Body weight regulation via MT1-MMP-mediated cleavage of GFRAL

GDNF-family receptor a-like (GFRAL) has been identified as the cognate receptor of growth/differentiation factor 15 (GDF15/MIC-1), considered a key signaling axis in energy homeostasis and body weight regulation. Currently, little is known about the physiological regulation of the GDF15–GFRAL signal...

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Veröffentlicht in:	Nature metabolism 2022-02, Vol.4 (2), p.203-212
Hauptverfasser:	Chow, Chi Fung Willis, Guo, Xuanming, Asthana, Pallavi, Zhang, Shuo, Wong, Sheung Kin Ken, Fallah, Samane, Che, Sijia, Gurung, Susma, Wang, Zening, Lee, Ki Baek, Ge, Xin, Yuan, Shiyang, Xu, Haoyu, Ip, Jacque Pak Kan, Jiang, Zhixin, Zhai, Lixiang, Wu, Jiayan, Zhang, Yijing, Mahato, Arun Kumar, Saarma, Mart, Lin, Cheng Yuan, Kwan, Hiu Yee, Huang, Tao, Lyu, Aiping, Zhou, Zhongjun, Bian, Zhao-Xiang, Wong, Hoi Leong Xavier
Format:	Artikel
Sprache:	eng
Schlagworte:	13/95 14/19 631/443/319/1642/393 631/45/468 631/80/86/820 64/110 82/80 96/106 96/109 96/63 96/95 Animals Anorexia - metabolism Biomedical and Life Sciences Body Weight Glial Cell Line-Derived Neurotrophic Factor Receptors - genetics Glial Cell Line-Derived Neurotrophic Factor Receptors - metabolism Life Sciences Matrix Metalloproteinase 14 - therapeutic use Mice Obesity - metabolism
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