The Discovery of Chicken Foxp3 Demands Redefinition of Avian Regulatory T Cells

Since the publication of the first chicken genome sequence, we have encountered genes playing key roles in mammalian immunology, but being seemingly absent in birds. One of those was, until recently, Foxp3, the master transcription factor of regulatory T cells in mammals. Therefore, avian regulatory...

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Veröffentlicht in:	The Journal of immunology (1950) 2022-03, Vol.208 (5), p.1128-1138
Hauptverfasser:	Burkhardt, Nina B, Elleder, Daniel, Schusser, Benjamin, Krchlíková, Veronika, Göbel, Thomas W, Härtle, Sonja, Kaspers, Bernd
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence - genetics Animals Base Sequence Cell Differentiation - immunology Chickens - genetics Chickens - immunology Forkhead Transcription Factors - genetics Gene Expression Profiling Genome - genetics Interleukin-2 Receptor alpha Subunit - metabolism Lymphocyte Activation - immunology Sequence Alignment Sequence Analysis, DNA Sequence Homology T-Lymphocytes, Regulatory - immunology
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