Veno-occlusive disease of the lung after allogeneic haematopoietic stem-cell transplantation: An autopsy study
Pulmonary veno-occlusive disease (pVOD) is a potentially life-threatening sequela of allogeneic haematopoietic stem-cell transplantation (alloHSCT). We conducted a morphometric evaluation of autopsy lung tissue to determine the incidence of pVOD and its association with donor type, conditioning regi...
Gespeichert in:
Veröffentlicht in: | Pathology, research and practice research and practice, 2022-03, Vol.231, p.153799-153799, Article 153799 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 153799 |
---|---|
container_issue | |
container_start_page | 153799 |
container_title | Pathology, research and practice |
container_volume | 231 |
creator | Kreft, Andreas Alverson, Christopher Wagner-Drouet, Eva-Maria Ries, Isabelle Sommer, Clemens Dr.re.nat, Mario Schindeldecker |
description | Pulmonary veno-occlusive disease (pVOD) is a potentially life-threatening sequela of allogeneic haematopoietic stem-cell transplantation (alloHSCT). We conducted a morphometric evaluation of autopsy lung tissue to determine the incidence of pVOD and its association with donor type, conditioning regime, hepatic sinusoidal obstruction syndrome (hSOS), survival time, and graft versus host disease (GvHD). The degree of occlusion of pulmonary veins in 78 autopsy cases after alloHSCT and 12 control cases was assigned to one of the following categories: none, minor thickening of the intima (up to 33% narrowing), moderate pVOD wherein about half of the lumen (34–66%) is occluded, or advanced pVOD with near total or total (67–100%) obliteration of the lumen. Minor thickening of the intima was found in all patients after alloHSCT (median: 66% of the vessels) and it was found to a lesser extent in the control cases (median: 12%). Moderate to advanced pVOD was seen in 95% of the cases, but only in a minority of the veins and venules (median: 6% of the veins and venules). PVOD was not significantly correlated with other histopathological findings within the lungs, including acute pneumonia, desquamative pneumonia, acute respiratory distress syndrome, organising and non-specific pneumonia, and bronchiolitis obliterans or acute lung disease. PVOD was significantly associated with a conditioning regimen including cyclophosphamide, fludarabine, or antithymocyte globulin and the duration of survival after alloHSCT. It was not associated with acute or chronic GvHD, other intestinal lung diseases, hSOS, or donor characteristics. PVOD was found in most patients after they underwent alloHSCT, although it mainly involved only a minority of the vessels. It was associated with the conditioning regime and the duration of survival after alloHSCT. |
doi_str_mv | 10.1016/j.prp.2022.153799 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2630922249</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0344033822000425</els_id><sourcerecordid>2630922249</sourcerecordid><originalsourceid>FETCH-LOGICAL-c305t-a6c0131afc231ec3a58cd51692d3557342519356179ffaf4b7690990a3bf04f53</originalsourceid><addsrcrecordid>eNp9kMFO3DAQhq2qVVloH6AX5COXLGM7dtbtCaEWkJB6aXu1vM4YvErsYDtI-_ZktcCxp9GMvvk18xHyjcGaAVOXu_WUpzUHztdMik7rD2TFFNs0oAT7SFYg2rYBITYn5LSUHQB00LLP5ERItgHV6hWJ_zCmJjk3zCU8I-1DQVuQJk_rI9Jhjg_U-oqZ2mFIDxgxOPpocbQ1TSlgXdpScWwcDgOt2cYyDTZWW0OK3-lVpHZeyLJfqLnffyGfvB0Kfn2tZ-Tvr59_rm-b-983d9dX940TIGtjlQMmmPWOC4ZOWLlxvWRK815I2YmWS6aFVKzT3lvfbjulQWuwYuuh9VKckYtj7pTT04ylmjGUw4k2YpqL4UqA5py3ekHZEXU5lZLRmymH0ea9YWAOms1umUzmoNkcNS8756_x83bE_n3jzesC_DgCuDz5HDCb4gJGh33I6KrpU_hP_AvhZ46a</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2630922249</pqid></control><display><type>article</type><title>Veno-occlusive disease of the lung after allogeneic haematopoietic stem-cell transplantation: An autopsy study</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Kreft, Andreas ; Alverson, Christopher ; Wagner-Drouet, Eva-Maria ; Ries, Isabelle ; Sommer, Clemens ; Dr.re.nat, Mario Schindeldecker</creator><creatorcontrib>Kreft, Andreas ; Alverson, Christopher ; Wagner-Drouet, Eva-Maria ; Ries, Isabelle ; Sommer, Clemens ; Dr.re.nat, Mario Schindeldecker</creatorcontrib><description>Pulmonary veno-occlusive disease (pVOD) is a potentially life-threatening sequela of allogeneic haematopoietic stem-cell transplantation (alloHSCT). We conducted a morphometric evaluation of autopsy lung tissue to determine the incidence of pVOD and its association with donor type, conditioning regime, hepatic sinusoidal obstruction syndrome (hSOS), survival time, and graft versus host disease (GvHD). The degree of occlusion of pulmonary veins in 78 autopsy cases after alloHSCT and 12 control cases was assigned to one of the following categories: none, minor thickening of the intima (up to 33% narrowing), moderate pVOD wherein about half of the lumen (34–66%) is occluded, or advanced pVOD with near total or total (67–100%) obliteration of the lumen. Minor thickening of the intima was found in all patients after alloHSCT (median: 66% of the vessels) and it was found to a lesser extent in the control cases (median: 12%). Moderate to advanced pVOD was seen in 95% of the cases, but only in a minority of the veins and venules (median: 6% of the veins and venules). PVOD was not significantly correlated with other histopathological findings within the lungs, including acute pneumonia, desquamative pneumonia, acute respiratory distress syndrome, organising and non-specific pneumonia, and bronchiolitis obliterans or acute lung disease. PVOD was significantly associated with a conditioning regimen including cyclophosphamide, fludarabine, or antithymocyte globulin and the duration of survival after alloHSCT. It was not associated with acute or chronic GvHD, other intestinal lung diseases, hSOS, or donor characteristics. PVOD was found in most patients after they underwent alloHSCT, although it mainly involved only a minority of the vessels. It was associated with the conditioning regime and the duration of survival after alloHSCT.</description><identifier>ISSN: 0344-0338</identifier><identifier>EISSN: 1618-0631</identifier><identifier>DOI: 10.1016/j.prp.2022.153799</identifier><identifier>PMID: 35180649</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Adult ; Aged ; Allogeneic haematopoietic stem-cell transplantation ; Autopsy ; Autopsy - methods ; Autopsy - statistics & numerical data ; Female ; Hematopoietic Stem Cell Transplantation - methods ; Hematopoietic Stem Cell Transplantation - statistics & numerical data ; Humans ; Lung - pathology ; Male ; Middle Aged ; Pulmonary vena occlusive disease ; Pulmonary Veno-Occlusive Disease - therapy ; Sinusoidal obstruction syndrome ; Transplantation, Homologous - methods ; Transplantation, Homologous - statistics & numerical data</subject><ispartof>Pathology, research and practice, 2022-03, Vol.231, p.153799-153799, Article 153799</ispartof><rights>2022 Elsevier GmbH</rights><rights>Copyright © 2022 Elsevier GmbH. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c305t-a6c0131afc231ec3a58cd51692d3557342519356179ffaf4b7690990a3bf04f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.prp.2022.153799$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35180649$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kreft, Andreas</creatorcontrib><creatorcontrib>Alverson, Christopher</creatorcontrib><creatorcontrib>Wagner-Drouet, Eva-Maria</creatorcontrib><creatorcontrib>Ries, Isabelle</creatorcontrib><creatorcontrib>Sommer, Clemens</creatorcontrib><creatorcontrib>Dr.re.nat, Mario Schindeldecker</creatorcontrib><title>Veno-occlusive disease of the lung after allogeneic haematopoietic stem-cell transplantation: An autopsy study</title><title>Pathology, research and practice</title><addtitle>Pathol Res Pract</addtitle><description>Pulmonary veno-occlusive disease (pVOD) is a potentially life-threatening sequela of allogeneic haematopoietic stem-cell transplantation (alloHSCT). We conducted a morphometric evaluation of autopsy lung tissue to determine the incidence of pVOD and its association with donor type, conditioning regime, hepatic sinusoidal obstruction syndrome (hSOS), survival time, and graft versus host disease (GvHD). The degree of occlusion of pulmonary veins in 78 autopsy cases after alloHSCT and 12 control cases was assigned to one of the following categories: none, minor thickening of the intima (up to 33% narrowing), moderate pVOD wherein about half of the lumen (34–66%) is occluded, or advanced pVOD with near total or total (67–100%) obliteration of the lumen. Minor thickening of the intima was found in all patients after alloHSCT (median: 66% of the vessels) and it was found to a lesser extent in the control cases (median: 12%). Moderate to advanced pVOD was seen in 95% of the cases, but only in a minority of the veins and venules (median: 6% of the veins and venules). PVOD was not significantly correlated with other histopathological findings within the lungs, including acute pneumonia, desquamative pneumonia, acute respiratory distress syndrome, organising and non-specific pneumonia, and bronchiolitis obliterans or acute lung disease. PVOD was significantly associated with a conditioning regimen including cyclophosphamide, fludarabine, or antithymocyte globulin and the duration of survival after alloHSCT. It was not associated with acute or chronic GvHD, other intestinal lung diseases, hSOS, or donor characteristics. PVOD was found in most patients after they underwent alloHSCT, although it mainly involved only a minority of the vessels. It was associated with the conditioning regime and the duration of survival after alloHSCT.</description><subject>Adult</subject><subject>Aged</subject><subject>Allogeneic haematopoietic stem-cell transplantation</subject><subject>Autopsy</subject><subject>Autopsy - methods</subject><subject>Autopsy - statistics & numerical data</subject><subject>Female</subject><subject>Hematopoietic Stem Cell Transplantation - methods</subject><subject>Hematopoietic Stem Cell Transplantation - statistics & numerical data</subject><subject>Humans</subject><subject>Lung - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pulmonary vena occlusive disease</subject><subject>Pulmonary Veno-Occlusive Disease - therapy</subject><subject>Sinusoidal obstruction syndrome</subject><subject>Transplantation, Homologous - methods</subject><subject>Transplantation, Homologous - statistics & numerical data</subject><issn>0344-0338</issn><issn>1618-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFO3DAQhq2qVVloH6AX5COXLGM7dtbtCaEWkJB6aXu1vM4YvErsYDtI-_ZktcCxp9GMvvk18xHyjcGaAVOXu_WUpzUHztdMik7rD2TFFNs0oAT7SFYg2rYBITYn5LSUHQB00LLP5ERItgHV6hWJ_zCmJjk3zCU8I-1DQVuQJk_rI9Jhjg_U-oqZ2mFIDxgxOPpocbQ1TSlgXdpScWwcDgOt2cYyDTZWW0OK3-lVpHZeyLJfqLnffyGfvB0Kfn2tZ-Tvr59_rm-b-983d9dX940TIGtjlQMmmPWOC4ZOWLlxvWRK815I2YmWS6aFVKzT3lvfbjulQWuwYuuh9VKckYtj7pTT04ylmjGUw4k2YpqL4UqA5py3ekHZEXU5lZLRmymH0ea9YWAOms1umUzmoNkcNS8756_x83bE_n3jzesC_DgCuDz5HDCb4gJGh33I6KrpU_hP_AvhZ46a</recordid><startdate>202203</startdate><enddate>202203</enddate><creator>Kreft, Andreas</creator><creator>Alverson, Christopher</creator><creator>Wagner-Drouet, Eva-Maria</creator><creator>Ries, Isabelle</creator><creator>Sommer, Clemens</creator><creator>Dr.re.nat, Mario Schindeldecker</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202203</creationdate><title>Veno-occlusive disease of the lung after allogeneic haematopoietic stem-cell transplantation: An autopsy study</title><author>Kreft, Andreas ; Alverson, Christopher ; Wagner-Drouet, Eva-Maria ; Ries, Isabelle ; Sommer, Clemens ; Dr.re.nat, Mario Schindeldecker</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-a6c0131afc231ec3a58cd51692d3557342519356179ffaf4b7690990a3bf04f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Allogeneic haematopoietic stem-cell transplantation</topic><topic>Autopsy</topic><topic>Autopsy - methods</topic><topic>Autopsy - statistics & numerical data</topic><topic>Female</topic><topic>Hematopoietic Stem Cell Transplantation - methods</topic><topic>Hematopoietic Stem Cell Transplantation - statistics & numerical data</topic><topic>Humans</topic><topic>Lung - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pulmonary vena occlusive disease</topic><topic>Pulmonary Veno-Occlusive Disease - therapy</topic><topic>Sinusoidal obstruction syndrome</topic><topic>Transplantation, Homologous - methods</topic><topic>Transplantation, Homologous - statistics & numerical data</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kreft, Andreas</creatorcontrib><creatorcontrib>Alverson, Christopher</creatorcontrib><creatorcontrib>Wagner-Drouet, Eva-Maria</creatorcontrib><creatorcontrib>Ries, Isabelle</creatorcontrib><creatorcontrib>Sommer, Clemens</creatorcontrib><creatorcontrib>Dr.re.nat, Mario Schindeldecker</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology, research and practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kreft, Andreas</au><au>Alverson, Christopher</au><au>Wagner-Drouet, Eva-Maria</au><au>Ries, Isabelle</au><au>Sommer, Clemens</au><au>Dr.re.nat, Mario Schindeldecker</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Veno-occlusive disease of the lung after allogeneic haematopoietic stem-cell transplantation: An autopsy study</atitle><jtitle>Pathology, research and practice</jtitle><addtitle>Pathol Res Pract</addtitle><date>2022-03</date><risdate>2022</risdate><volume>231</volume><spage>153799</spage><epage>153799</epage><pages>153799-153799</pages><artnum>153799</artnum><issn>0344-0338</issn><eissn>1618-0631</eissn><abstract>Pulmonary veno-occlusive disease (pVOD) is a potentially life-threatening sequela of allogeneic haematopoietic stem-cell transplantation (alloHSCT). We conducted a morphometric evaluation of autopsy lung tissue to determine the incidence of pVOD and its association with donor type, conditioning regime, hepatic sinusoidal obstruction syndrome (hSOS), survival time, and graft versus host disease (GvHD). The degree of occlusion of pulmonary veins in 78 autopsy cases after alloHSCT and 12 control cases was assigned to one of the following categories: none, minor thickening of the intima (up to 33% narrowing), moderate pVOD wherein about half of the lumen (34–66%) is occluded, or advanced pVOD with near total or total (67–100%) obliteration of the lumen. Minor thickening of the intima was found in all patients after alloHSCT (median: 66% of the vessels) and it was found to a lesser extent in the control cases (median: 12%). Moderate to advanced pVOD was seen in 95% of the cases, but only in a minority of the veins and venules (median: 6% of the veins and venules). PVOD was not significantly correlated with other histopathological findings within the lungs, including acute pneumonia, desquamative pneumonia, acute respiratory distress syndrome, organising and non-specific pneumonia, and bronchiolitis obliterans or acute lung disease. PVOD was significantly associated with a conditioning regimen including cyclophosphamide, fludarabine, or antithymocyte globulin and the duration of survival after alloHSCT. It was not associated with acute or chronic GvHD, other intestinal lung diseases, hSOS, or donor characteristics. PVOD was found in most patients after they underwent alloHSCT, although it mainly involved only a minority of the vessels. It was associated with the conditioning regime and the duration of survival after alloHSCT.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>35180649</pmid><doi>10.1016/j.prp.2022.153799</doi><tpages>1</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0344-0338 |
ispartof | Pathology, research and practice, 2022-03, Vol.231, p.153799-153799, Article 153799 |
issn | 0344-0338 1618-0631 |
language | eng |
recordid | cdi_proquest_miscellaneous_2630922249 |
source | MEDLINE; Elsevier ScienceDirect Journals Complete |
subjects | Adult Aged Allogeneic haematopoietic stem-cell transplantation Autopsy Autopsy - methods Autopsy - statistics & numerical data Female Hematopoietic Stem Cell Transplantation - methods Hematopoietic Stem Cell Transplantation - statistics & numerical data Humans Lung - pathology Male Middle Aged Pulmonary vena occlusive disease Pulmonary Veno-Occlusive Disease - therapy Sinusoidal obstruction syndrome Transplantation, Homologous - methods Transplantation, Homologous - statistics & numerical data |
title | Veno-occlusive disease of the lung after allogeneic haematopoietic stem-cell transplantation: An autopsy study |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T04%3A22%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Veno-occlusive%20disease%20of%20the%20lung%20after%20allogeneic%20haematopoietic%20stem-cell%20transplantation:%20An%20autopsy%20study&rft.jtitle=Pathology,%20research%20and%20practice&rft.au=Kreft,%20Andreas&rft.date=2022-03&rft.volume=231&rft.spage=153799&rft.epage=153799&rft.pages=153799-153799&rft.artnum=153799&rft.issn=0344-0338&rft.eissn=1618-0631&rft_id=info:doi/10.1016/j.prp.2022.153799&rft_dat=%3Cproquest_cross%3E2630922249%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2630922249&rft_id=info:pmid/35180649&rft_els_id=S0344033822000425&rfr_iscdi=true |