Small molecules targeting γ-secretase and their potential biological applications

The γ-secretase is a large transmembrane protein complex composed of four distinct units. It has aroused numerous attention over the past two decades as its intriguing role in mediating intramembrane proteolysis. γ-Secretase controls the cleavage of a broad ranged substrates, part of which have impl...

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Veröffentlicht in:	European journal of medicinal chemistry 2022-03, Vol.232, p.114169-114169, Article 114169
Hauptverfasser:	Wen, Jiachen, Liu, Dan, Zhao, Linxiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - pathology Amyloid Precursor Protein Secretases - metabolism Anti-Alzheimer's disease Anti-tumor Cell Membrane - metabolism Humans Notch signaling pathway γ-Secretase inhibitor γ-Secretase modulator
Online-Zugang:	Volltext
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