Synthesis of α‑Aryl Primary Amides from α‑Silyl Nitriles and Aryl Sulfoxides through [3,3]-Sigmatropic Rearrangement

A simple and efficient protocol was developed for the preparation of challenging α-aryl primary amides. This metal-free coupling process was triggered by TfOH-promoted electrophilic activation of α-silyl nitrile to generate keteniminium ion species, followed by reaction with aryl sulfoxide through [...

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Veröffentlicht in:	Organic letters 2022-03, Vol.24 (8), p.1700-1705
Hauptverfasser:	Luo, Fan, Zhou, Hui, Chen, Xiao-Bei, Liu, Xue-Jun, Chen, Xiao-Dong, Qian, Peng-Fei, Wu, Xin-Ping, Wang, Wei, Zhang, Shi-Lei
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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