Synthesis and antiviral activities of quinazolinamine–coumarin conjugates toward chikungunya and hepatitis C viruses

Development of new drugs with broad-spectrum to combat RNA viruses would be beneficial to mankind but faces a great challenge. We designed and efficiently synthesized a series of quinazolin-4-amine–SCH2–coumarin conjugated compounds. Our data of the virus-cell-based assay show five new conjugates in...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	European journal of medicinal chemistry 2022-03, Vol.232, p.114164-114164, Article 114164
Hauptverfasser:	Hwu, Jih Ru, Kapoor, Mohit, Gupta, Nitesh K., Tsay, Shwu-Chen, Huang, Wen-Chieh, Tan, Kui-Thong, Hu, Yu-Chen, Lyssen, Pieter, Neyts, Johan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - pharmacology Broad-spectrum Chikungunya Fever Chikungunya virus Coumarin Coumarins - pharmacology Hepacivirus Hepatitis C virus Humans Quinazolin-4-amine Structure–activity relationship Virus Replication
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!