Epidemiology and geographic distribution of BRCA1-2 and DNA Damage response genes pathogenic variants in pancreatic ductal adenocarcinoma patients

•BRCA1-2 mutations (gBRCA1-2) are responsible for PDAC in 15–20% of familiar cases.•gBRCA1-2 and DDR genes mutations (gDDR) emerged as therapeutic targets for PDAC.•Rigorous studies on gBRCA1-2/DDR geographic distribution are lacking in PDAC.•Improving the gBRCA1-2/DDR epidemiology may lead to pharm...

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Veröffentlicht in:	Cancer treatment reviews 2022-03, Vol.104, p.102357-102357, Article 102357
Hauptverfasser:	Macchini, Marina, Centonze, Federico, Peretti, Umberto, Orsi, Giulia, Militello, Anna Maria, Valente, Maria Maddalena, Cascinu, Stefano, Reni, Michele
Format:	Artikel
Sprache:	eng
Schlagworte:	BRCA1 Protein - genetics BRCA1-2 pathogenic variants BRCA2 Protein Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - epidemiology Carcinoma, Pancreatic Ductal - genetics DNA Damage - genetics DNA Damage Response pathogenic variants Epidemiology Familiar pancreatic cancer Germ-Line Mutation Humans Pancreatic adenocarcinoma Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - epidemiology Pancreatic Neoplasms - genetics Pharmaco-ethnicity Prognosis
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