Rational Design for Nitroreductase (NTR)-Responsive Proteolysis Targeting Chimeras (PROTACs) Selectively Targeting Tumor Tissues

The catalytic properties of proteolysis targeting chimeras (PROTACs) may lead to uncontrolled off-tissue target degradation that causes potential toxicity, limiting their clinical applications. The precise control of this technology in a tissue-selective manner can minimize the potential toxicity. H...

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Veröffentlicht in:	Journal of medicinal chemistry 2022-03, Vol.65 (6), p.5057-5071
Hauptverfasser:	Shi, Shi, Du, Yu, Zou, Yi, Niu, Jing, Cai, Zeyu, Wang, Xiaonan, Qiu, Feihuang, Ding, Yi, Yang, Gengchen, Wu, Yunze, Xu, Yungen, Zhu, Qihua
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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