycemia was assessed by time below range (TBR).
Complete remission was achieved in 88 of the 175 participants following RYGB. In the remission group, significant correlations between postoperative CV and TBRs (r = .353–.442, both P ≤ .001) were found. Excess hypoglycemia (TBR<54 , ≥1%, TBR<70, ≥4%) increased with ascending CV quintiles (both P for trend <.05) and was significantly more frequent in subjects with glucose CV >32.2% (both P <.05). Compared with glycated hemoglobin A1C, TIR showed stronger correlation with glucose CV and risk of hypoglycemia.
Increased glycemic variability was linked to excess risk of hypoglycemia after RYGB. Furthermore, TIR may serve as a new metric, in addition to HbA1C, for defining diabetes remission.
1.Glycemic variability (GV) assessed by glucose coefficient of variation (CV) was significantly linked to hypoglycemia in patients following Roux-en-Y gastric bypass surgery (RYGB).2.A new glycemic metric, time in range (TIR), showed stronger relationship to GV and hypoglycemia as compared with A1c, and may be a promising marker for defining diabetes remission after bariatric surgery.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>35190269</pmid><doi>10.1016/j.soard.2022.01.012</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8621-4960</orcidid><orcidid>https://orcid.org/0000-0003-1105-4189</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1550-7289 |
| ispartof | Surgery for obesity and related diseases, 2022-05, Vol.18 (5), p.666-673 |
| issn | 1550-7289 1878-7533 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2631866227 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Bariatric surgery Biomarkers Blood Glucose Blood Glucose Self-Monitoring - adverse effects Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - surgery Diabetes remission Gastric Bypass - adverse effects Glycemic variability Humans Hypoglycemia Hypoglycemia - etiology Retrospective Studies |
| title | Contribution of glycemic variability to hypoglycemia, and a new marker for diabetes remission after Roux-en-Y gastric bypass surgery |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T19%3A45%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Contribution%20of%20glycemic%20variability%20to%20hypoglycemia,%20and%20a%20new%20marker%20for%20diabetes%20remission%20after%20Roux-en-Y%20gastric%20bypass%20surgery&rft.jtitle=Surgery%20for%20obesity%20and%20related%20diseases&rft.au=Lu,%20Jingyi&rft.date=2022-05&rft.volume=18&rft.issue=5&rft.spage=666&rft.epage=673&rft.pages=666-673&rft.issn=1550-7289&rft.eissn=1878-7533&rft_id=info:doi/10.1016/j.soard.2022.01.012&rft_dat=%3Cproquest_cross%3E2631866227%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2631866227&rft_id=info:pmid/35190269&rft_els_id=S1550728922000284&rfr_iscdi=true |