Environmental toxic metal contaminants and risk of stroke: a systematic review and meta-analysis
The relationship between toxic metals in the environment and clinical stroke risk remains unclear, although their role as immunotoxicants and carcinogens has been well established. We conducted a systematic review of the relationship between five metals (arsenic, mercury, copper, cadmium, and lead)...
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| Veröffentlicht in: | Environmental science and pollution research international 2022-05, Vol.29 (22), p.32545-32565 |
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| creator | Bao, Qiang-Ji Zhao, Kai Guo, Yu Wu, Xin-Ting Yang, Jin-Cai Yang, Ming-Fei |
| description | The relationship between toxic metals in the environment and clinical stroke risk remains unclear, although their role as immunotoxicants and carcinogens has been well established. We conducted a systematic review of the relationship between five metals (arsenic, mercury, copper, cadmium, and lead) and stroke. First, we comprehensively searched 3 databases (Pubmed, EMBASE, and Cochrane) from inception until June 2021. Random-effects meta-analyses, pooled relative risks (RR) and 95% confidence intervals (CI) were applied to evaluate the effect value. We finally identified 38 studies involving 642,014 non-overlapping participants. Comparing the highest vs. lowest baseline levels, chronic exposure to lead (RR = 1.07; 95%CI,1.00–1.14), cadmium (RR = 1.30; 95%CI,1.13–1.48), and copper (RR = 1.19; 95%CI,1.04–1.36) were significantly associated with stroke risks. However, the other two metals (arsenic and mercury) had less effect on stroke risk. Further analysis indicated that the association was likely in a metal dose-dependent manner. The results may further support the possibility that environmental toxic metal contaminants in recent years are associated with the increased risk of stroke. |
| doi_str_mv | 10.1007/s11356-022-18866-z |
| format | Article |
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We conducted a systematic review of the relationship between five metals (arsenic, mercury, copper, cadmium, and lead) and stroke. First, we comprehensively searched 3 databases (Pubmed, EMBASE, and Cochrane) from inception until June 2021. Random-effects meta-analyses, pooled relative risks (RR) and 95% confidence intervals (CI) were applied to evaluate the effect value. We finally identified 38 studies involving 642,014 non-overlapping participants. Comparing the highest vs. lowest baseline levels, chronic exposure to lead (RR = 1.07; 95%CI,1.00–1.14), cadmium (RR = 1.30; 95%CI,1.13–1.48), and copper (RR = 1.19; 95%CI,1.04–1.36) were significantly associated with stroke risks. However, the other two metals (arsenic and mercury) had less effect on stroke risk. Further analysis indicated that the association was likely in a metal dose-dependent manner. The results may further support the possibility that environmental toxic metal contaminants in recent years are associated with the increased risk of stroke.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-022-18866-z</identifier><identifier>PMID: 35190994</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aquatic Pollution ; Arsenic ; Arsenic - analysis ; Atmospheric Protection/Air Quality Control/Air Pollution ; Cadmium ; Cadmium - analysis ; Carcinogens ; Chronic exposure ; Confidence intervals ; Contaminants ; Copper ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental science ; Health risks ; Heavy Metal Poisoning ; Heavy metals ; Humans ; Lead ; Mercury ; Mercury (metal) ; Mercury - analysis ; Meta-analysis ; Metals ; Review Article ; Risk analysis ; Risk assessment ; Stroke - chemically induced ; Stroke - epidemiology ; Systematic review ; Waste Water Technology ; Water Management ; Water Pollution Control</subject><ispartof>Environmental science and pollution research international, 2022-05, Vol.29 (22), p.32545-32565</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. 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Academic</collection><jtitle>Environmental science and pollution research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bao, Qiang-Ji</au><au>Zhao, Kai</au><au>Guo, Yu</au><au>Wu, Xin-Ting</au><au>Yang, Jin-Cai</au><au>Yang, Ming-Fei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Environmental toxic metal contaminants and risk of stroke: a systematic review and meta-analysis</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>29</volume><issue>22</issue><spage>32545</spage><epage>32565</epage><pages>32545-32565</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>The relationship between toxic metals in the environment and clinical stroke risk remains unclear, although their role as immunotoxicants and carcinogens has been well established. We conducted a systematic review of the relationship between five metals (arsenic, mercury, copper, cadmium, and lead) and stroke. First, we comprehensively searched 3 databases (Pubmed, EMBASE, and Cochrane) from inception until June 2021. Random-effects meta-analyses, pooled relative risks (RR) and 95% confidence intervals (CI) were applied to evaluate the effect value. We finally identified 38 studies involving 642,014 non-overlapping participants. Comparing the highest vs. lowest baseline levels, chronic exposure to lead (RR = 1.07; 95%CI,1.00–1.14), cadmium (RR = 1.30; 95%CI,1.13–1.48), and copper (RR = 1.19; 95%CI,1.04–1.36) were significantly associated with stroke risks. However, the other two metals (arsenic and mercury) had less effect on stroke risk. Further analysis indicated that the association was likely in a metal dose-dependent manner. The results may further support the possibility that environmental toxic metal contaminants in recent years are associated with the increased risk of stroke.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35190994</pmid><doi>10.1007/s11356-022-18866-z</doi><tpages>21</tpages></addata></record> |
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| subjects | Aquatic Pollution Arsenic Arsenic - analysis Atmospheric Protection/Air Quality Control/Air Pollution Cadmium Cadmium - analysis Carcinogens Chronic exposure Confidence intervals Contaminants Copper Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Health risks Heavy Metal Poisoning Heavy metals Humans Lead Mercury Mercury (metal) Mercury - analysis Meta-analysis Metals Review Article Risk analysis Risk assessment Stroke - chemically induced Stroke - epidemiology Systematic review Waste Water Technology Water Management Water Pollution Control |
| title | Environmental toxic metal contaminants and risk of stroke: a systematic review and meta-analysis |
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