LPCing through the nephron accelerates diabetic kidney disease

LPCing through the nephron accelerates diabetic kidney disease

Lipid dysmetabolism is emerging as an important contributor to diabetic kidney disease, suggesting that intrarenal lipid accumulation is detrimental to kidney function. This commentary discusses the finding by Yoshioka et al., connecting tubular lipotoxicity induced by an increase in locally produce...

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Veröffentlicht in:Kidney international 2022-03, Vol.101 (3), p.454-456
Hauptverfasser: Pressly, Jeffrey D., Ge, Mengyuan, Fornoni, Alessia
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Sprache:eng
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Diabetes Mellitus
Diabetic Nephropathies - etiology
Humans
Kidney
Nephrons
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container_title Kidney international
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creator Pressly, Jeffrey D.
Ge, Mengyuan
Fornoni, Alessia
description Lipid dysmetabolism is emerging as an important contributor to diabetic kidney disease, suggesting that intrarenal lipid accumulation is detrimental to kidney function. This commentary discusses the finding by Yoshioka et al., connecting tubular lipotoxicity induced by an increase in locally produced lysophosphatidylcholine in patients with a fast progression of diabetic kidney disease, known as “fast decliner.” Insight into the lipid species in the kidney may prove beneficial for the diagnosis and stratification of patients with diabetic kidney disease.
doi_str_mv 10.1016/j.kint.2021.12.013
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subjects Diabetes Mellitus
Diabetic Nephropathies - etiology
Humans
Kidney
Nephrons
title LPCing through the nephron accelerates diabetic kidney disease
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