Maltol mitigates cisplatin‐evoked cardiotoxicity via inhibiting the PI3K/Akt signaling pathway in rodents in vivo and in vitro

Our current research aims to evaluate the efficiency of a flavor enhancer, maltol (produced by heating ginseng) against cisplatin‐evoked cardiotoxicity by establishing cisplatin‐induced heart injury in vivo and H9C2 rat cardiomyocyte model. The cisplatin‐treated mice at 3 mg/kg for four times on the...

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Veröffentlicht in:	Phytotherapy research 2022-04, Vol.36 (4), p.1724-1735
Hauptverfasser:	Xing, Jing‐Jing, Mi, Xiao‐Jie, Hou, Jin‐Gang, Cai, En‐Bo, Zheng, Si‐Wen, Wang, Shi‐Han, Wang, Zi, Chen, Chen, Li, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Apoptosis Cardiomyocytes Cardiotoxicity Cardiotoxicity - drug therapy Caspase-3 Chemotherapy Cisplatin Cisplatin - adverse effects Damage H9C2 Heart maltol Mice Myocytes, Cardiac Oxidative stress Phosphatidylinositol 3-Kinases - metabolism PI3K/Akt Proto-Oncogene Proteins c-akt - metabolism Pyrones Rats Reactive oxygen species Rodentia - metabolism Signal Transduction Signaling
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