FOXD3 and GAB2 as a pair of rivals antagonistically control hepatocellular carcinogenesis

Our previous study demonstrated that GAB2 promoted tumorigenesis in liver tissue and was a potential target for the treatment of hepatocellular carcinoma (HCC). Here, we identified that the tumour suppressor protein Forkhead box D3 (Foxd3) is a transcriptional repressor of the Gab2 gene. In human HC...

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Veröffentlicht in:	The FEBS journal 2022-08, Vol.289 (15), p.4536-4548
Hauptverfasser:	Liu, Ruimin, Sun, Yan, Chen, Shuai, Hong, Yun, Lu, Zhongxian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tissues Carcinogenesis Carcinogens Cell migration Cell proliferation Diethylnitrosamine Ectopic expression Forkhead protein Foxd3 Gab2 Hepatocellular carcinoma Janus kinase 2 Kinases Liver cancer Phosphorylation Proteins Stat3 protein Tumor suppressor genes Tumorigenesis Tumors
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