A Nanoarchitectonic Approach Enables Triple Modal Synergistic Therapies To Enhance Antitumor Effects
Improvement of antitumor effects relies on the development of biocompatible nanomaterials and combination of various therapies to produce synergistic effects and avoid resistance. In this work, we developed GBD-Fe, a nanoformulation that effectively integrated chemotherapy (CT), chemodynamic therapy...
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| Veröffentlicht in: | ACS applied materials & interfaces 2022-03, Vol.14 (8), p.10001-10014 |
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| container_title | ACS applied materials & interfaces |
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| creator | Mo, Zhimin Li, Qiuting Zhao, Kan Xu, Qi Hu, Han Chen, Xu Luo, Yuxuan Chi, Bin Liu, Liping Fang, Xiefan Liao, Guangfu Xu, Zushun Wang, Jing Yang, Shengli |
| description | Improvement of antitumor effects relies on the development of biocompatible nanomaterials and combination of various therapies to produce synergistic effects and avoid resistance. In this work, we developed GBD-Fe, a nanoformulation that effectively integrated chemotherapy (CT), chemodynamic therapy (CDT), and photothermal therapy (PTT). GBD-Fe used gold nanorods as photothermal agents and encapsulated doxorubicin to amplify Fe
-guided CDT effects by producing H
O
and reducing the intracellular glutathione levels. In vitro and in vivo experiments were conducted to demonstrate the enhanced accumulation and antitumor effects of this tripronged therapy under magnetic resonance imaging (MRI) guidance. This tripronged approach of CT/CDT/PTT effectively induced tumor cytotoxicity and inhibited tumor growth in tumor-bearing mice and therefore represents a promising strategy to effectively treat tumors. |
| doi_str_mv | 10.1021/acsami.1c20416 |
| format | Article |
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-guided CDT effects by producing H
O
and reducing the intracellular glutathione levels. In vitro and in vivo experiments were conducted to demonstrate the enhanced accumulation and antitumor effects of this tripronged therapy under magnetic resonance imaging (MRI) guidance. This tripronged approach of CT/CDT/PTT effectively induced tumor cytotoxicity and inhibited tumor growth in tumor-bearing mice and therefore represents a promising strategy to effectively treat tumors.</description><identifier>ISSN: 1944-8244</identifier><identifier>EISSN: 1944-8252</identifier><identifier>DOI: 10.1021/acsami.1c20416</identifier><identifier>PMID: 35172581</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Cell Line, Tumor ; Doxorubicin - pharmacology ; Doxorubicin - therapeutic use ; Gold ; Hydrogen Peroxide ; Mice ; Nanotubes ; Neoplasms - drug therapy</subject><ispartof>ACS applied materials & interfaces, 2022-03, Vol.14 (8), p.10001-10014</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c295t-1021939dd3917d936c207d998773c5fa64413e2723016f4c28ce76b7ded00943</citedby><cites>FETCH-LOGICAL-c295t-1021939dd3917d936c207d998773c5fa64413e2723016f4c28ce76b7ded00943</cites><orcidid>0000-0003-1299-8106 ; 0000-0001-7314-170X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2752,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35172581$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mo, Zhimin</creatorcontrib><creatorcontrib>Li, Qiuting</creatorcontrib><creatorcontrib>Zhao, Kan</creatorcontrib><creatorcontrib>Xu, Qi</creatorcontrib><creatorcontrib>Hu, Han</creatorcontrib><creatorcontrib>Chen, Xu</creatorcontrib><creatorcontrib>Luo, Yuxuan</creatorcontrib><creatorcontrib>Chi, Bin</creatorcontrib><creatorcontrib>Liu, Liping</creatorcontrib><creatorcontrib>Fang, Xiefan</creatorcontrib><creatorcontrib>Liao, Guangfu</creatorcontrib><creatorcontrib>Xu, Zushun</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Yang, Shengli</creatorcontrib><title>A Nanoarchitectonic Approach Enables Triple Modal Synergistic Therapies To Enhance Antitumor Effects</title><title>ACS applied materials & interfaces</title><addtitle>ACS Appl Mater Interfaces</addtitle><description>Improvement of antitumor effects relies on the development of biocompatible nanomaterials and combination of various therapies to produce synergistic effects and avoid resistance. In this work, we developed GBD-Fe, a nanoformulation that effectively integrated chemotherapy (CT), chemodynamic therapy (CDT), and photothermal therapy (PTT). GBD-Fe used gold nanorods as photothermal agents and encapsulated doxorubicin to amplify Fe
-guided CDT effects by producing H
O
and reducing the intracellular glutathione levels. In vitro and in vivo experiments were conducted to demonstrate the enhanced accumulation and antitumor effects of this tripronged therapy under magnetic resonance imaging (MRI) guidance. This tripronged approach of CT/CDT/PTT effectively induced tumor cytotoxicity and inhibited tumor growth in tumor-bearing mice and therefore represents a promising strategy to effectively treat tumors.</description><subject>Animals</subject><subject>Cell Line, Tumor</subject><subject>Doxorubicin - pharmacology</subject><subject>Doxorubicin - therapeutic use</subject><subject>Gold</subject><subject>Hydrogen Peroxide</subject><subject>Mice</subject><subject>Nanotubes</subject><subject>Neoplasms - drug therapy</subject><issn>1944-8244</issn><issn>1944-8252</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kD1PwzAYhC0EoqWwMiKPLCn-ihOPUVU-pAID2SPXdohREgc7GfrvcZXS6d7hudO9B8A9RmuMCH6SKsjOrrEiiGF-AZZYMJbkJCWX55uxBbgJ4QchTglKr8GCpjgjaY6XQBfwQ_ZOetXY0ajR9VbBYhi8k6qB217uWxNg6e3QGvjutGzh16E3_tuGMZJlY7wc7BFxkW5krwws-tGOU-c83NZ1zAy34KqWbTB3J12B8nlbbl6T3efL26bYJYqIdEyODwkqtKYCZ1pQHp-KKvIsoyqtJWcMU0MyQhHmNVMkVybj-0wbjZBgdAUe59jY_ncyYaw6G5RpW9kbN4WKcCJyjqI_ousZVd6F4E1dDd520h8qjKpjj2oetjoNGw0Pp-xp3xl9xv-XpH-2AXSc</recordid><startdate>20220302</startdate><enddate>20220302</enddate><creator>Mo, Zhimin</creator><creator>Li, Qiuting</creator><creator>Zhao, Kan</creator><creator>Xu, Qi</creator><creator>Hu, Han</creator><creator>Chen, Xu</creator><creator>Luo, Yuxuan</creator><creator>Chi, Bin</creator><creator>Liu, Liping</creator><creator>Fang, Xiefan</creator><creator>Liao, Guangfu</creator><creator>Xu, Zushun</creator><creator>Wang, Jing</creator><creator>Yang, Shengli</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1299-8106</orcidid><orcidid>https://orcid.org/0000-0001-7314-170X</orcidid></search><sort><creationdate>20220302</creationdate><title>A Nanoarchitectonic Approach Enables Triple Modal Synergistic Therapies To Enhance Antitumor Effects</title><author>Mo, Zhimin ; Li, Qiuting ; Zhao, Kan ; Xu, Qi ; Hu, Han ; Chen, Xu ; Luo, Yuxuan ; Chi, Bin ; Liu, Liping ; Fang, Xiefan ; Liao, Guangfu ; Xu, Zushun ; Wang, Jing ; Yang, Shengli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c295t-1021939dd3917d936c207d998773c5fa64413e2723016f4c28ce76b7ded00943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Cell Line, Tumor</topic><topic>Doxorubicin - pharmacology</topic><topic>Doxorubicin - therapeutic use</topic><topic>Gold</topic><topic>Hydrogen Peroxide</topic><topic>Mice</topic><topic>Nanotubes</topic><topic>Neoplasms - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mo, Zhimin</creatorcontrib><creatorcontrib>Li, Qiuting</creatorcontrib><creatorcontrib>Zhao, Kan</creatorcontrib><creatorcontrib>Xu, Qi</creatorcontrib><creatorcontrib>Hu, Han</creatorcontrib><creatorcontrib>Chen, Xu</creatorcontrib><creatorcontrib>Luo, Yuxuan</creatorcontrib><creatorcontrib>Chi, Bin</creatorcontrib><creatorcontrib>Liu, Liping</creatorcontrib><creatorcontrib>Fang, Xiefan</creatorcontrib><creatorcontrib>Liao, Guangfu</creatorcontrib><creatorcontrib>Xu, Zushun</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Yang, Shengli</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ACS applied materials & interfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mo, Zhimin</au><au>Li, Qiuting</au><au>Zhao, Kan</au><au>Xu, Qi</au><au>Hu, Han</au><au>Chen, Xu</au><au>Luo, Yuxuan</au><au>Chi, Bin</au><au>Liu, Liping</au><au>Fang, Xiefan</au><au>Liao, Guangfu</au><au>Xu, Zushun</au><au>Wang, Jing</au><au>Yang, Shengli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Nanoarchitectonic Approach Enables Triple Modal Synergistic Therapies To Enhance Antitumor Effects</atitle><jtitle>ACS applied materials & interfaces</jtitle><addtitle>ACS Appl Mater Interfaces</addtitle><date>2022-03-02</date><risdate>2022</risdate><volume>14</volume><issue>8</issue><spage>10001</spage><epage>10014</epage><pages>10001-10014</pages><issn>1944-8244</issn><eissn>1944-8252</eissn><abstract>Improvement of antitumor effects relies on the development of biocompatible nanomaterials and combination of various therapies to produce synergistic effects and avoid resistance. 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-guided CDT effects by producing H
O
and reducing the intracellular glutathione levels. In vitro and in vivo experiments were conducted to demonstrate the enhanced accumulation and antitumor effects of this tripronged therapy under magnetic resonance imaging (MRI) guidance. This tripronged approach of CT/CDT/PTT effectively induced tumor cytotoxicity and inhibited tumor growth in tumor-bearing mice and therefore represents a promising strategy to effectively treat tumors.</abstract><cop>United States</cop><pmid>35172581</pmid><doi>10.1021/acsami.1c20416</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-1299-8106</orcidid><orcidid>https://orcid.org/0000-0001-7314-170X</orcidid></addata></record> |
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| subjects | Animals Cell Line, Tumor Doxorubicin - pharmacology Doxorubicin - therapeutic use Gold Hydrogen Peroxide Mice Nanotubes Neoplasms - drug therapy |
| title | A Nanoarchitectonic Approach Enables Triple Modal Synergistic Therapies To Enhance Antitumor Effects |
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