Glutathione production by Saccharomyces cerevisiae: current state and perspectives
Glutathione (L-γ-glutamyl-cysteinyl-glycine, GSH) is a tripeptide synthesized through consecutive enzymatic reactions. Among its several metabolic functions in cells, the main one is the potential to act as an endogenous antioxidant agent. GSH has been the focus of numerous studies not only due to i...
Gespeichert in:
| Veröffentlicht in: | Applied microbiology and biotechnology 2022-03, Vol.106 (5-6), p.1879-1894 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1894 |
|---|---|
| container_issue | 5-6 |
| container_start_page | 1879 |
| container_title | Applied microbiology and biotechnology |
| container_volume | 106 |
| creator | Santos, Lucielen Oliveira Silva, Pedro Garcia Pereira Lemos Junior, Wilson José Fernandes de Oliveira, Vanessa Sales Anschau, Andréia |
| description | Glutathione (L-γ-glutamyl-cysteinyl-glycine, GSH) is a tripeptide synthesized through consecutive enzymatic reactions. Among its several metabolic functions in cells, the main one is the potential to act as an endogenous antioxidant agent. GSH has been the focus of numerous studies not only due to its role in the redox status of biological systems but also due to its biotechnological characteristics. GSH is usually obtained by fermentation and shows a variety of applications by the pharmaceutical and food industry. Therefore, the search for new strategies to improve the production of GSH during fermentation is crucial. This mini review brings together recent papers regarding the principal parameters of the biotechnological production of GSH by
Saccharomyces cerevisiae.
In this context, aspects, such as the medium composition (amino acids, alternative raw materials) and the use of technological approaches (control of osmotic and pressure conditions, magnetic field (MF) application, fed-batch process) were considered, along with genetic engineering knowledge, trends, and challenges in viable GSH production.
Key points
•
Saccharomyces cerevisiae has shown potential for glutathione production.
•
Improved technological approaches increases glutathione production.
•
Genetic engineering in Saccharomyces cerevisiae improves glutathione production. |
| doi_str_mv | 10.1007/s00253-022-11826-0 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2630926387</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A697427053</galeid><sourcerecordid>A697427053</sourcerecordid><originalsourceid>FETCH-LOGICAL-c403t-b9c0f33525f77144381075089c4bea1c7dc136482c78e5b894529d9754a8e0ff3</originalsourceid><addsrcrecordid>eNp9kUtLxDAUhYMoOj7-gAspuHFTvXk1iTsRXyAIPtYhTW_HSqcdk1aYf2_GGRVcuEkC-c7hwEfIIYVTCqDOIgCTPAfGcko1K3LYIBMqOMuhoGKTTIAqmStp9A7ZjfENgDJdFNtkh8vEU8Mm5PGmHQc3vDZ9h9k89NXoh_TOykX25Lx_daGfLTzGzGPAjyY2Ds8zP4aA3ZDFlMTMdVU2xxDnmKIfGPfJVu3aiAfre4-8XF89X97m9w83d5cX97kXwIe8NB5qziWTtVJUCK4pKAnaeFGio15VnvJCaOaVRllqIyQzlVFSOI1Q13yPnKx60-z3EeNgZ0302Lauw36MlhUcTDq0SujxH_StH0OX1iVKgJRGcv5LTV2LtunqfgjOL0vtRWGUYArkkmIryoc-xoC1nYdm5sLCUrBLL3blxSYv9suLhRQ6Wg8YyxlWP5FvEQngKyCmr26K4XfhP7WfZISWVw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2640559533</pqid></control><display><type>article</type><title>Glutathione production by Saccharomyces cerevisiae: current state and perspectives</title><source>SpringerLink Journals</source><creator>Santos, Lucielen Oliveira ; Silva, Pedro Garcia Pereira ; Lemos Junior, Wilson José Fernandes ; de Oliveira, Vanessa Sales ; Anschau, Andréia</creator><creatorcontrib>Santos, Lucielen Oliveira ; Silva, Pedro Garcia Pereira ; Lemos Junior, Wilson José Fernandes ; de Oliveira, Vanessa Sales ; Anschau, Andréia</creatorcontrib><description>Glutathione (L-γ-glutamyl-cysteinyl-glycine, GSH) is a tripeptide synthesized through consecutive enzymatic reactions. Among its several metabolic functions in cells, the main one is the potential to act as an endogenous antioxidant agent. GSH has been the focus of numerous studies not only due to its role in the redox status of biological systems but also due to its biotechnological characteristics. GSH is usually obtained by fermentation and shows a variety of applications by the pharmaceutical and food industry. Therefore, the search for new strategies to improve the production of GSH during fermentation is crucial. This mini review brings together recent papers regarding the principal parameters of the biotechnological production of GSH by
Saccharomyces cerevisiae.
In this context, aspects, such as the medium composition (amino acids, alternative raw materials) and the use of technological approaches (control of osmotic and pressure conditions, magnetic field (MF) application, fed-batch process) were considered, along with genetic engineering knowledge, trends, and challenges in viable GSH production.
Key points
•
Saccharomyces cerevisiae has shown potential for glutathione production.
•
Improved technological approaches increases glutathione production.
•
Genetic engineering in Saccharomyces cerevisiae improves glutathione production.</description><identifier>ISSN: 0175-7598</identifier><identifier>EISSN: 1432-0614</identifier><identifier>DOI: 10.1007/s00253-022-11826-0</identifier><identifier>PMID: 35182192</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Amino acids ; Analysis ; Antioxidants ; Batch culture ; Biomedical and Life Sciences ; Biotechnology ; Brewer's yeast ; Chemical synthesis ; Fermentation ; Food industry ; Fungi ; Genetic aspects ; Genetic engineering ; Glutathione ; Glycine ; Life Sciences ; Magnetic fields ; Methods ; Microbial Genetics and Genomics ; Microbiology ; Mini-Review ; Raw materials ; Saccharomyces cerevisiae ; Yeast</subject><ispartof>Applied microbiology and biotechnology, 2022-03, Vol.106 (5-6), p.1879-1894</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>COPYRIGHT 2022 Springer</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-b9c0f33525f77144381075089c4bea1c7dc136482c78e5b894529d9754a8e0ff3</citedby><cites>FETCH-LOGICAL-c403t-b9c0f33525f77144381075089c4bea1c7dc136482c78e5b894529d9754a8e0ff3</cites><orcidid>0000-0002-2990-7656 ; 0000-0003-1459-9715 ; 0000-0002-2565-6570 ; 0000-0002-5912-6148 ; 0000-0002-2623-9744</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00253-022-11826-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00253-022-11826-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35182192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santos, Lucielen Oliveira</creatorcontrib><creatorcontrib>Silva, Pedro Garcia Pereira</creatorcontrib><creatorcontrib>Lemos Junior, Wilson José Fernandes</creatorcontrib><creatorcontrib>de Oliveira, Vanessa Sales</creatorcontrib><creatorcontrib>Anschau, Andréia</creatorcontrib><title>Glutathione production by Saccharomyces cerevisiae: current state and perspectives</title><title>Applied microbiology and biotechnology</title><addtitle>Appl Microbiol Biotechnol</addtitle><addtitle>Appl Microbiol Biotechnol</addtitle><description>Glutathione (L-γ-glutamyl-cysteinyl-glycine, GSH) is a tripeptide synthesized through consecutive enzymatic reactions. Among its several metabolic functions in cells, the main one is the potential to act as an endogenous antioxidant agent. GSH has been the focus of numerous studies not only due to its role in the redox status of biological systems but also due to its biotechnological characteristics. GSH is usually obtained by fermentation and shows a variety of applications by the pharmaceutical and food industry. Therefore, the search for new strategies to improve the production of GSH during fermentation is crucial. This mini review brings together recent papers regarding the principal parameters of the biotechnological production of GSH by
Saccharomyces cerevisiae.
In this context, aspects, such as the medium composition (amino acids, alternative raw materials) and the use of technological approaches (control of osmotic and pressure conditions, magnetic field (MF) application, fed-batch process) were considered, along with genetic engineering knowledge, trends, and challenges in viable GSH production.
Key points
•
Saccharomyces cerevisiae has shown potential for glutathione production.
•
Improved technological approaches increases glutathione production.
•
Genetic engineering in Saccharomyces cerevisiae improves glutathione production.</description><subject>Amino acids</subject><subject>Analysis</subject><subject>Antioxidants</subject><subject>Batch culture</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Brewer's yeast</subject><subject>Chemical synthesis</subject><subject>Fermentation</subject><subject>Food industry</subject><subject>Fungi</subject><subject>Genetic aspects</subject><subject>Genetic engineering</subject><subject>Glutathione</subject><subject>Glycine</subject><subject>Life Sciences</subject><subject>Magnetic fields</subject><subject>Methods</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbiology</subject><subject>Mini-Review</subject><subject>Raw materials</subject><subject>Saccharomyces cerevisiae</subject><subject>Yeast</subject><issn>0175-7598</issn><issn>1432-0614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kUtLxDAUhYMoOj7-gAspuHFTvXk1iTsRXyAIPtYhTW_HSqcdk1aYf2_GGRVcuEkC-c7hwEfIIYVTCqDOIgCTPAfGcko1K3LYIBMqOMuhoGKTTIAqmStp9A7ZjfENgDJdFNtkh8vEU8Mm5PGmHQc3vDZ9h9k89NXoh_TOykX25Lx_daGfLTzGzGPAjyY2Ds8zP4aA3ZDFlMTMdVU2xxDnmKIfGPfJVu3aiAfre4-8XF89X97m9w83d5cX97kXwIe8NB5qziWTtVJUCK4pKAnaeFGio15VnvJCaOaVRllqIyQzlVFSOI1Q13yPnKx60-z3EeNgZ0302Lauw36MlhUcTDq0SujxH_StH0OX1iVKgJRGcv5LTV2LtunqfgjOL0vtRWGUYArkkmIryoc-xoC1nYdm5sLCUrBLL3blxSYv9suLhRQ6Wg8YyxlWP5FvEQngKyCmr26K4XfhP7WfZISWVw</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Santos, Lucielen Oliveira</creator><creator>Silva, Pedro Garcia Pereira</creator><creator>Lemos Junior, Wilson José Fernandes</creator><creator>de Oliveira, Vanessa Sales</creator><creator>Anschau, Andréia</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>LK8</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2990-7656</orcidid><orcidid>https://orcid.org/0000-0003-1459-9715</orcidid><orcidid>https://orcid.org/0000-0002-2565-6570</orcidid><orcidid>https://orcid.org/0000-0002-5912-6148</orcidid><orcidid>https://orcid.org/0000-0002-2623-9744</orcidid></search><sort><creationdate>20220301</creationdate><title>Glutathione production by Saccharomyces cerevisiae: current state and perspectives</title><author>Santos, Lucielen Oliveira ; Silva, Pedro Garcia Pereira ; Lemos Junior, Wilson José Fernandes ; de Oliveira, Vanessa Sales ; Anschau, Andréia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-b9c0f33525f77144381075089c4bea1c7dc136482c78e5b894529d9754a8e0ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Amino acids</topic><topic>Analysis</topic><topic>Antioxidants</topic><topic>Batch culture</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Brewer's yeast</topic><topic>Chemical synthesis</topic><topic>Fermentation</topic><topic>Food industry</topic><topic>Fungi</topic><topic>Genetic aspects</topic><topic>Genetic engineering</topic><topic>Glutathione</topic><topic>Glycine</topic><topic>Life Sciences</topic><topic>Magnetic fields</topic><topic>Methods</topic><topic>Microbial Genetics and Genomics</topic><topic>Microbiology</topic><topic>Mini-Review</topic><topic>Raw materials</topic><topic>Saccharomyces cerevisiae</topic><topic>Yeast</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santos, Lucielen Oliveira</creatorcontrib><creatorcontrib>Silva, Pedro Garcia Pereira</creatorcontrib><creatorcontrib>Lemos Junior, Wilson José Fernandes</creatorcontrib><creatorcontrib>de Oliveira, Vanessa Sales</creatorcontrib><creatorcontrib>Anschau, Andréia</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>ABI/INFORM Collection</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ProQuest Biological Science Collection</collection><collection>ABI/INFORM Global</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Applied microbiology and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santos, Lucielen Oliveira</au><au>Silva, Pedro Garcia Pereira</au><au>Lemos Junior, Wilson José Fernandes</au><au>de Oliveira, Vanessa Sales</au><au>Anschau, Andréia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutathione production by Saccharomyces cerevisiae: current state and perspectives</atitle><jtitle>Applied microbiology and biotechnology</jtitle><stitle>Appl Microbiol Biotechnol</stitle><addtitle>Appl Microbiol Biotechnol</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>106</volume><issue>5-6</issue><spage>1879</spage><epage>1894</epage><pages>1879-1894</pages><issn>0175-7598</issn><eissn>1432-0614</eissn><abstract>Glutathione (L-γ-glutamyl-cysteinyl-glycine, GSH) is a tripeptide synthesized through consecutive enzymatic reactions. Among its several metabolic functions in cells, the main one is the potential to act as an endogenous antioxidant agent. GSH has been the focus of numerous studies not only due to its role in the redox status of biological systems but also due to its biotechnological characteristics. GSH is usually obtained by fermentation and shows a variety of applications by the pharmaceutical and food industry. Therefore, the search for new strategies to improve the production of GSH during fermentation is crucial. This mini review brings together recent papers regarding the principal parameters of the biotechnological production of GSH by
Saccharomyces cerevisiae.
In this context, aspects, such as the medium composition (amino acids, alternative raw materials) and the use of technological approaches (control of osmotic and pressure conditions, magnetic field (MF) application, fed-batch process) were considered, along with genetic engineering knowledge, trends, and challenges in viable GSH production.
Key points
•
Saccharomyces cerevisiae has shown potential for glutathione production.
•
Improved technological approaches increases glutathione production.
•
Genetic engineering in Saccharomyces cerevisiae improves glutathione production.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35182192</pmid><doi>10.1007/s00253-022-11826-0</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-2990-7656</orcidid><orcidid>https://orcid.org/0000-0003-1459-9715</orcidid><orcidid>https://orcid.org/0000-0002-2565-6570</orcidid><orcidid>https://orcid.org/0000-0002-5912-6148</orcidid><orcidid>https://orcid.org/0000-0002-2623-9744</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0175-7598 |
| ispartof | Applied microbiology and biotechnology, 2022-03, Vol.106 (5-6), p.1879-1894 |
| issn | 0175-7598 1432-0614 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2630926387 |
| source | SpringerLink Journals |
| subjects | Amino acids Analysis Antioxidants Batch culture Biomedical and Life Sciences Biotechnology Brewer's yeast Chemical synthesis Fermentation Food industry Fungi Genetic aspects Genetic engineering Glutathione Glycine Life Sciences Magnetic fields Methods Microbial Genetics and Genomics Microbiology Mini-Review Raw materials Saccharomyces cerevisiae Yeast |
| title | Glutathione production by Saccharomyces cerevisiae: current state and perspectives |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T15%3A11%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Glutathione%20production%20by%20Saccharomyces%20cerevisiae:%20current%20state%20and%20perspectives&rft.jtitle=Applied%20microbiology%20and%20biotechnology&rft.au=Santos,%20Lucielen%20Oliveira&rft.date=2022-03-01&rft.volume=106&rft.issue=5-6&rft.spage=1879&rft.epage=1894&rft.pages=1879-1894&rft.issn=0175-7598&rft.eissn=1432-0614&rft_id=info:doi/10.1007/s00253-022-11826-0&rft_dat=%3Cgale_proqu%3EA697427053%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2640559533&rft_id=info:pmid/35182192&rft_galeid=A697427053&rfr_iscdi=true |