The anti-Leishmania potential of bioactive compounds derived from naphthoquinones and their possible applications. A systematic review of animal studies
Leishmaniasis affects millions of people worldwide, and available treatments have severe limitations. Natural and derivative products are significant sources of innovative therapeutic agents. Naphthoquinones are natural or synthetic chemical compounds with broad biological activity. This systematic...
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| Veröffentlicht in: | Parasitology research (1987) 2022-05, Vol.121 (5), p.1247-1280 |
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| creator | Ramos-Milaré, Áquila Carolina Fernandes Herculano Oyama, Jully Murase, Letícia Sayuri Souza, João Vítor Perez Guedes, Bárbara Silva Lera-Nonose, Daniele Stéfanie Sara Lopes Monich, Mariana Terron Brustolin, Aline Ávila Demarchi, Izabel Galhardo Teixeira, Jorge Juarez Vieira Lonardoni, Maria Valdrinez Campana |
| description | Leishmaniasis affects millions of people worldwide, and available treatments have severe limitations. Natural and derivative products are significant sources of innovative therapeutic agents. Naphthoquinones are natural or synthetic chemical compounds with broad biological activity. This systematic review aimed to evaluate the potential anti-
Leishmania
activity of bioactive compounds derived from naphthoquinones in animal models. Conducted in accordance with PRISMA guidelines, two blocks of MeSH terms were assembled: group I,
Leishmania
OR Leishmaniasis; group II, Atovaquone OR Lapachol OR Beta lapachone OR Naphthoquinones. The search was performed on PubMed, Web of Science, SCOPUS, EMBASE, and Lilacs databases. Twenty-four articles were retrieved and submitted for quality assessment using the SYRCLE critical appraisal tool. The in vivo anti-
Leishmania
potential of naphthoquinones was evaluated in visceral and cutaneous leishmaniasis using several measurement parameters. Analyzed compounds varied in structure, association with reference drugs, and encapsulation using a drug delivery system. The study design, including treatment protocol, differed between studies. The findings of the studies in this systematic review indicate the anti-
Leishmania
potential of naphthoquinones in vivo, with different treatment regimens directed against different
Leishmania
species. The employed drug delivery systems improve the results concerning selectivity, distribution, and required therapeutic dose. The immunomodulatory action was shown to be beneficial to the host, favoring an adequate immune response against infection by
Leishmania
parasites since it favored Th
1
responses. All studies presented a moderate to high risk of bias. These findings suggest that more studies are needed to assess the overall effectiveness and safety of these treatments.
Graphical abstract |
| doi_str_mv | 10.1007/s00436-022-07455-1 |
| format | Article |
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Leishmania
activity of bioactive compounds derived from naphthoquinones in animal models. Conducted in accordance with PRISMA guidelines, two blocks of MeSH terms were assembled: group I,
Leishmania
OR Leishmaniasis; group II, Atovaquone OR Lapachol OR Beta lapachone OR Naphthoquinones. The search was performed on PubMed, Web of Science, SCOPUS, EMBASE, and Lilacs databases. Twenty-four articles were retrieved and submitted for quality assessment using the SYRCLE critical appraisal tool. The in vivo anti-
Leishmania
potential of naphthoquinones was evaluated in visceral and cutaneous leishmaniasis using several measurement parameters. Analyzed compounds varied in structure, association with reference drugs, and encapsulation using a drug delivery system. The study design, including treatment protocol, differed between studies. The findings of the studies in this systematic review indicate the anti-
Leishmania
potential of naphthoquinones in vivo, with different treatment regimens directed against different
Leishmania
species. The employed drug delivery systems improve the results concerning selectivity, distribution, and required therapeutic dose. The immunomodulatory action was shown to be beneficial to the host, favoring an adequate immune response against infection by
Leishmania
parasites since it favored Th
1
responses. All studies presented a moderate to high risk of bias. These findings suggest that more studies are needed to assess the overall effectiveness and safety of these treatments.
Graphical abstract</description><identifier>ISSN: 0932-0113</identifier><identifier>EISSN: 1432-1955</identifier><identifier>DOI: 10.1007/s00436-022-07455-1</identifier><identifier>PMID: 35190878</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animal models ; Animals ; Animals, Laboratory ; Antiprotozoal Agents - therapeutic use ; Atovaquone ; Bioactive compounds ; Biological activity ; Biomedical and Life Sciences ; Biomedicine ; Cutaneous leishmaniasis ; Drug delivery ; Drug delivery systems ; Drug development ; Drugs ; Health aspects ; Humans ; Immune response ; Immunology ; Immunomodulation ; Immunosuppressive agents ; Lapachone ; Leishmania ; Leishmaniasis ; Leishmaniasis, Cutaneous - drug therapy ; Lymphocytes T ; Medical innovations ; Medical Microbiology ; Microbiology ; Naphthoquinones - chemistry ; Naphthoquinones - pharmacology ; Parasitic diseases ; Pentamidine isethionate ; Quality control ; Reviews ; Systematic review ; Treatment and Prophylaxis - Review ; Vehicles</subject><ispartof>Parasitology research (1987), 2022-05, Vol.121 (5), p.1247-1280</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>COPYRIGHT 2022 Springer</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-6c9f26ad784d5277d2d42c8baf2145a52bd422c188df496fec8abc6c6d7c5ad33</citedby><cites>FETCH-LOGICAL-c442t-6c9f26ad784d5277d2d42c8baf2145a52bd422c188df496fec8abc6c6d7c5ad33</cites><orcidid>0000-0001-9068-7958</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00436-022-07455-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00436-022-07455-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35190878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramos-Milaré, Áquila Carolina Fernandes Herculano</creatorcontrib><creatorcontrib>Oyama, Jully</creatorcontrib><creatorcontrib>Murase, Letícia Sayuri</creatorcontrib><creatorcontrib>Souza, João Vítor Perez</creatorcontrib><creatorcontrib>Guedes, Bárbara Silva</creatorcontrib><creatorcontrib>Lera-Nonose, Daniele Stéfanie Sara Lopes</creatorcontrib><creatorcontrib>Monich, Mariana Terron</creatorcontrib><creatorcontrib>Brustolin, Aline Ávila</creatorcontrib><creatorcontrib>Demarchi, Izabel Galhardo</creatorcontrib><creatorcontrib>Teixeira, Jorge Juarez Vieira</creatorcontrib><creatorcontrib>Lonardoni, Maria Valdrinez Campana</creatorcontrib><title>The anti-Leishmania potential of bioactive compounds derived from naphthoquinones and their possible applications. A systematic review of animal studies</title><title>Parasitology research (1987)</title><addtitle>Parasitol Res</addtitle><addtitle>Parasitol Res</addtitle><description>Leishmaniasis affects millions of people worldwide, and available treatments have severe limitations. Natural and derivative products are significant sources of innovative therapeutic agents. Naphthoquinones are natural or synthetic chemical compounds with broad biological activity. This systematic review aimed to evaluate the potential anti-
Leishmania
activity of bioactive compounds derived from naphthoquinones in animal models. Conducted in accordance with PRISMA guidelines, two blocks of MeSH terms were assembled: group I,
Leishmania
OR Leishmaniasis; group II, Atovaquone OR Lapachol OR Beta lapachone OR Naphthoquinones. The search was performed on PubMed, Web of Science, SCOPUS, EMBASE, and Lilacs databases. Twenty-four articles were retrieved and submitted for quality assessment using the SYRCLE critical appraisal tool. The in vivo anti-
Leishmania
potential of naphthoquinones was evaluated in visceral and cutaneous leishmaniasis using several measurement parameters. Analyzed compounds varied in structure, association with reference drugs, and encapsulation using a drug delivery system. The study design, including treatment protocol, differed between studies. The findings of the studies in this systematic review indicate the anti-
Leishmania
potential of naphthoquinones in vivo, with different treatment regimens directed against different
Leishmania
species. The employed drug delivery systems improve the results concerning selectivity, distribution, and required therapeutic dose. The immunomodulatory action was shown to be beneficial to the host, favoring an adequate immune response against infection by
Leishmania
parasites since it favored Th
1
responses. All studies presented a moderate to high risk of bias. These findings suggest that more studies are needed to assess the overall effectiveness and safety of these treatments.
Graphical abstract</description><subject>Animal models</subject><subject>Animals</subject><subject>Animals, Laboratory</subject><subject>Antiprotozoal Agents - therapeutic use</subject><subject>Atovaquone</subject><subject>Bioactive compounds</subject><subject>Biological activity</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cutaneous leishmaniasis</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Drug development</subject><subject>Drugs</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immunology</subject><subject>Immunomodulation</subject><subject>Immunosuppressive agents</subject><subject>Lapachone</subject><subject>Leishmania</subject><subject>Leishmaniasis</subject><subject>Leishmaniasis, Cutaneous - drug therapy</subject><subject>Lymphocytes T</subject><subject>Medical innovations</subject><subject>Medical Microbiology</subject><subject>Microbiology</subject><subject>Naphthoquinones - chemistry</subject><subject>Naphthoquinones - pharmacology</subject><subject>Parasitic diseases</subject><subject>Pentamidine isethionate</subject><subject>Quality control</subject><subject>Reviews</subject><subject>Systematic review</subject><subject>Treatment and Prophylaxis - Review</subject><subject>Vehicles</subject><issn>0932-0113</issn><issn>1432-1955</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Ustu1DAUjRCIDoUfYIEssekmg-3YeSxHFRSkkdiUteXYN42rxA62U9Q_4XO5YQoVCCEv7Ht9zrnPonjN6J5R2rxLlIqqLinnJW2ElCV7UuyYqHjJOimfFjva4ZsyVp0VL1K6pZQ1tRDPi7NKso62Tbsrvl-PQLTPrjyCS-OsvdNkCRnQpScSBtK7oE12d0BMmJewepuIhYgOS4YYZuL1MuYxfF2dDx4SqlmSR3ARdVJy_YQBlmVyRmcXfNqTA0n3KcOMtiER7hx82wJh6BlDprxaB-ll8WzQU4JXD_d58eXD--vLj-Xx89Wny8OxNELwXNamG3itbdMKK3nTWG4FN22vB86E1JL3aHPD2tYOoqsHMK3uTW1q2xipbVWdFxcn3SViCZCyml0yME3aQ1iT4nXF2lpIyhD69i_obVijx-wQJVopueDdI-pGT6CcH0KO2myi6lB3XUdxXpvW_h8oPBZmZ7CPg0P_HwR-IpiIXY0wqCViv-K9YlRt66BO66AQrX6ug9pIbx4yXvsZ7G_Kr_kjoDoBEn75G4iPJf1H9gflmcIP</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>Ramos-Milaré, Áquila Carolina Fernandes Herculano</creator><creator>Oyama, Jully</creator><creator>Murase, Letícia Sayuri</creator><creator>Souza, João Vítor Perez</creator><creator>Guedes, Bárbara Silva</creator><creator>Lera-Nonose, Daniele Stéfanie Sara Lopes</creator><creator>Monich, Mariana Terron</creator><creator>Brustolin, Aline Ávila</creator><creator>Demarchi, Izabel Galhardo</creator><creator>Teixeira, Jorge Juarez Vieira</creator><creator>Lonardoni, Maria Valdrinez Campana</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9068-7958</orcidid></search><sort><creationdate>20220501</creationdate><title>The anti-Leishmania potential of bioactive compounds derived from naphthoquinones and their possible applications. A systematic review of animal studies</title><author>Ramos-Milaré, Áquila Carolina Fernandes Herculano ; Oyama, Jully ; Murase, Letícia Sayuri ; Souza, João Vítor Perez ; Guedes, Bárbara Silva ; Lera-Nonose, Daniele Stéfanie Sara Lopes ; Monich, Mariana Terron ; Brustolin, Aline Ávila ; Demarchi, Izabel Galhardo ; Teixeira, Jorge Juarez Vieira ; Lonardoni, Maria Valdrinez Campana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-6c9f26ad784d5277d2d42c8baf2145a52bd422c188df496fec8abc6c6d7c5ad33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animal models</topic><topic>Animals</topic><topic>Animals, Laboratory</topic><topic>Antiprotozoal Agents - therapeutic use</topic><topic>Atovaquone</topic><topic>Bioactive compounds</topic><topic>Biological activity</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cutaneous leishmaniasis</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>Drug development</topic><topic>Drugs</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immunology</topic><topic>Immunomodulation</topic><topic>Immunosuppressive agents</topic><topic>Lapachone</topic><topic>Leishmania</topic><topic>Leishmaniasis</topic><topic>Leishmaniasis, Cutaneous - drug therapy</topic><topic>Lymphocytes T</topic><topic>Medical innovations</topic><topic>Medical Microbiology</topic><topic>Microbiology</topic><topic>Naphthoquinones - chemistry</topic><topic>Naphthoquinones - pharmacology</topic><topic>Parasitic diseases</topic><topic>Pentamidine isethionate</topic><topic>Quality control</topic><topic>Reviews</topic><topic>Systematic review</topic><topic>Treatment and Prophylaxis - Review</topic><topic>Vehicles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramos-Milaré, Áquila Carolina Fernandes Herculano</creatorcontrib><creatorcontrib>Oyama, Jully</creatorcontrib><creatorcontrib>Murase, Letícia Sayuri</creatorcontrib><creatorcontrib>Souza, João Vítor Perez</creatorcontrib><creatorcontrib>Guedes, Bárbara Silva</creatorcontrib><creatorcontrib>Lera-Nonose, Daniele Stéfanie Sara Lopes</creatorcontrib><creatorcontrib>Monich, Mariana Terron</creatorcontrib><creatorcontrib>Brustolin, Aline Ávila</creatorcontrib><creatorcontrib>Demarchi, Izabel Galhardo</creatorcontrib><creatorcontrib>Teixeira, Jorge Juarez Vieira</creatorcontrib><creatorcontrib>Lonardoni, Maria Valdrinez Campana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Parasitology research (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramos-Milaré, Áquila Carolina Fernandes Herculano</au><au>Oyama, Jully</au><au>Murase, Letícia Sayuri</au><au>Souza, João Vítor Perez</au><au>Guedes, Bárbara Silva</au><au>Lera-Nonose, Daniele Stéfanie Sara Lopes</au><au>Monich, Mariana Terron</au><au>Brustolin, Aline Ávila</au><au>Demarchi, Izabel Galhardo</au><au>Teixeira, Jorge Juarez Vieira</au><au>Lonardoni, Maria Valdrinez Campana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The anti-Leishmania potential of bioactive compounds derived from naphthoquinones and their possible applications. A systematic review of animal studies</atitle><jtitle>Parasitology research (1987)</jtitle><stitle>Parasitol Res</stitle><addtitle>Parasitol Res</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>121</volume><issue>5</issue><spage>1247</spage><epage>1280</epage><pages>1247-1280</pages><issn>0932-0113</issn><eissn>1432-1955</eissn><abstract>Leishmaniasis affects millions of people worldwide, and available treatments have severe limitations. Natural and derivative products are significant sources of innovative therapeutic agents. Naphthoquinones are natural or synthetic chemical compounds with broad biological activity. This systematic review aimed to evaluate the potential anti-
Leishmania
activity of bioactive compounds derived from naphthoquinones in animal models. Conducted in accordance with PRISMA guidelines, two blocks of MeSH terms were assembled: group I,
Leishmania
OR Leishmaniasis; group II, Atovaquone OR Lapachol OR Beta lapachone OR Naphthoquinones. The search was performed on PubMed, Web of Science, SCOPUS, EMBASE, and Lilacs databases. Twenty-four articles were retrieved and submitted for quality assessment using the SYRCLE critical appraisal tool. The in vivo anti-
Leishmania
potential of naphthoquinones was evaluated in visceral and cutaneous leishmaniasis using several measurement parameters. Analyzed compounds varied in structure, association with reference drugs, and encapsulation using a drug delivery system. The study design, including treatment protocol, differed between studies. The findings of the studies in this systematic review indicate the anti-
Leishmania
potential of naphthoquinones in vivo, with different treatment regimens directed against different
Leishmania
species. The employed drug delivery systems improve the results concerning selectivity, distribution, and required therapeutic dose. The immunomodulatory action was shown to be beneficial to the host, favoring an adequate immune response against infection by
Leishmania
parasites since it favored Th
1
responses. All studies presented a moderate to high risk of bias. These findings suggest that more studies are needed to assess the overall effectiveness and safety of these treatments.
Graphical abstract</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35190878</pmid><doi>10.1007/s00436-022-07455-1</doi><tpages>34</tpages><orcidid>https://orcid.org/0000-0001-9068-7958</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0932-0113 |
| ispartof | Parasitology research (1987), 2022-05, Vol.121 (5), p.1247-1280 |
| issn | 0932-0113 1432-1955 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2631864501 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Animal models Animals Animals, Laboratory Antiprotozoal Agents - therapeutic use Atovaquone Bioactive compounds Biological activity Biomedical and Life Sciences Biomedicine Cutaneous leishmaniasis Drug delivery Drug delivery systems Drug development Drugs Health aspects Humans Immune response Immunology Immunomodulation Immunosuppressive agents Lapachone Leishmania Leishmaniasis Leishmaniasis, Cutaneous - drug therapy Lymphocytes T Medical innovations Medical Microbiology Microbiology Naphthoquinones - chemistry Naphthoquinones - pharmacology Parasitic diseases Pentamidine isethionate Quality control Reviews Systematic review Treatment and Prophylaxis - Review Vehicles |
| title | The anti-Leishmania potential of bioactive compounds derived from naphthoquinones and their possible applications. A systematic review of animal studies |
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