Association of the Cerebro‐Placental Ratio With Adverse Outcomes in Pregnancies Affected by Gestational Diabetes Mellitus

Objectives Cerebro‐placental ratio (CPR) is a doppler tool contributes to clinical decision‐making in pregnancies affected by small for gestational age weight (SGA). Pregnancies affected by gestational diabetes mellitus (GDM) tend to have higher newborn weight, but greater risk of adverse perinatal outcomes. We hypothesized that in GDM‐complicated‐pregnancies CPR will be associated with adverse perinatal outcomes even in the absence of SGA. Methods This prospective single‐center cohort study included non‐anomalous singleton pregnancies in women with GDM. Those with pre‐pregnancy diabetes mellitus, hypertensive disorder or suspected SGA were excluded. Routine fetal sonographic assessment included CPR—defined as middle cerebral artery pulsatilty index/umbilical artery pulsatilty index. Masked CPR measurement closest to birth was used, classified as >10th (normal) or ≤10th centile (low). Primary outcome was a composite, consisting of stillbirth, Caesarean birth due to abnormal fetal heart rate pattern, 5‐minute Apgar